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Protein Overview: UBP6

General Information:
Name(s) found: UBP6 / YFR010W [SGD]
Description(s) found:
Found 31 descriptions.
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  • Ubiquitin-specific protease situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains; works in opposition to polyubiquitin elongation activity of Hul5p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 499 amino acids

    Gene Ontology:
    Cellular Component: proteasome regulatory particle [IPILink to PubMed article]
    Biological Process: protein deubiquitination [TASLink to PubMed article]
    Molecular Function: ubiquitin-specific protease activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGETFEFNI RHSGKVYPIT LSTDATSADL KSKAEELTQV PSARQKYMVK GGLSGEESIK  60
   61 IYPLIKPGST VMLLGTPDAN LISKPAKKNN FIEDLAPEQQ VQQFAQLPVG FKNMGNTCYL 120
  121 NATLQALYRV NDLRDMILNY NPSQGVSNSG AQDEEIHKQI VIEMKRCFEN LQNKSFKSVL 180
  181 PIVLLNTLRK CYPQFAERDS QGGFYKQQDA EELFTQLFHS MSIVFGDKFS EDFRIQFKTT 240
  241 IKDTANDNDI TVKENESDSK LQCHISGTTN FMRNGLLEGL NEKIEKRSDL TGANSIYSVE 300
  301 KKISRLPKFL TVQYVRFFWK RSTNKKSKIL RKVVFPFQLD VADMLTPEYA AEKVKVRDEL 360
  361 RKVEKEKNEK EREIKRRKFD PSSSENVMTP REQYETQVAL NESEKDQWLE EYKKHFPPNL 420
  421 EKGENPSCVY NLIGVITHQG ANSESGHYQA FIRDELDENK WYKFNDDKVS VVEKEKIESL 480
  481 AGGGESDSAL ILMYKGFGL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ECM29 GSG1 NAS6 OSH7 POL4 RPN1 RPN10 RPN11 RPN12 RPN13 RPN2 RPN3 RPN5 RPN6 RPN7 RPN8 RPN9 RPT1 RPT2 RPT3 RPT4 RPT5 RPT6 SEC18 SEM1 SLX5 SPG5 SWA2 UBP6 URA3 VPS45
    View Details Krogan NJ, et al. (2006) CSI1 CSN9 ERV46 FPR2 HUL5 IQG1 MOT1 MPT5 NAS6 NMD3 NPT1 PCI8 PEP1 PST1 PUS9 RPN1 RPN10 RPN11 RPN12 RPN13 RPN14 RPN2 RPN5 RPN6 RPN7 RPN8 RPN9 RPT1 RPT2 RPT3 RPT4 RPT5 RPT6 RRI1 RRI2 SEC18 SEM1 SKP1 SPG5 SPO77 SQT1 SWA2 TCB2 TIP41 TOD6 TOR2 TSR4 UBP6 YEN1 YKL027W YMR258C YNL022C YPR003C YPT52
    View Details Gavin AC, et al. (2002) BLM10 CDC6 ECM29 GFA1 MLH2 NAS6 PGK1 PRE1 PRE10 PRE2 PRE3 PRE4 PRE5 PRE6 PRE7 PRE8 PRE9 PUP3 RGR1 RPN10 RPN11 RPN12 RPN13 RPN3 RPN5 RPN6 RPN7 RPN8 RPN9 RPT1 RPT2 RPT3 RPT4 RPT5 RPT6 SCL1 UBP6 YFL006W
    View Details Qiu et al. (2008) DOA4 RPN12 RPN13 RPT1 RPT2 RPT3 RPT4 RPT5 RPT6 UBP6

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen UBP6 CYS3 2 Unpublished Fields Lab Data
    View Screen UBP6 YIL168W 2 Unpublished Fields Lab Data
    View Screen UBP6 CSR2 2 Unpublished Fields Lab Data
    View Screen UBP6 BNA4 2 Unpublished Fields Lab Data
    View Screen UBP6 TSC13 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data UBP6 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..80] PSI-BLAST 8.39794 Ubiquitin
    2 View Details [81..155] Pfam 14.031517 No description for PF00442 was found. No confident structure predictions are available.
    3 View Details [156..425] MSA 6.241996 View MSA. No confident structure predictions are available.
    4 View Details [426..499] Pfam 29.619789 Ubiquitin carboxyl-terminal hydrolase No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • small conjugating protein ligase activity
    		•  3.22676362920771 bayes_pls_golite062009
  • hydrolase activity
    		•  2.77871378503369 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  2.46621820231139 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  2.24025972049145 bayes_pls_golite062009
  • binding
    		•  2.19381585790185 bayes_pls_golite062009
  • protein tag
    		•  1.93603588492737 bayes_pls_golite062009
  • protein binding
    		•  1.84908810286528 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  1.54640383227873 bayes_pls_golite062009
  • SUMO ligase activity
    		•  0.58905960362002 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.536856055841234 bayes_pls_golite062009
  • kinase activity
    		•  0.506057697290914 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.410719674374641 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.383121378043805 bayes_pls_golite062009
  • protein kinase activity
    		•  0.325253662829604 bayes_pls_golite062009
  • transferase activity
    		•  0.236208643697075 bayes_pls_golite062009
  • DNA binding
    		•  0.0840213088061073 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.0485636215870291 bayes_pls_golite062009
    2
    Term Confidence Notes
  • peptidase activity
    		•  7.38847948226412 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  7.21002260103248 bayes_pls_golite062009
  • endopeptidase activity
    		•  6.57191549077589 bayes_pls_golite062009
  • cysteine-type peptidase activity
    		•  6.54685807643041 bayes_pls_golite062009
  • small conjugating protein-specific protease activity
    		•  6.39247995905454 bayes_pls_golite062009
  • ubiquitin-specific protease activity
    		•  5.91394445088241 bayes_pls_golite062009
  • hydrolase activity
    		•  4.82615927403291 bayes_pls_golite062009
  • ubiquitin thiolesterase activity
    		•  4.1832081096766 bayes_pls_golite062009
  • thiolester hydrolase activity
    		•  2.96735553959103 bayes_pls_golite062009
  • SUMO-specific protease activity
    		•  2.65263825059319 bayes_pls_golite062009
  • cysteine-type endopeptidase activity
    		•  1.95802900199539 bayes_pls_golite062009
  • binding
    		•  1.3276268995308 bayes_pls_golite062009
  • catalytic activity
    		•  1.05972260874031 bayes_pls_golite062009
  • protein binding
    		•  0.854677025220204 bayes_pls_golite062009
  • NEDD8-specific protease activity
    		•  0.687958315289315 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  0.495951820083869 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.467924587720185 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.439226369799415 bayes_pls_golite062009
  • calcium-dependent cysteine-type endopeptidase activity
    		•  0.196538841514154 bayes_pls_golite062009
  • DNA binding
    		•  0.168761518285256 bayes_pls_golite062009
  • transferase activity
    		•  0.0852393573521809 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle