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Protein Overview: LIP2

General Information:
Name(s) found: LIP2 / YLR239C [SGD]
Description(s) found:
Found 22 descriptions.
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  • Lipoyl ligase, involved in the modification of mitochondrial enzymes by the attachment of lipoic acid groups [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 328 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed articleLink to PubMed article]
    Biological Process: protein lipoylation [IMPLink to PubMed article][ISSLink to PubMed article]
    Molecular Function: ligase activity [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRCIRQSVC TNFNVCRRQC FSTYASALKE MTHPIKPSAQ TLRHLQFTQR IPFQKGLEIQ  60
   61 ETLVRANLDI KDIQSKIERK LIQLDEEYKG TATINDNEKR ILDKVMAMKP NPIILTFEFE 120
  121 PTYTGGKRIK KTMTPDQIAA YESFIPETQK DNPRPKFVQV ERGGQVTFHG PGQIVIYIIL 180
  181 DLKTFQSFPA KCLVSCIEQA TIRTLKNTKM CDDTDKPLNL DAMTTKDTGV WVENGKKKVA 240
  241 SVGIHVRRSI TSHGVAINVN TDLSYMNSFE MCGLKNTLTT SIMEQRPDAV VNVQSVAISF 300
  301 VKEMTKLLGI KTLERMQIDD VNILKKNP

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) GCV3 LIP2
    View Details Gavin AC, et al. (2002) BDF2 CDC55 CKB1 DYN1 ECM5 GLY1 HAT1 HAT2 HHF1, HHF2 HIF1 HSM3 ICL1 IML1 KAP123 KRE33 LIP2 MAC1 MDN1 MIS1 MSB1 NIP1 NMD5 PFK1 PRO1 PRT1 PSD2 PSE1 PSH1 RPA135 RPC40 RPG1 RPN12 RPN3 RPN6 RPN8 RPN9 RPT2 RPT3 RPT5 RPT6 RSC3 SAM1 TEL1 TSC11 USO1 UTP20 VTH2 YFR006W YPR077C

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen MEC3 LIP2 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data LIP2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..109] MSA 1.038992 View MSA. No confident structure predictions are available.
    2 View Details [110..267] Pfam 30.481486 Biotin/lipoate A/B protein ligase family No confident structure predictions are available.
    3 View Details [268..328] MSA 1.043994 View MSA. Confident ab initio structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • aminoacyl-tRNA ligase activity
    		•  4.83057889638134 bayes_pls_golite062009
  • ligase activity, forming aminoacyl-tRNA and related compounds
    		•  4.8294067084702 bayes_pls_golite062009
  • ligase activity, forming carbon-oxygen bonds
    		•  4.8294067084702 bayes_pls_golite062009
  • ligase activity
    		•  3.51191116674556 bayes_pls_golite062009
  • catalytic activity
    		•  1.99372273395202 bayes_pls_golite062009
  • phenylalanine-tRNA ligase activity
    		•  1.57827239765705 bayes_pls_golite062009
  • serine-tRNA ligase activity
    		•  1.07048505740004 bayes_pls_golite062009
  • glycine-tRNA ligase activity
    		•  0.91005913703893 bayes_pls_golite062009
  • threonine-tRNA ligase activity
    		•  0.793195358470619 bayes_pls_golite062009
  • binding
    		•  0.521863822270226 bayes_pls_golite062009
  • alanine-tRNA ligase activity
    		•  0.435766663027965 bayes_pls_golite062009
  • histidine-tRNA ligase activity
    		•  0.334773354741163 bayes_pls_golite062009
  • lysine-tRNA ligase activity
    		•  0.333541891861949 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.281662799812287 bayes_pls_golite062009
  • ATP binding
    		•  0.18403217430648 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.145955341735342 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.134753238769136 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.127823774098159 bayes_pls_golite062009
  • DNA binding
    		•  0.0309732052586011 bayes_pls_golite062009
  • protein binding
    		•  0.0101455326199739 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle