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Protein Overview: IRC15

General Information:
Name(s) found: IRC15 / YPL017C [SGD]
Description(s) found:
Found 28 descriptions.
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  • Microtubule associated protein; regulates microtubule dynamics; required for accurate meiotic chromosome segregation; null mutant displays large budded cells due to delayed mitotic progression, increased levels of spontaneous Rad52 foci [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 499 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: biological_process [ND]
    Molecular Function: S-adenosylmethionine-dependent methyltransferase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGGEDEILST MEDFAAVYDV LVIGCGPGGF TAAMQASQAG LLTACVDQRA SLGGAYLVDG  60
   61 AVPSKTLLYE SYLYRLLQQQ ELIEQRGTRL FPAKFDMQAA QSALKHNIEE LGNVYKRELS 120
  121 KNNVTVYKGT AAFKDPHHVE IAQRGMKPFI VEAKYIVVAT GSAVIQCPGV AIDNDKIISS 180
  181 DKALSLDYIP SRFTIMGGGT IGLEIACIFN NLGSRVTIVE SQSEICQNMD NELASATKTL 240
  241 LQCQGIAFLL DTRVQLAEAD AAGQLNITLL NKVSKKTYVH HCDVLMVSIG RRPLLKGLDI 300
  301 SSIGLDERDF VENVDVQTQS LLKYPHIKPI GDVTLGPMLA LKAEEQAIRA IQSIGCTGSD 360
  361 GTSNCGFPPN VLYCQPQIGW VGYTEEGLAK ARIPYQKGRV LFSQNVRYNT LLPREENTTV 420
  421 SPFIKVLIDS RDMKILGVHM INDDANELLS QASMAVSLGL TAHDVCKVPF PHPSLSESFK 480
  481 QAVQLAMANG TSPGVHVRE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen HSH49 IRC15 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data IRC15 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..59]
    [109..163]
    [292..365]    		 PSI-BLAST 989.0103 Dihydrolipoamide dehydrogenase
    2 View Details [60..108]
    [164..291]
    [366..371]    		 PSI-BLAST 989.0103 Dihydrolipoamide dehydrogenase
    3 View Details [372..499] PSI-BLAST 989.0103 Dihydrolipoamide dehydrogenase


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.74

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle