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Protein Overview: YJU2

General Information:
Name(s) found: YJU2 / YKL095W [SGD]
Description(s) found:
Found 27 descriptions.
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  • Essential protein required for pre-mRNA splicing; associates transiently with the spliceosomal NTC ("nineteen complex") and acts after Prp2p to promote the first catalytic reaction of splicing [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 278 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    Biological Process: nuclear mRNA splicing, via spliceosome [RCALink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSERKAINKY YPPDYNPLEA EKLSRKMAKK LKTMNKSHAS IRLMTPFSMR CLECNEYIPK  60
   61 SRKFNGKKEL LKEKYLDSIK IYRLTISCPR CANSIAFRTD PGNSDYVMEV GGVRNYVPQK 120
  121 PNDDLNAKTA VESIDETLQR LVREKEMEQN EKMGIKEQAD DKMDLLEKRL AKIQQEQEDD 180
  181 EELENLRKKN LEMSQRAEMI NRSKHAQQEK AVTTDDLDNL VDQVFDNHRQ RTNKPGNNND 240
  241 EKRTPLFNPT STKGKIQKKS SVRTNPLGIV IKRGKSLK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Hazbun TR, et al. (2003) BRR2 CDC40 CEF1 CLF1 CWC2 CWC22 CWC23 ECM2 ISY1 LEA1 NTR2 PRP19 PRP43 PRP45 PRP46 PRP8 SMB1 SMD1 SMD3 SNT309 SNU114 SPP382 SYF1 SYF2 YJU2
    View Details Krogan NJ, et al. (2006) AAR2 BRR1 BRR2 CSE1 LUC7 MUD1 NAM8 PRP2 PRP3 PRP31 PRP39 PRP40 PRP42 PRP6 PRP8 RRG7 SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNP1 SNU114 SNU56 SNU66 SNU71 TAD2 YDL085C-A YHC1 YJU2 YNL092W
    View Details Ho Y, et al. (2002) CCT5 COR1 DED81 DUN1 EGD1 GCD11 NAP1 NMD3 PRP19 QCR2 SOD1 TCP1 TIF1, TIF2 YJU2 YNK1
    View Details Qiu et al. (2008) PRP2 PRP5 SLU7 YHC1 YJU2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CWC2 No Comments Hazbun TR, et al. (2003)
    View Run CWC25 No Comments Hazbun TR, et al. (2003)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen YJU2 URE2 2 Uetz P, et al. (2000)
    View Screen YJU2 YDR199W 2 Unpublished Fields Lab Data
    View Screen YJU2 SYF1 2 Uetz P, et al. (2000)

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data YJU2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..212] MSA 11.018955 View MSA. No confident structure predictions are available.
    2 View Details [213..278] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  2.74510263950241 bayes_pls_golite062009
  • DNA binding
    		•  2.44566855074341 bayes_pls_golite062009
  • binding
    		•  2.27558039325716 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.24669580094588 bayes_pls_golite062009
  • transcription factor activity
    		•  1.9022303099625 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.911347670379084 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.839985608194026 bayes_pls_golite062009
  • transcription activator activity
    		•  0.685318320359585 bayes_pls_golite062009
  • protein binding
    		•  0.606784236996154 bayes_pls_golite062009
  • transcription factor binding
    		•  0.50605454225389 bayes_pls_golite062009
  • ligand-dependent nuclear receptor activity
    		•  0.296219659608347 bayes_pls_golite062009
  • catalytic activity
    		•  0.133319360419662 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle