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Protein Overview: RRB1

General Information:
Name(s) found: RRB1 / YMR131C [SGD]
Description(s) found:
Found 22 descriptions.
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  • Essential nuclear protein involved in early steps of ribosome biogenesis; physically interacts with the ribosomal protein Rpl3p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 511 amino acids

    Gene Ontology:
    Cellular Component: nucleolus [IDALink to PubMed article]
    Biological Process: ribosome biogenesis [IMPLink to PubMed article][IPILink to PubMed article][RCALink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKRSIEVNE EQDRVVSAKT ESHSVPAIPA SEEQDAPKND LEEQLSDEFD SDGEIIEIDG  60
   61 DDEINDEDDL RKKQEEAETL VQKDQSEGNK EKIQELYLPH MSRPLGPDEV LEADPTVYEM 120
  121 LHNVNMPWPC LTLDVIPDTL GSERRNYPQS ILLTTATQSS RKKENELMVL ALSNLAKTLL 180
  181 KDDNEGEDDE EDDEDDVDPV IENENIPLRD TTNRLKVSPF AISNQEVLTA TMSENGDVYI 240
  241 YNLAPQSKAF STPGYQIPKS AKRPIHTVKN HGNVEGYGLD WSPLIKTGAL LSGDCSGQIY 300
  301 FTQRHTSRWV TDKQPFTVSN NKSIEDIQWS RTESTVFATA GCDGYIRIWD TRSKKHKPAI 360
  361 SVKASNTDVN VISWSDKIGY LLASGDDNGT WGVWDLRQFT PSNADAVQPV AQYDFHKGAI 420
  421 TSIAFNPLDE SIVAVGSEDN TVTLWDLSVE ADDEEIKQQA AETKELQEIP PQLLFVHWQK 480
  481 EVKDVKWHKQ IPGCLVSTGT DGLNVWKTIS V

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) AMD1 RRB1 YJL070C
    View Details Qiu et al. (2008) DRS1 NAN1 NSR1 NUG1 PXR1 RRB1 UTP15 UTP4 UTP5

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #33 Asynchronous SPB prep Keck JM, et al. (2011)
    View Run MLP2 #19 Asynchronous Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #35 Asynchronous SPB prep Keck JM, et al. (2011)
    View Run MLP2 #04 Alpha Factor Prep2 Keck JM, et al. (2011)
    View Run MLP2 #06 Alpha Factor Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #19b Asynchronous Prep1-new search criteria Keck JM, et al. (2011)
    View Run MLP2 #19a Asynchronous Prep1-new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen RRB1 BDS1 2 Unpublished Fields Lab Data
    View Screen RRB1 YGR160W 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data RRB1 Huh WK, et al. (2003)
    View Data RRB1 and NOP56 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..181] MSA 1.673995 View MSA. No confident structure predictions are available.
    2 View Details [182..511] PSI-BLAST 87.70927 beta1-subunit of the signal-transducing G protein heterotrimer

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • histone methyltransferase activity (H3-K4 specific)
    		•  4.71992275913384 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  2.79445416141967 bayes_pls_golite062009
  • snoRNA binding
    		•  2.62514080753887 bayes_pls_golite062009
  • binding
    		•  2.42570478946173 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.3610959773142 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.30918780727915 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.29049708962212 bayes_pls_golite062009
  • S-adenosylmethionine-dependent methyltransferase activity
    		•  2.18628561734369 bayes_pls_golite062009
  • histone methyltransferase activity
    		•  1.85632145559025 bayes_pls_golite062009
  • DNA binding
    		•  1.71685536470455 bayes_pls_golite062009
  • dynein binding
    		•  1.62099593211487 bayes_pls_golite062009
  • transcription corepressor activity
    		•  1.41752877005447 bayes_pls_golite062009
  • protein methyltransferase activity
    		•  1.35170368882651 bayes_pls_golite062009
  • acetyltransferase activity
    		•  1.23134876981279 bayes_pls_golite062009
  • protein binding
    		•  1.21879977456466 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.19593750149343 bayes_pls_golite062009
  • lysine N-methyltransferase activity
    		•  1.15313682561559 bayes_pls_golite062009
  • histone-lysine N-methyltransferase activity
    		•  1.15313682561559 bayes_pls_golite062009
  • protein-lysine N-methyltransferase activity
    		•  1.15313682561559 bayes_pls_golite062009
  • transcription factor activity
    		•  1.08768505897883 bayes_pls_golite062009
  • transcription initiation factor activity
    		•  1.01962930136588 bayes_pls_golite062009
    		• 0.88172763425403 bayes_pls_golite062009
  • histone binding
    		•  0.685319917508843 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.676924760416604 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.625780732991652 bayes_pls_golite062009
  • actin binding
    		•  0.529861581509437 bayes_pls_golite062009
  • transcription factor binding
    		•  0.489473003915035 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  0.437810477160064 bayes_pls_golite062009
  • DNA polymerase activity
    		•  0.428715007921149 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.426429095658617 bayes_pls_golite062009
  • kinase activity
    		•  0.387572734234845 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.30761651528651 bayes_pls_golite062009
  • transporter activity
    		•  0.284701931503833 bayes_pls_golite062009
  • structural molecule activity
    		•  0.254012051644049 bayes_pls_golite062009
  • protein kinase activity
    		•  0.229242350006544 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.226335610368636 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.220747580531792 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.161639372576406 bayes_pls_golite062009
  • chromatin binding
    		•  0.151977098745772 bayes_pls_golite062009
  • N-methyltransferase activity
    		•  0.00335766408304172 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle