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Protein Overview: LSM12

General Information:
Name(s) found: LSM12 / YHR121W [SGD]
Description(s) found:
Found 31 descriptions.
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  • Protein of unknown function that may function in RNA processing; interacts with Pbp1p and Pbp4p and associates with ribosomes; contains an RNA-binding LSM domain and an AD domain; GFP-fusion protein is induced by the DNA-damaging agent MMS [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 187 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    ribosome [IDALink to PubMed article]
    Biological Process: RNA metabolic process [IPILink to PubMed article][ISSLink to PubMed article]
    Molecular Function: RNA binding [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVSLEQTLG FRIKVTNVLD VVTEGRLYSF NSSNNTLTIQ TTKKNQSPQN FKVIKCTFIK  60
   61 HLEVIGDKPS FNSFKKQQIK PSYVNVERVE KLLKESVIAS KKKELLRGKG VSAEGQFIFD 120
  121 QIFKTIGDTK WVAKDIIILD DVKVQPPYKV EDIKVLHEGS NQSITLIQRI VERSWEQLEQ 180
  181 DDGRKGG

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) IRC8 LSM12 RPL38 YLL032C
    View Details Gavin AC, et al. (2006) LSM12 PBP1
    View Details Gavin AC, et al. (2002) AVO1 BEM2 CEG1 CET1 CLU1 CTR9 HHF1, HHF2 LSM12 NIP1 NOP1 PDB1 PRP43 PUF3 RPG1 SPT16 SSA3 SSA4 TOP2 TUB3 VPS1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen LSM12 PBP1 2 Unpublished Fields Lab Data
    View Screen LSM12 ETP1 2 Unpublished Fields Lab Data
    View Screen LSM12 EGD1 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data LSM12 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..187] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
    		• 4.07740034050179 bayes_pls_golite062009
  • RNA binding
    		•  3.27319059794493 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.61608895983631 bayes_pls_golite062009
  • binding
    		•  1.98357769931197 bayes_pls_golite062009
  • mRNA binding
    		•  0.315204974525072 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle