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Protein Overview: ATG7

General Information:
Name(s) found: ATG7 / YHR171W [SGD]
Description(s) found:
Found 26 descriptions.
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  • Autophagy-related protein and dual specificity member of the E1 family of ubiquitin-activating enzymes; mediates the conjugation of Atg12p with Atg5p and Atg8p with phosphatidylethanolamine, required steps in autophagosome formation [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 630 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    membrane [IDALink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: autophagy [IMPLink to PubMed articleLink to PubMed article]
    protein modification process [IMPLink to PubMed articleLink to PubMed article][IPILink to PubMed article][ISSLink to PubMed article]
    C-terminal protein lipidation [IDALink to PubMed article][IMPLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed article]
    protein targeting to vacuole [IMPLink to PubMed articleLink to PubMed article]
    CVT pathway [IMPLink to PubMed article]
    Molecular Function: APG8 activating enzyme activity [IMPLink to PubMed article][IPILink to PubMed article]
    APG12 activating enzyme activity [IMPLink to PubMed article][IPILink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSERVLSYA PAFKSFLDTS FFQELSRLKL DVLKLDSTCQ PLTVNLDLHN IPKSADQVPL  60
   61 FLTNRSFEKH NNKRTNEVPL QGSIFNFNVL DEFKNLDKQL FLHQRALECW EDGIKDINKC 120
  121 VSFVIISFAD LKKYRFYYWL GVPCFQRPSS TVLHVRPEPS LKGLFSKCQK WFDVNYSKWV 180
  181 CILDADDEIV NYDKCIIRKT KVLAIRDTST MENVPSALTK NFLSVLQYDV PDLIDFKLLI 240
  241 IRQNEGSFAL NATFASIDPQ SSSSNPDMKV SGWERNVQGK LAPRVVDLSS LLDPLKIADQ 300
  301 SVDLNLKLMK WRILPDLNLD IIKNTKVLLL GAGTLGCYVS RALIAWGVRK ITFVDNGTVS 360
  361 YSNPVRQALY NFEDCGKPKA ELAAASLKRI FPLMDATGVK LSIPMIGHKL VNEEAQHKDF 420
  421 DRLRALIKEH DIIFLLVDSR ESRWLPSLLS NIENKTVINA ALGFDSYLVM RHGNRDEQSS 480
  481 KQLGCYFCHD VVAPTDSLTD RTLDQMCTVT RPGVAMMASS LAVELMTSLL QTKYSGSETT 540
  541 VLGDIPHQIR GFLHNFSILK LETPAYEHCP ACSPKVIEAF TDLGWEFVKK ALEHPLYLEE 600
  601 ISGLSVIKQE VERLGNDVFE WEDDESDEIA

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) ATG7 NOP2 TIF6 ULS1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen SST2 ATG7 2 Unpublished Fields Lab Data
    View Screen SSO2 ATG7 2 Drees BL, et al. (2001)
    View Screen IMP4 ATG7 2 Unpublished Fields Lab Data
    View Screen ATG7 OCT1 2 Unpublished Fields Lab Data
    View Screen RRP17 ATG7 2 Unpublished Fields Lab Data
    View Screen DOC1 ATG7 2 Unpublished Fields Lab Data
    View Screen ATG7 GIS2 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..293] deduced N/A No confident structure predictions are available.
    2 View Details [294..630] PSI-BLAST 166.30103 Molybdenum cofactor biosynthesis protein MoeB
    3 View Details [300..630] PSI-BLAST 69.39794 Molybdenum cofactor biosynthesis protein MoeB

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • small protein activating enzyme activity
    		•  3.58068602287881 bayes_pls_golite062009
  • NEDD8 activating enzyme activity
    		•  2.11391077579348 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  1.84216910649062 bayes_pls_golite062009
  • binding
    		•  1.66028321721112 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.54883560427918 bayes_pls_golite062009
  • protein binding
    		•  1.40907622346701 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.31244773198273 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  1.27535252106053 bayes_pls_golite062009
  • catalytic activity
    		•  1.22201444897049 bayes_pls_golite062009
  • transferase activity
    		•  0.680338489823338 bayes_pls_golite062009
  • URM1 activating enzyme activity
    		•  0.207228630005671 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle