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Protein Overview: NOP1

General Information:
Name(s) found: NOP1 / YDL014W [SGD]
Description(s) found:
Found 28 descriptions.
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  • Nucleolar protein, component of the small subunit processome complex, which is required for processing of pre-18S rRNA; has similarity to mammalian fibrillarin [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 327 amino acids

    Gene Ontology:
    Cellular Component: nuclear outer membrane [TASLink to PubMed article]
    nucleolus [IDALink to PubMed article]
    ribosome [IDALink to PubMed article]
    small nucleolar ribonucleoprotein complex [IPILink to PubMed article]
    Biological Process: rRNA modification [TASLink to PubMed article]
    RNA methylation [IMPLink to PubMed article][IPILink to PubMed article][ISSLink to PubMed article]
    maturation of SSU-rRNA [IPILink to PubMed article]
    ribosome biogenesis [RCALink to PubMed article]
    ribosomal large subunit assembly [TASLink to PubMed article]
    snoRNA 3'-end processing [IMPLink to PubMed article]
    Molecular Function: methyltransferase activity [IMPLink to PubMed article][IPILink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFRPGSRGG SRGGSRGGFG GRGGSRGGAR GGSRGGFGGR GGSRGGARGG SRGGFGGRGG  60
   61 SRGGARGGSR GGRGGAAGGA RGGAKVVIEP HRHAGVYIAR GKEDLLVTKN MAPGESVYGE 120
  121 KRISVEEPSK EDGVPPTKVE YRVWNPFRSK LAAGIMGGLD ELFIAPGKKV LYLGAASGTS 180
  181 VSHVSDVVGP EGVVYAVEFS HRPGRELISM AKKRPNIIPI IEDARHPQKY RMLIGMVDCV 240
  241 FADVAQPDQA RIIALNSHMF LKDQGGVVIS IKANCIDSTV DAETVFAREV QKLREERIKP 300
  301 LEQLTLEPYE RDHCIVVGRY MRSGLKK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) BFR2 BMS1 CBF5 DIP2 ECM16 EMG1 ENP1 ENP2 ERB1 HAS1 IMP3 IMP4 KRE33 KRR1 MPP10 NAN1 NIP7 NOC2 NOC4 NOP1 NOP12 NOP14 NOP56 NOP7 PNO1 PRP43 PUF6 PWP2 RPS13 RPS7A RRP12 RRP9 SOF1 SRO9 UTP10 UTP13 UTP15 UTP20 UTP21 UTP22 UTP30 UTP4 UTP6 UTP7 UTP8 YTM1
    View Details (MIPS) Mewes HW, et al. (2004) DRS1 GAR1 IFH1 NOP1 NOP56 NOP58 NPL3 NSR1 POP1 POP2 RAT1 RNT1 RRP3 SBP1 SNM1 SRD1 UTP10 UTP11 UTP13 UTP4 UTP5 UTP6 UTP7 UTP8 UTP9 YME2
    View Details Krogan NJ, et al. (2006) BUD22 CIC1 DBP6 EFG1 FRE3 GIS2 HAS1 MAK21 NIP7 NOB1 NOC2 NOC3 NOP1 NOP2 NOP8 PUS7 RRP5 RSA3 SBP1 SFA1 SSQ1 YGR272C YMR034C YRF1-8, YRF1-5, ...
    View Details Gavin AC, et al. (2002) AAR2 ADA2 ADE4 ADH1 ARX1 ASC1 AVO1 BEM2 BFR2 BMS1 BRX1 BUD20 BUD21 CBF5 CDC33 CEG1 CET1 CFT2 CIC1 CKA1 CKA2 CKB1 CKB2 CLF1 CLU1 CMS1 CTR9 CWC23 CYR1 CYS4 DBP10 DBP8 DBP9 DCP2 DHH1 DIA4 DIB1 DIM1 DIP2 DIS3 DRS1 EBP2 ECM16 ECM29 EMG1 ENP1 ENP2 ERB1 ERO1 ESF1 ESF2 FAP7 FIP1 FPR4 FUN12 FUN19 GAR1 GCN1 GCN5 GLC7 HAS1 HCA4 HDA1 HEM13 HER1 HHF1, HHF2 HIS3 HRR25 HSL1 HTA2 IMP3 IMP4 INP2 IPI1 IPI3 KAP114 KAP123 KRE33 KRR1 KRS1 LCP5 LHP1 LOC1 LSG1 LSM1 LSM12 LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 LTV1 MAK21 MAK5 MDN1 MED4 MES1 MIS1 MNN4 MOT1 MPP10 MRD1 MRP7 MRT4 MVD1 MYO1 NAM7 NAN1 NAP1 NGG1 NHP2 NIP1 NIP7 NMD3 NOB1 NOC2 NOC3 NOC4 NOG1 NOG2 NOP1 NOP12 NOP14 NOP15 NOP16 NOP2 NOP4 NOP56 NOP58 NOP6 NOP7 NSA1 NSA2 NUG1 PAP1 PAT1 PDB1 PFK2 PFS2 PNO1 POL2 PRE6 PRE9 PRP24 PRP31 PRP38 PRP4 PRP43 PRP46 PRP6 PRT1 PSK1 PTA1 PTC1 PTI1 PUF6 PWP2 RCL1 REF2 REI1 RIO2 RIX1 RIX7 RLP24 RLP7 RML2 RNA14 ROK1 RPA135 RPA190 RPB2 RPF1 RPF2 RPG1 RPN9 RPO21 RPP2B RPT5 RPT6 RRP1 RRP12 RRP7 RRP9 RSA3 RSA4 RTG2 RTR1 RVB2 SAM1 SCL1 SDA1 SEC21 SEC7 SGF29 SGF73 SIN3 SIN4 SKI2 SLX9 SMB1 SMD2 SNF2 SNF5 SNU114 SNU13 SNU23 SNU66 SOF1 SPB1 SPB4 SPP382 SPT15 SPT16 SPT20 SPT7 SPT8 SQS1 SRO9 SSA3 SSA4 SSF1 SWI3 TAF1 TAF10 TAF11 TAF12 TAF13 TAF14 TAF2 TAF3 TAF4 TAF5 TAF6 TAF7 TAF8 TAF9 TBF1 TEF4 TIF1, TIF2 TIF4631 TIF4632 TIF6 TOP2 TSR1 TUB3 URB1 UTP10 UTP11 UTP13 UTP15 UTP18 UTP20 UTP21 UTP22 UTP30 UTP4 UTP6 UTP7 UTP8 UTP9 VAS1 VPS1 YGL036W YGR054W YGR102C YMR310C YOR059C YSH1 YTM1
    View Details Ho Y, et al. (2002) BRX1 CDC28 CEG1 CIC1 CKA1 CKA2 CKB1 CKB2 COX6 DBP10 DHR2 DIP2 EBP2 ELA1 ESL2 FET4 FKH1 FYV8 GAR1 GCD2 GCD7 GCN3 HAS1 HHF1, HHF2 HTB1 IMD2 IMD3 IMD4 KRE33 LCP5 MAM33 MBP1 MGM101 MPH1 MSS116 NAN1 NET1 NIP7 NMD3 NOC2 NOG1 NOP1 NOP12 NOP2 NOP56 NOP7 NSA1 NSA2 NUG1 PET127 PHO84 PNO1 PRP40 PTC5 PUF6 PWP1 PWP2 RPF2 RRP1 RRP12 RRP15 RRP5 SAH1 SEC2 SEC27 SIN3 SPB1 SPT2 SRP1 SUI2 SUI3 TFP1 TIF6 TIS11 TPT1 UBP12 URE2 UTP10 UTP11 UTP13 UTP14 UTP18 UTP21 UTP22 UTP30 UTP6 YER077C YGR017W YMR144W YPL009C YTM1
    View Details Qiu et al. (2008) AIR1 DBP7 DHR2 DIM1 DRS1 GAR1 MAK5 NOP1 NOP2 NOP56 NPL3 POP1 RNT1 RRP9 SWD2 UTP13 UTP15 UTP4 UTP5 UTP7 UTP8

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run RLF2 cac1: TAP-tagged Green EM, et al (2005)
    View Run VAM3 Sample: HX12 - trans-SNARE complex formation and fusion are inhibited (control). Hao Xu, et al. (2010)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2 Keck JM, et al. (2011)
    View Run MLP2 #21 Asynchronous Prep2-IMAC Phosphopeptide enrichment A1 Keck JM, et al. (2011)
    View Run MLP2 #34 Asynchronous SPB prep Keck JM, et al. (2011)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #02 Alpha Factor Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)
    View Run MLP2 #06 Alpha Factor Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #08 Alpha Factor Prep4-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..83] ORFEUS 7.97 No description for 1la5A was found.
    2 View Details [84..327] PSI-BLAST 491.29073 Fibrillarin homologue


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle