YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: EAF1

General Information:
Name(s) found: EAF1 / YDR359C [SGD]
Description(s) found:
Found 24 descriptions.
SHOW ALL
  • Component of the NuA4 histone acetyltransferase complex; acts as a platform for assembly of NuA4 subunits into the native complex; required for initiation of pre-meiotic DNA replication, likely due to its requirement for expression of IME1 [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 982 amino acids

    Gene Ontology:
    Cellular Component: NuA4 histone acetyltransferase complex [IPILink to PubMed articleLink to PubMed article]
    histone acetyltransferase complex [IPILink to PubMed article]
    Biological Process: chromatin modification [IPILink to PubMed article]
    DNA repair [IDALink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSRPSSAVP NSASLSEDQS SDRSKFPKAD DLIDERDRKL TELYCVSRLN QLLELTDENK  60
   61 LRKEIDAFLK KNDIRRGIRF DEASLPKLLH TAATPITKKK LKDVNLINVP NQRLSDSKMS 120
  121 RELPENSENV SVKSESHFVP SHDNSIRENM MDSLRPAEKT GGMWNKRPLE STMGGEEERH 180
  181 EKRQKMQSQS LESSNNSEMA SLPISPRPPV PNALAHYTYY ENIEYPPADP TEVQPAVKFK 240
  241 DPLIKNIMAK EIDTSDHYNE NNVDALETVF LLMNDYIPSK IPQALPLAEL KYMSQTLPLI 300
  301 NLIPRAHKAL TTNIINNALN EARITVVGSR IEELRRLGLW SLRQPKRFID PWKQHNTHQN 360
  361 ILLEEAKWMQ ADFKEGHKYK VAICTAMAQA IKDYWTYGEI CCVKRKTLLP GKENKLSDDG 420
  421 RISEKSGRPS DTSRNDSDIS IAGKDDIGII ANVDDITEKE SAAANDNDEN GKNEAGAKSD 480
  481 FDFADGLLSQ EGAHDQIISS IDTKLLLKKP SSSSEVVLIQ HEVAASSALI ETEESKKELA 540
  541 PPFKLSIFVD ELNTFEKTLI QDLPLYNGIN EERPKKDDSL PFIPISKSVV SLDDNGFYKL 600
  601 LERQLIDEEP SISQLSKRRG MFYGNRRNHY LRPPAVPSLR YLQNRTPTIW LSEDDQELVK 660
  661 NINTYGYNWE LISAHMTHRL TYSYLSNIER RTPWQCFERF VQLNERFNFS DLKGPRAHSA 720
  721 QQWLIEAHKF QQRQNRRISP LGVNTESIQR GHRRLRWASM FEAIRKCMKK RENTPRPNPT 780
  781 QPRKPLDCKN MKVPTPAEMS LLKAQRDEAL RRDIQLRRTV KNRLQQRQQQ SQQAHSSRAQ 840
  841 SPIPSNGKSS SNLARNGQAS APRPNQKQYT EQDIIESYSR KLLEQKPDIG PEMALKAAKN 900
  901 YYRTLREQQQ QLKQHQIQQQ RQQLQEESSH VQQLQQLQPG SQAPPPKSSP SQSSLSNISN 960
  961 INSAPRIKSP TPQEILQRFQ KQ

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ARP4 EAF1 EAF3 EAF5 EAF6 EAF7 EPL1 ESA1 SWC4 TRA1 YAF9 YNG2
    View Details Hazbun TR, et al. (2003) ARP4 EAF1 EAF5 EPL1 ESA1 RVB1 RVB2 SWC4 SWR1 TRA1 YAF9 YNG2
    View Details Krogan NJ, et al. (2006) ARP4 ARP5 ARP6 ARP8 CCA1 EAF1 EAF5 EAF6 EAF7 EPL1 ESA1 IES1 IES2 IES3 IES4 IES5 IES6 INO80 NHP10 NTO1 PIH1 RVB1 RVB2 SAS3 SWC3 SWC4 SWC5 SWC7 SWR1 TAH1 TRA1 VPS71 VPS72 YAF9 YNG2
    View Details Gavin AC, et al. (2002) ACT1 ADH1 ARP4 EAF1 EAF3 EAF5 EPL1 ESA1 HHF1, HHF2 TRA1 YAF9 YAP1
    View Details Ho Y, et al. (2002) ARP4 ATE1 CDC33 CKA2 EAF1 EPL1 ESA1 HOG1 HRR25 POR1 RCK2 SAP185 SIT4 TAF14 TAF4 TIP41 TRA1 TUF1 YRA1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen SWC4 EAF1 2 Hazbun TR, et al. (2003)

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..95] deduced N/A No confident structure predictions are available.
    2 View Details [96..312] MSA 1.248995 View MSA. No confident structure predictions are available.
    3 View Details [313..480] Pfam 28.853872 No description for PF07529.1 was found. No confident structure predictions are available.
    4 View Details [481..707] deduced N/A No confident structure predictions are available.
    5 View Details [708..834] MSA 1.009975 View MSA. No confident structure predictions are available.
    6 View Details [835..982] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • histone acetyltransferase activity
    		•  5.78270240334849 bayes_pls_golite062009
  • lysine N-acetyltransferase activity
    		•  5.78270240334849 bayes_pls_golite062009
  • N-acyltransferase activity
    		•  4.53404381270892 bayes_pls_golite062009
  • N-acetyltransferase activity
    		•  4.38345537045529 bayes_pls_golite062009
  • acetyltransferase activity
    		•  3.81897719505269 bayes_pls_golite062009
  • acyltransferase activity
    		•  3.35931919126926 bayes_pls_golite062009
  • transferase activity, transferring acyl groups other than amino-acyl groups
    		•  3.31384699789032 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  3.09869056563841 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.05971315776284 bayes_pls_golite062009
  • DNA binding
    		•  2.98143466641891 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.85666780317594 bayes_pls_golite062009
  • binding
    		•  2.77786931095369 bayes_pls_golite062009
  • transcription factor activity
    		•  2.3234819540139 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.90050165838755 bayes_pls_golite062009
  • chromatin binding
    		•  1.46306211220814 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.23729321119532 bayes_pls_golite062009
  • protein deacetylase activity
    		•  1.23476914879396 bayes_pls_golite062009
  • histone deacetylase activity
    		•  1.18710646783152 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.02200659886159 bayes_pls_golite062009
  • protein binding
    		•  1.00288283679871 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.700409976805769 bayes_pls_golite062009
  • transcription activator activity
    		•  0.58607600202198 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.559482273209868 bayes_pls_golite062009
  • deacetylase activity
    		•  0.534082291544628 bayes_pls_golite062009
  • histone binding
    		•  0.489784140732052 bayes_pls_golite062009
  • transcription factor binding
    		•  0.270053518126008 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.0110175210304684 bayes_pls_golite062009
    6 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle