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Protein Overview: HAP5

General Information:
Name(s) found: HAP5 / YOR358W [SGD]
Description(s) found:
Found 32 descriptions.
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  • Subunit of the heme-activated, glucose-repressed Hap2/3/4/5 CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; required for assembly and DNA binding activity of the complex [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 242 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ICLink to PubMed article]
    CCAAT-binding factor complex [TASLink to PubMed article]
    Biological Process: regulation of carbohydrate metabolic process [TASLink to PubMed article]
    transcription [TASLink to PubMed article]
    Molecular Function: DNA binding [IPILink to PubMed article]
    transcription activator activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTDRNFSPQQ GQGPQESLPE GPQPSTMIQR EEMNMPRQYS EQQQLQENEG EGENTRLPVS  60
   61 EEEFRMVQEL QAIQAGHDQA NLPPSGRGSL EGEDNGNSDG ADGEMDEDDE EYDVFRNVGQ 120
  121 GLVGHYKEIM IRYWQELINE IESTNEPGSE HQDDFKSHSL PFARIRKVMK TDEDVKMISA 180
  181 EAPIIFAKAC EIFITELTMR AWCVAERNKR RTLQKADIAE ALQKSDMFDF LIDVVPRRPL 240
  241 PQ

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) HAP2 HAP3 HAP5
    View Details (MIPS) Mewes HW, et al. (2004) HAP2 HAP3 HAP4 HAP5
    View Details Krogan NJ, et al. (2006) HAP2 HAP3 HAP5
    View Details Gavin AC, et al. (2002) HAP2 HAP3 HAP5
    View Details Ho Y, et al. (2002) AAC3 ARP4 ASA1 ATG17 ATG29 ATP3 CDC33 CIC1 CIS1 CYS4 FOL2 GRH1 HAP2 HAP5 IPP1 LOC1 MAM33 MTQ1 NAP1 NMD5 NOP16 NSA2 POL5 PSE1 RHR2 SAH1 SAP190 SPE3 SSK2 TIF1, TIF2 TIF6 YRA1 YRA2 YTM1
    View Details Qiu et al. (2008) HAP2 HAP3 HAP4 HAP5 TFB5

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen CIA1 HAP5 2 Hazbun TR, et al. (2003)
    View Screen NSE3 HAP5 2 Hazbun TR, et al. (2003)
    View Screen PSF3 HAP5 2 Hazbun TR, et al. (2003)

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data HAP5 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..142] MSA 1.231994 View MSA. No confident structure predictions are available.
    2 View Details [143..242] PSI-BLAST 311.67837 Nuclear transcription factor Y subunit gamma (Nf-Yc2)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • DNA binding
    		•  4.24625687315724 bayes_pls_golite062009
  • transcription regulator activity
    		•  4.08606081850613 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.93473976418251 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  3.89663803383145 bayes_pls_golite062009
  • binding
    		•  3.84636641231951 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.38228606466152 bayes_pls_golite062009
  • transcription factor activity
    		•  2.31114764804139 bayes_pls_golite062009
  • transcription activator activity
    		•  1.25487495162413 bayes_pls_golite062009
  • transcription factor binding
    		•  1.15204005455906 bayes_pls_golite062009
  • transcription coactivator activity
    		•  1.1297723528047 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.01502031330902 bayes_pls_golite062009
  • protein binding
    		•  0.978906971260821 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.72554769377984 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle