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Protein Overview: TEF4

General Information:
Name(s) found: TEF4 / YKL081W [SGD]
Description(s) found:
Found 22 descriptions.
SHOW ALL
  • Translation elongation factor EF-1 gamma [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 412 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed article]
    ribosome [TASLink to PubMed article]
    eukaryotic translation elongation factor 1 complex [ISSLink to PubMed article]
    Biological Process: translational elongation [TASLink to PubMed article]
    Molecular Function: translation elongation factor activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQGTLYINR SPRNYASEAL ISYFKLDVKI VDLEQSSEFA SLFPLKQAPA FLGPKGLKLT  60
   61 EALAIQFYLA NQVADEKERA RLLGSDVIEK SQILRWASLA NSDVMSNIAR PFLSFKGLIP 120
  121 YNKKDVDACF VKIDNLAAVF DARLRDYTFV ATENISLGDL HAAGSWAFGL ATILGPEWRA 180
  181 KHPHLMRWFN TVAASPIVKT PFAEVKLAEK ALTYTPPKKQ KAEKPKAEKS KAEKKKDEAK 240
  241 PADDAAPAKK PKHPLEALGK STFVLDDWKR KYSNDDTRPV ALPWFWEHYN PEEYSIWKVG 300
  301 YKYNDELTLT FMSNNLVGGF FNRLSASTKY MFGCLVVYGE NNNNGIVGAV MVRGQDFAPA 360
  361 FDVAPDWESY EYTKLDPTKE EDKEFVNNMW AWDKPVVVNG EDKEIVDGKV LK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CAM1 EFB1 GUS1 HSP104 HYP2 SSZ1 TEF4 YEF3 ZUO1
    View Details (MIPS) Mewes HW, et al. (2004) CAM1 EFB1 HBS1 TEF1, TEF2 TEF4
    View Details Krogan NJ, et al. (2006) ARO4 CAM1 TEF4 TMA19
    View Details Gavin AC, et al. (2006) ERG1 OLA1 TEF4
    View Details Gavin AC, et al. (2002) ADA2 ADH1 BLM10 CAM1 CDC55 CIN1 CLU1 EFB1 ERG13 FAP1 FUN19 GCN5 GFA1 GUS1 HEM13 HHF1, HHF2 HOS2 HOS4 ILV1 IML1 KAP114 KAP123 KAP95 KEL1 LTE1 MED4 MES1 MGA2 MNN4 MOT1 MYO1 MYO5 NEW1 NGG1 NOP1 OLA1 PFK1 PFK2 PPH21 PPH22 PRE1 PRE10 PRE2 PRE4 PRE5 PRE6 PRE7 PRE8 PRE9 PSK1 PTC1 PUF6 PUP1 PUP2 PUP3 RPB2 RPN9 RPO21 RPT5 RRD2 RTS1 RTS3 RVB2 SBP1 SCL1 SEC27 SET3 SGF29 SGF73 SIF2 SIN3 SIN4 SNT1 SPT15 SPT20 SPT7 SPT8 SRP1 TAF1 TAF10 TAF11 TAF12 TAF13 TAF14 TAF2 TAF3 TAF4 TAF5 TAF6 TAF7 TAF8 TAF9 TBF1 TDH2 TDH3 TEF1, TEF2 TEF4 TPD3 VAS1 VPS1 YBL104C YOR1 YRA1 ZDS1 ZDS2
    View Details Ho Y, et al. (2002) AAC3 AAT2 ACH1 ACO1 ADH2 ADH4 ADH6 AFR1 AHA1 AHP1 AIM21 ARC1 ARF1 ATP3 BEM2 BIO3 BUD14 BUD20 CAR2 CDC15 CDC33 CDC53 CIC1 CLU1 CMD1 CMP2 COF1 COR1 CPR1 CPR3 CYR1 CYS4 DOG1 DUG2 DUT1 ECM10 EGD1 EHD3 ERG13 ERG20 ERG6 FPR1 FRS2 GAS1 GCD11 GDI1 GIS4 GND1 GND2 GPI15 GRX1 GUS1 HEF3 HHF1, HHF2 HMO1 HOM3 HOR2 HSP104 HTB1 HTB2 HYP2 IDH1 ILV2 ILV5 KEL1 KEL2 KGD1 KIN2 KRE6 LRO1 LSM2 LSP1 MAM33 MDH1 MET30 MET31 MET4 MET6 MGM101 MRPS16 NTF2 OLA1 OYE2 PFK1 PIL1 POP2 PRB1 PRM2 PTC3 PTC7 QCR2 RAD26 RAD3 RAD52 RAD59 RFC3 RHR2 RLP24 RNR2 RPN7 RSN1 RUB1 SAH1 SCP160 SEC27 SEC53 SEN15 SES1 SIR1 SIR3 SIS1 SKP1 SNU13 SOD1 TEF4 TEM1 TFC4 TFP1 THS1 TIF1, TIF2 TMA19 TMA29 TSA2 UBA1 UTP20 VMA4 VMA5 VMA8 WTM1 YER138C YFL006W YGR066C YNK1 YPT31 YSP2
    View Details Qiu et al. (2008) CAM1 EFB1 TEF1, TEF2 TEF4

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run YMR185W No Comments Hazbun TR, et al. (2003)
    View Run MIA40 No Comments Hazbun TR, et al. (2003)
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run BOI1 Sample boi 1 with ha tag from october 2005 McCusker D, et al (2007)
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #35 Asynchronous SPB prep Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data TEF4 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..80] PSI-BLAST 66.533179 Class phi GST
    2 View Details [81..247] PSI-BLAST 66.533179 Class phi GST
    3 View Details [248..412] Pfam 81.920819 Elongation factor 1 gamma, conserved domain No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  2.30799114442278 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.06381591939564 bayes_pls_golite062009
  • DNA binding
    		•  1.92118545500784 bayes_pls_golite062009
  • binding
    		•  1.25802922431343 bayes_pls_golite062009
  • transcription activator activity
    		•  1.23146660729357 bayes_pls_golite062009
  • protein binding
    		•  1.18479617596618 bayes_pls_golite062009
  • catalytic activity
    		•  0.672192331361968 bayes_pls_golite062009
  • RNA binding
    		•  0.382017633056715 bayes_pls_golite062009
    		• 0.359224524631956 bayes_pls_golite062009
  • receptor binding
    		•  0.0497559408754589 bayes_pls_golite062009
    2
    Term Confidence Notes
  • translation elongation factor activity
    		•  11.9602302019768 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  7.4644014407268 bayes_pls_golite062009
  • translation regulator activity
    		•  7.42485540728491 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.9329721501879 bayes_pls_golite062009
  • binding
    		•  3.0325775548747 bayes_pls_golite062009
  • protein binding
    		•  1.65598815428763 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle