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Protein Overview: MRS6

General Information:
Name(s) found: MRS6 / YOR370C [SGD]
Description(s) found:
Found 28 descriptions.
SHOW ALL
  • Rab escort protein, forms a complex with the Ras-like small GTPase Ypt1p that is required for the prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p); sequence similarity to mammalian choroideraemia gene [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 603 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    membrane [IDALink to PubMed article]
    Biological Process: intracellular protein transport [TASLink to PubMed article]
    Molecular Function: GTPase activator activity [IEA]
    Rab GTPase binding [TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLSPERRPSM AERRPSFFSF TQNPSPLVVP HLAGIEDPLP ATTPDKVDVL IAGTGMVESV  60
   61 LAAALAWQGS NVLHIDKNDY YGDTSATLTV DQIKRWVNEV NEGSVSCYKN AKLYVSTLIG 120
  121 SGKYSSRDFG IDLSPKILFA KSDLLSILIK SRVHQYLEFQ SLSNFHTYEN DCFEKLTNTK 180
  181 QEIFTDQNLP LMTKRNLMKF IKFVLNWEAQ TEIWQPYAER TMSDFLGEKF KLEKPQVFEL 240
  241 IFSIGLCYDL NVKVPEALQR IRRYLTSFDV YGPFPALCSK YGGPGELSQG FCRSAAVGGA 300
  301 TYKLNEKLVS FNPTTKVATF QDGSKVEVSE KVIISPTQAP KDSKHVPQQQ YQVHRLTCIV 360
  361 ENPCTEWFNE GESAAMVVFP PGSLKSGNKE VVQAFILGAG SEICPEGTIV WYLSTTEQGP 420
  421 RAEMDIDAAL EAMEMALLRE SSSGLENDEE IVQLTGNGHT IVNSVKLGQS FKEYVPRERL 480
  481 QFLFKLYYTQ YTSTPPFGVV NSSFFDVNQD LEKKYIPGAS DNGVIYTTMP SAEISYDEVV 540
  541 TAAKVLYEKI VGSDDDFFDL DFEDEDEIQA SGVANAEQFE NAIDDDDDVN MEGSGEFVGE 600
  601 MEI

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) GDI1 MRS6 VPS21
    View Details (MIPS) Mewes HW, et al. (2004) BET2 BET4 MRS6
    View Details Krogan NJ, et al. (2006) GDI1 IDP3 MRS6 VPS21 YPT6
    View Details Gavin AC, et al. (2006) MRS6 PYK2
    View Details Ho Y, et al. (2002) BCY1 CDC33 DSS4 GDI1 JJJ1 LAS1 MRS6 POR1 SEC4 SFP1 TPK1 TPK3 TPS1 VPS21 YPT1 YPT10 YPT52 YPT53

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen SPO21 MRS6 2 Unpublished Fields Lab Data
    View Screen NUP1 MRS6 2 Unpublished Fields Lab Data
    View Screen YPT31 MRS6 2 Unpublished Fields Lab Data
    View Screen BOI2 MRS6 2 Drees BL, et al. (2001)
    View Screen SEC4 MRS6 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data MRS6 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..494] PSI-BLAST 418.228787 Guanine nucleotide dissosiation inhibitor, GDI
    2 View Details [495..603] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • small GTPase regulator activity
    		•  1.82777033221452 bayes_pls_golite062009
  • binding
    		•  1.71679209220564 bayes_pls_golite062009
  • GTPase regulator activity
    		•  1.69589677829425 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  1.67690582043816 bayes_pls_golite062009
  • transporter activity
    		•  1.29839290134235 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.27958088282173 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.26584665095879 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.07862908893913 bayes_pls_golite062009
  • catalytic activity
    		•  1.03127962968326 bayes_pls_golite062009
  • DNA binding
    		•  1.02814395937345 bayes_pls_golite062009
  • enzyme regulator activity
    		•  1.00883251592654 bayes_pls_golite062009
  • amine oxidase activity
    		•  0.93095855430028 bayes_pls_golite062009
  • transcription factor activity
    		•  0.569299976584703 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.556967966402473 bayes_pls_golite062009
  • GDP-dissociation inhibitor activity
    		•  0.387378304822822 bayes_pls_golite062009
  • protein binding
    		•  0.347133050347128 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.31459693204333 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.92

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle