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Protein Overview: CKB2

General Information:
Name(s) found: CKB2 / YOR039W [SGD]
Description(s) found:
Found 36 descriptions.
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  • Beta' regulatory subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA1, CKA2 and CKB1, the many substrates include transcription factors and all RNA polymerases [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 258 amino acids

    Gene Ontology:
    Cellular Component: protein kinase CK2 complex [IDALink to PubMed article]
    Biological Process: G2/M transition of mitotic cell cycle [IPILink to PubMed article]
    G1/S transition of mitotic cell cycle [IPILink to PubMed article]
    flocculation via cell wall protein-carbohydrate interaction [IMPLink to PubMed article]
    protein amino acid phosphorylation [IDALink to PubMed article]
    response to DNA damage stimulus [IDALink to PubMed article]
    regulation of transcription from RNA polymerase III promoter [IDALink to PubMed article]
    regulation of transcription from RNA polymerase I promoter [IDALink to PubMed article]
    cellular ion homeostasis [IMPLink to PubMed article]
    Molecular Function: protein kinase CK2 regulator activity [IMPLink to PubMed article][IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGSRSENVGT VTREGSRVEQ DDVLMDDDSD SSEYVDMWID LFLGRKGHEY FCDVDPEYIT  60
   61 DRFNLMNLQK TVSKFSYVVQ YIVDDLDDSI LENMTHARLE QLESDSRKLY GLIHARYIIT 120
  121 IKGLQKMYAK YKEADFGRCP RVYCNLQQLL PVGLHDIPGI DCVKLYCPSC EDLYIPKSSR 180
  181 HSSIDGAYFG TSFPGMFLQA FPDMVPKHPT KRYVPKIFGF ELHKQAQLTR WQELQRLKLV 240
  241 EKLESKDVDL TKSGGFKT

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CAB3 CDC73 CHD1 CKA1 CKA2 CKB1 CKB2 CTR9 HOT1 LEO1 PAF1 POB3 RTF1 SPT16 UTP22
    View Details (MIPS) Mewes HW, et al. (2004) CKA1 CKA2 CKB1 CKB2
    View Details Krogan NJ, et al. (2006) CAB3 CHD1 CKA1 CKA2 CKB1 CKB2 ELF1 HOT1 MSC3 NRG1 PGA2 REH1 RIM13 VHS3 YLR407W
    View Details Gavin AC, et al. (2006) CKA1 CKA2 CKB1 CKB2
    View Details Gavin AC, et al. (2002) ABF2 ADE4 ASC1 BFR2 BMS1 BRX1 BUD21 CAB3 CBF5 CDC73 CHD1 CKA1 CKA2 CKB1 CKB2 CMS1 CTI6 CTR9 DBP8 DEP1 DIA4 DIM1 DIP2 DIS3 DOT6 EAF3 ECM16 ECM29 EMG1 ENP1 ENP2 ERO1 ESF1 ESF2 FAP7 GCN1 HCA4 HHF1, HHF2 HOT1 HSL1 HTA2 IML1 IMP3 IMP4 IOC3 ISW1 ISW2 KRE33 KRR1 LCP5 LEO1 LTV1 LYS12 MED4 MPP10 MRD1 MVD1 NAN1 NHP10 NIP1 NOB1 NOC2 NOC4 NOP1 NOP14 NOP56 NOP58 NOP6 NRD1 PAF1 PHO23 PNO1 POB3 PRE6 PRE9 PRP43 PRT1 PWP2 RCL1 RCO1 RET1 RML2 ROK1 RPD3 RPG1 RPP2B RRP12 RRP7 RRP9 RSC8 RTF1 RTG2 RVB2 RXT2 RXT3 SAM1 SAP30 SCL1 SDS3 SEC21 SIN3 SLX9 SOF1 SPT16 SSA4 STO1 TIF1, TIF2 TIF35 TOP1 TSR1 TUP1 UME1 UME6 UTP10 UTP11 UTP13 UTP15 UTP18 UTP20 UTP21 UTP22 UTP30 UTP4 UTP6 UTP7 UTP8 UTP9 VPS1 YOR059C YTA7
    View Details Ho Y, et al. (2002) ARO1 CDC28 CEG1 CIC1 CKA1 CKA2 CKB1 CKB2 CUE5 DBP10 DBP2 DIP2 EGD1 ENP2 ERB1 ESL2 FKH1 FPR3 FYV8 GCD2 GCD7 GCN3 GDE1 HAS1 HHF1, HHF2 HHT1, HHT2 HOT1 HTA1 HTB1 HTB2 KRE33 KRI1 LCP5 LSB3 MAM33 MBP1 MGM101 MPH1 MRPL1 NAN1 NET1 NOC3 NOG1 NOP1 NOP12 NOP2 NOP4 NOP56 NOP7 NUG1 PDI1 PNO1 POB3 POL2 PRP40 PTC5 PUF6 PWP1 PWP2 RPF2 RRP1 RRP14 RRP15 RRP5 SEC2 SFP1 SIN3 SPB1 SPT16 SRP1 SSF1 SUI2 SUI3 TFP1 TIF4631 TIF6 TRL1 UBP12 UBP15 URE2 UTP10 UTP11 UTP13 UTP14 UTP18 UTP21 UTP22 UTP30 UTP6 VMR1 VPS73 WTM2 YER084W YFR024C YGR017W YJL045W YLR422W YME2 YMR144W YRA1 YTM1
    View Details Qiu et al. (2008) CKA1 CKA2 CKB1 CKB2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen CKB2 CKA2 2 Unpublished Fields Lab Data
    View Screen CKB2 NIP100 2 Unpublished Fields Lab Data
    View Screen LSM4 CKB2 2 Uetz P, et al. (2000)
    View Screen CKA2 CKB2 2 Uetz P, et al. (2000)
    View Screen CKB1 CKB2 2 Unpublished Fields Lab Data
    View Screen NOG1 CKB2 2 Unpublished Fields Lab Data
    View Screen RHO3 CKB2 2 Unpublished Fields Lab Data
    View Screen CKB2 CKA1 2 Unpublished Fields Lab Data
    View Screen CKB2 CKB2 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data CKB2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..41]
    [55..110]    		 PSI-BLAST 630.0 Casein kinase II beta subunit
    2 View Details [42..54]
    [111..258]    		 PSI-BLAST 630.0 Casein kinase II beta subunit

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein kinase regulator activity
    		•  4.14878012076359 bayes_pls_golite062009
  • kinase regulator activity
    		•  4.09603095102334 bayes_pls_golite062009
  • enzyme regulator activity
    		•  2.91779610785511 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  2.79245883940915 bayes_pls_golite062009
  • protein kinase activity
    		•  2.75473427458132 bayes_pls_golite062009
  • kinase activity
    		•  2.66515798949431 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  2.39333807060713 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  1.99491617326192 bayes_pls_golite062009
  • binding
    		•  1.85951177140712 bayes_pls_golite062009
  • transferase activity
    		•  1.77218599619559 bayes_pls_golite062009
  • protein binding
    		•  1.4657010373022 bayes_pls_golite062009
  • catalytic activity
    		•  0.2012862421225 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle