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Protein Overview: CNS1

General Information:
Name(s) found: CNS1 / YBR155W [SGD]
Description(s) found:
Found 28 descriptions.
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  • TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 385 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IPILink to PubMed article]
    Biological Process: protein folding [IGILink to PubMed article][IPILink to PubMed article]
    Molecular Function: Hsp90 protein binding [IDALink to PubMed article]
    Hsp70 protein binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSVNANGGY TKPQKYVPGP GDPELPPQLS EFKDKTSDEI LKEMNRMPFF MTKLDETDGA  60
   61 GGENVELEAL KALAYEGEPH EIAENFKKQG NELYKAKRFK DARELYSKGL AVECEDKSIN 120
  121 ESLYANRAAC ELELKNYRRC IEDCSKALTI NPKNVKCYYR TSKAFFQLNK LEEAKSAATF 180
  181 ANQRIDPENK SILNMLSVID RKEQELKAKE EKQQREAQER ENKKIMLESA MTLRNITNIK 240
  241 THSPVELLNE GKIRLEDPMD FESQLIYPAL IMYPTQDEFD FVGEVSELTT VQELVDLVLE 300
  301 GPQERFKKEG KENFTPKKVL VFMETKAGGL IKAGKKLTFH DILKKESPDV PLFDNALKIY 360
  361 IVPKVESEGW ISKWDKQKAL ERRSV

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) AHA1 BUD3 CNS1 CPR6 DIG2 DNM1 DSF1, YNR073C FRT2 GPA2 HOM6 HSC82 HSP104 HSP82 MBB1 MRPL50 PAM1 PPT1 QNS1 RMD8 RTS1 SMT3 STI1 STP4 TDH1 UTP20 YBL104C
    View Details Gavin AC, et al. (2002) CNS1 HGH1
    View Details Ho Y, et al. (2002) CNS1 ECM10 ILV5 YHB1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen CNS1 STP1 2 Uetz P, et al. (2000)

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data CNS1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..134] PSI-BLAST 103.211549 Cyclophilin 40; Cyclophilin 40 isomerase domain
    2 View Details [135..287] PSI-BLAST 103.211549 Cyclophilin 40; Cyclophilin 40 isomerase domain
    3 View Details [288..385] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  2.12690485191789 bayes_pls_golite062009
  • protein binding
    		•  1.37554190575452 bayes_pls_golite062009
  • heat shock protein binding
    		•  1.35268080101836 bayes_pls_golite062009
  • unfolded protein binding
    		•  1.03065657981002 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.41706917101675 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.194719472400022 bayes_pls_golite062009
  • DNA binding
    		•  0.17736976899009 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle