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Protein Overview: YPP1

General Information:
Name(s) found: YPP1 / YGR198W [SGD]
Description(s) found:
Found 30 descriptions.
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  • Cargo-transport protein involved in endocytosis; interacts with phosphatidylinositol-4-kinase Stt4; GFP-fusion protein localizes to the cytoplasm; YGR198W is an essential gene [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 817 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    ribosome [IDALink to PubMed article]
    plasma membrane [IDALink to PubMed article]
    Biological Process: MAPKKK cascade [IPILink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPNSNVRIPP TVPSKIIDVV DQALRARLLG GSTFNSGFDS LDSVLNLQFR LHYHVIGSNG  60
   61 PAKPVCDVLL KESQNLEKNM SMMEELNDYP EITKLVEKIL FNCLGILFFH RGQFQESQRC 120
  121 LLHSLKIHNN TASQKTALME QYDRYLIVEN LYYRGLVSQD INIMQNVFYK ELLAHVDTIP 180
  181 PESNGLLFEY ISLIVAKLRF NQIQDLAENF KTTVENPFIL FLYMIKKFQS PLKKHIDNDD 240
  241 LYLKFGQNVL LKAKFPTASE TNDEALEHFN VFLQYYFKFT HIKKIKVNPS WYNFIISSME 300
  301 KTFQSIEVSK TAMFLFQNLS DNSNDEIKKK TFKRESILNF VNFVKYNDKY YQLHDNSHRD 360
  361 IISFIDAYSF ILQNSSKTDS IENVFDYDNT VSTFATSLNS FYKEYNLPLM SQSESLDWLE 420
  421 NSTRCVYPGN ISKVLTNAWS TLYEIRKYQL DFLVSNNLTS YLCNAMMLST KEKDNADVEE 480
  481 QEEGEEEKAL RELQFKYSYT LAQQRHIETA IKTLESLILS KNPNYYKAWH LLALCRSVQE 540
  541 DKEMSYKIVC SVLEAMNESL QNNTLLLNDR WQFIHLKLTQ LALIEEIFGT LEALETLPEV 600
  601 FELYATLFPD SQPELNSMGP KYSQTKEYLL QMVWIFAANM YMRTKDNDED AKAAIKEASN 660
  661 VESKFKNLNC NIANGYLSII KDEPGVALKE FETVLYYDEN NLDALVGFAE LIFPEELGVE 720
  721 ETNLERYYTL SLDKKPGKRA KLTFVNDTDR SAAYARLKFL LECAILESIE AYYSPEVWWY 780
  781 LSLIYEKYQD DEYKNSLLKC IKYQELNPIR SLRYCNY

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Hazbun TR, et al. (2003) STT4 YPP1
    View Details Krogan NJ, et al. (2006) ARC15 ASR1 CAJ1 CDC7 CRN1 INP52 IRC22 MSK1 PNO1 PST2 RAD34 SAC6 SAR1 SLM1 TCP1 TED1 YPP1
    View Details Ho Y, et al. (2002) CBF5 CBP2 CCM1 CDC33 CIC1 DBP7 ENP2 GBP2 HAS1 HMO1 HTB2 IMD1 IMD3 ISA1 KRE33 KRI1 MGM101 MSS116 NOC2 NOP12 NOP6 NPL3 PET127 POL5 PRP43 PUF6 PWP1 RLI1 RRP12 RRP5 TIF4631 TRA1 TSR1 URB1 URB2 UTP10 UTP20 YPP1 YRA1 YTM1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run YPP1 No Comments Hazbun TR, et al. (2003)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen YPP1 YBR138C 2 Hazbun TR, et al. (2003)

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data YPP1 and SPC42 Hazbun TR, et al. (2003)
    View Data YPP1 and TRX3 Hazbun TR, et al. (2003)
    View Data YPP1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..179] PSI-BLAST 15.221849 Hop
    2 View Details [180..257] deduced N/A No confident structure predictions are available.
    3 View Details [258..403] PSI-BLAST 30.0 Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
    4 View Details [404..471] PSI-BLAST 30.0 Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
    5 View Details [472..608] PSI-BLAST 30.0 Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
    6 View Details [609..817] MSA 1.657995 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • signal sequence binding
    		•  2.68460419248567 bayes_pls_golite062009
  • binding
    		•  2.29041171814244 bayes_pls_golite062009
  • protein binding
    		•  1.6279032205159 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.36301889945421 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.04482640570705 bayes_pls_golite062009
  • DNA binding
    		•  1.03582297487751 bayes_pls_golite062009
  • peroxisome targeting sequence binding
    		•  1.01220052237687 bayes_pls_golite062009
  • ligase activity
    		•  0.825764637499128 bayes_pls_golite062009
  • RNA binding
    		•  0.540255067346835 bayes_pls_golite062009
  • transcription factor activity
    		•  0.39224150319016 bayes_pls_golite062009
  • signal transducer activity
    		•  0.279505673062022 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.279505673062022 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle