YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: DPB4

General Information:
Name(s) found: DPB4 / YDR121W [SGD]
Description(s) found:
Found 27 descriptions.
SHOW ALL
  • Shared subunit of DNA polymerase (II) epsilon and of ISW2/yCHRAC chromatin accessibility complex; involved in both chromosomal DNA replication and in inheritance of telomeric silencing [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 196 amino acids

    Gene Ontology:
    Cellular Component: chromatin accessibility complex [IPILink to PubMed article]
    epsilon DNA polymerase complex [IDALink to PubMed article]
    Biological Process: lagging strand elongation [IGILink to PubMed article][IMPLink to PubMed article][IPILink to PubMed article]
    leading strand elongation [IGILink to PubMed article][IMPLink to PubMed article][IPILink to PubMed article]
    chromatin silencing at telomere [IMPLink to PubMed article]
    Molecular Function: DNA binding [IEA]
    nucleotidyltransferase activity [IEA]
    DNA-directed DNA polymerase activity [IEA][IMP][IPI]
    double-stranded DNA binding [IDA]
    transferase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPPKGWRKDA QGNYPTTSYI KEQENITIQD LLFPKSTIVN LAREVPQQSG KKLLINKDAS  60
   61 LALQRGATVF VNHLLLFARE IAKSQDKKSC SVDDVLSALD HIGHSALKGP VRDKLDEYQA 120
  121 AVEQRKKEKL DSGEVDADGD IDMGEDKENV PVEKVKEHDE IEEQGDALQD VEESSEKKQK 180
  181 TESQDVETRV QNLEQT

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) DPB2 DPB3 DPB4 ISW2 POL2
    View Details Krogan NJ, et al. (2006) DPB2 DPB3 DPB4 INM1 MBA1 MCM2 POL2 RPN4
    View Details Gavin AC, et al. (2006) DPB2 DPB4 POL2
    View Details Gavin AC, et al. (2002) DPB2 DPB4 ISW1 ISW2 KAP114 MOT1 NAP1 NPL6 POL2 PUF6 RET1 RPA135 RPC82 RPO31 STH1 TOP1 VPS1
    View Details Qiu et al. (2008) DLS1 DPB11 DPB2 DPB3 DPB4 MCM2 MCM3 MCM4 MCM5 MCM6 POL1 POL12 POL2 POL3 POL30 POL31 POL32 PRI1 PRI2 RFC1 RFC4

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run TID3 No Comments Cheeseman IM, et al. (2002)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data DPB4 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..34]
    [61..127]    		 PSI-BLAST 28.0 Negative cofactor 2, NC2, beta chain
    2 View Details [35..60]
    [128..196]    		 PSI-BLAST 28.0 Negative cofactor 2, NC2, beta chain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • DNA-directed DNA polymerase activity
    		•  7.30463919195401 bayes_pls_golite062009
  • DNA polymerase activity
    		•  7.25909396656216 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  4.91761894051618 bayes_pls_golite062009
  • DNA binding
    		•  4.49118409263799 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.35201412176948 bayes_pls_golite062009
  • transcription regulator activity
    		•  4.08606081850613 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  4.04353148658823 bayes_pls_golite062009
  • binding
    		•  3.27510691458843 bayes_pls_golite062009
  • transcription factor activity
    		•  2.51581622888695 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.38228606466152 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.3574713307436 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.71244156762178 bayes_pls_golite062009
  • transferase activity
    		•  1.4922191078713 bayes_pls_golite062009
  • transcription corepressor activity
    		•  1.30859203490073 bayes_pls_golite062009
  • transcription activator activity
    		•  1.25487495162413 bayes_pls_golite062009
  • transcription factor binding
    		•  1.15204005455906 bayes_pls_golite062009
  • transcription coactivator activity
    		•  1.1297723528047 bayes_pls_golite062009
  • protein binding
    		•  1.07873333188144 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.01502031330902 bayes_pls_golite062009
  • centromeric DNA binding
    		•  0.6937627559147 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.0852726470007639 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle