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Protein Overview: GLC7

General Information:
Name(s) found: GLC7 / YER133W [SGD]
Description(s) found:
Found 31 descriptions.
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  • Type 1 serine/threonine protein phosphatase catalytic subunit, involved in many processes (eg: glycogen metabolism, sporulation, mitosis); accumulates at mating projections by interaction with Afr1p; interacts with many regulatory subunits [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 312 amino acids

    Gene Ontology:
    Cellular Component: protein phosphatase type 1 complex [IDALink to PubMed article]
    mRNA cleavage and polyadenylation specificity factor complex [IPILink to PubMed article]
    cellular bud neck [IDALink to PubMed article]
    spindle pole body [IDALink to PubMed article]
    nuclear outer membrane [IMPLink to PubMed article]
    nucleolus [IDALink to PubMed article]
    mating projection base [IDALink to PubMed article]
    Biological Process: mitotic cell cycle spindle assembly checkpoint [IMPLink to PubMed article]
    cell morphogenesis during vegetative growth [IGILink to PubMed article]
    protein amino acid dephosphorylation [IDALink to PubMed article]
    chromosome segregation [IMPLink to PubMed article]
    cell budding [IMPLink to PubMed article]
    cellular ion homeostasis [IMPLink to PubMed article]
    meiosis [IPILink to PubMed article]
    regulation of carbohydrate metabolic process [IGILink to PubMed article][IPILink to PubMed article]
    ascospore formation [IMPLink to PubMed article]
    response to heat [IMPLink to PubMed article][IPILink to PubMed article]
    termination of RNA polymerase II transcription, poly(A)-coupled [IPILink to PubMed article]
    glycogen metabolic process [IMPLink to PubMed article]
    termination of RNA polymerase II transcription, poly(A)-independent [IPILink to PubMed article]
    histone dephosphorylation [IMPLink to PubMed article]
    Molecular Function: protein serine/threonine phosphatase activity [IDA]
    phosphoprotein phosphatase activity [IEA]
    RNA binding [RCA]
    metal ion binding [IEA]
    hydrolase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDSQPVDVDN IIDRLLEVRG SKPGQQVDLE ENEIRYLCSK ARSIFIKQPI LLELEAPIKI  60
   61 CGDIHGQYYD LLRLFEYGGF PPESNYLFLG DYVDRGKQSL ETICLLLAYK IKYPENFFIL 120
  121 RGNHECASIN RIYGFYDECK RRYNIKLWKT FTDCFNCLPI AAIIDEKIFC MHGGLSPDLN 180
  181 SMEQIRRVMR PTDIPDVGLL CDLLWSDPDK DIVGWSENDR GVSFTFGPDV VNRFLQKQDM 240
  241 ELICRAHQVV EDGYEFFSKR QLVTLFSAPN YCGEFDNAGA MMSVDESLLC SFQILKPAQK 300
  301 SLPRQAGGRK KK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ADE16 CFT1 CFT2 FIP1 FPR3 GLC7 GLC8 MPE1 PAP1 PFS2 PTA1 PTI1 REF2 REG1 RNA14 SDS22 SSU72 SWD2 SYC1 YSH1 YTH1
    View Details Hazbun TR, et al. (2003) GLC7 SDS22 YPI1
    View Details (MIPS) Mewes HW, et al. (2004) GAC1 GIP2 GLC7 GLC8 REG1 SDS22
    View Details Krogan NJ, et al. (2006) BNI4 BUD14 GIP3 GLC7 GLC8 HER1 PPZ1 PUF3 SDS22 SOL1 SOL2 YLR257W YPI1
    View Details Gavin AC, et al. (2006) ADE16 GLC7 SOL2
    View Details Gavin AC, et al. (2002) ACT1 ADE4 AIM31 BFR2 BMS1 BUD21 CBF5 CFT1 CFT2 CKA1 CLP1 DBP8 DIP2 ECM16 ECM29 EMG1 ENO2 ENP1 ENP2 ERO1 ESF1 ESF2 FIP1 GCN1 GLC7 HAS1 HCA4 HHF1, HHF2 HSL1 HTA1 HTA2 IMP3 IMP4 KRE33 KRR1 MPE1 MPP10 MVD1 NAN1 NOC4 NOP1 NOP12 NOP14 NOP56 NOP58 NOP6 PAP1 PCF11 PFK1 PFS2 PRE6 PRE9 PRP43 PTA1 PTI1 PWP2 REF2 RML2 RNA14 RNA15 ROK1 RPP2B RRP9 RSA3 RTG2 SCL1 SDS22 SEC13 SEC21 SEC31 SOF1 SRO9 SSA3 SSU72 SYC1 TAF6 TIF1, TIF2 TIF4632 TYE7 UTP10 UTP11 UTP13 UTP15 UTP18 UTP20 UTP21 UTP22 UTP30 UTP4 UTP6 UTP7 UTP8 UTP9 VID24 VMR1 VPS53 YCL046W YSH1 YTH1
    View Details Ho Y, et al. (2002) ADH4 ADK1 ATP3 ATP5 ATP7 CDC14 CDC25 CFT1 CIC1 CKA2 CLU1 DCP2 DPM1 EDC3 EDE1 ENP1 ERB1 FIN1 FIP1 FPR3 FPR4 FUR1 GDB1 GIP2 GLC7 GLC8 GPH1 GSY1 GSY2 HEF3 HER1 HMS1 HRR25 HXT6 KEL1 KOG1 MCR1 MDH1 MDS3 MGE1 MHP1 NET1 NOP6 NOP7 NSA1 NSR1 PDC5 PHO85 PMA1 PMA2 PPZ2 REG1 RPM2 RRP17 RSE1 RVB1 SCD5 SDS22 SEC23 SEN1 SFB3 SGM1 SIT4 SNF4 SPB1 SPE3 SSZ1 SUI2 SUI3 TGL1 TPS1 TSA2 TSR1 VAS1 YGR130C YPI1 YTM1
    View Details Qiu et al. (2008) GAC1 GLC7 PPH22 REF2 RTS1 RTS3

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run YPI1 No Comments Hazbun TR, et al. (2003)
    View Run YPI1 No Comments Hazbun TR, et al. (2003)
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run MLP2 #20 Asynchronous Prep1-TiO2 Phosphopeptide enrichment, PartB Keck JM, et al. (2011)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen YPI1 GLC7 2 Hazbun TR, et al. (2003)
    View Screen GLC7 BNI4 2 Uetz P, et al. (2000)
    View Screen GLC7 NFI1 2 Unpublished Fields Lab Data
    View Screen GLC7 GIP1 2 Uetz P, et al. (2000)
    View Screen GLC7 GEP4 2 Uetz P, et al. (2000)
    View Screen GLC7 BDF2 2 Uetz P, et al. (2000)
    View Screen GLC7 PAN1 2 Uetz P, et al. (2000)
    View Screen GLC7 SFG1 2 Uetz P, et al. (2000)
    View Screen GLC7 MHP1 2 Uetz P, et al. (2000)
    View Screen GLC7 SCD5 2 Uetz P, et al. (2000)
    View Screen GLC7 FIN1 2 Uetz P, et al. (2000)
    View Screen GLC7 REF2 2 Uetz P, et al. (2000)
    View Screen GLC7 RRP17 2 Uetz P, et al. (2000)

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data GLC7 Huh WK, et al. (2003)
    View Data GLC7 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..312] PSI-BLAST 1734.0 Protein phosphatase-1 (PP-1)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphoprotein phosphatase activity
    		•  11.6417995308386 bayes_pls_golite062009
  • protein serine/threonine phosphatase activity
    		•  10.6440947462013 bayes_pls_golite062009
  • phosphatase activity
    		•  10.5525832502704 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  10.3702645338723 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  9.02791306892273 bayes_pls_golite062009
  • calcium-dependent protein serine/threonine phosphatase activity
    		•  6.04386346716682 bayes_pls_golite062009
  • myosin phosphatase activity
    		•  5.31703100176823 bayes_pls_golite062009
  • hydrolase activity
    		•  3.13006743434485 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.68552051869632 bayes_pls_golite062009
  • kinase activity
    		•  1.67788383575784 bayes_pls_golite062009
  • structural molecule activity
    		•  1.5850868178597 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.57807175808088 bayes_pls_golite062009
  • protein kinase activity
    		•  1.4514460578232 bayes_pls_golite062009
  • binding
    		•  1.44538582463569 bayes_pls_golite062009
  • catalytic activity
    		•  1.39852585255405 bayes_pls_golite062009
  • transferase activity
    		•  1.3407391509244 bayes_pls_golite062009
  • protein binding
    		•  1.33435965029646 bayes_pls_golite062009
  • transporter activity
    		•  1.24767072239634 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.08090214431427 bayes_pls_golite062009
  • signal transducer activity
    		•  1.08090214431427 bayes_pls_golite062009
  • calmodulin binding
    		•  0.77173071932406 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.66803085638835 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.528189469950839 bayes_pls_golite062009
  • structural constituent of muscle
    		•  0.126411744957937 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle