YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: IQG1

General Information:
Name(s) found: IQG1 / YPL242C [SGD]
Description(s) found:
Found 28 descriptions.
SHOW ALL
  • Essential protein required for determination of budding pattern, promotes localization of axial markers Bud4p and Cdc12p and functionally interacts with Sec3p, localizes to the contractile ring during anaphase, member of the IQGAP family [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1495 amino acids

    Gene Ontology:
    Cellular Component: cellular bud neck contractile ring [IDALink to PubMed article]
    Biological Process: response to osmotic stress [IMPLink to PubMed article]
    cytokinesis [IMPLink to PubMed article]
    actin filament organization [IPILink to PubMed article]
    Molecular Function: cytoskeletal protein binding [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTAYSGSPSK PGNNNSYLNR YVENLGTNVT PPLRPQSSSK INSSLNIASP SHLKTKTSAS  60
   61 NSSATILSKK VESSVSKLKP SLPNKLVGKY TVDLSNYSKI ELRYYEFLCR VSEVKIWIEA 120
  121 VIEEALPSEI ELCVGDSLRN GVFLAKLTQR INPDLTTVIF PAGDKLQFKH TQNINAFFGL 180
  181 VEHVGVPDSF RFELQDLYNK KNIPQVFETL HILISMINKK WPGKTPALTN VSGQISFTKE 240
  241 EIAACKKAWP RIRDFKSLGT NINTAPASPE EPKEKRSGLI KDFNKFERPN IPVEEILITP 300
  301 RKNITDANCS DFSNTPSPYN EAPKMSNLDV VVEKRKFTPI EPSLLGPTPS LEYSPIKNKS 360
  361 LSYYSPTISK YLTYDTEFYT RRSRAREEDL NYYQTFKYSP SHYSPMRRER MTEEQFLEKV 420
  421 VQLQNICRGV NTRFNLYIQK RLLNLFEQDI LRFQACLRGN KFRVLSSMYL PIRRAKIDVP 480
  481 HVEAIQSRIK GSRIRYKYDK LKFTLSRFSC TVELLQAYCR SKLLKTTVNT KLNDIEISHY 540
  541 PLTKLQSYMR ASYVRKKVMS LNTKLNDERE SIMKFSAIIR GNVVRCSEDA ILSAVHDVHK 600
  601 ENISKLQSLI RGIFTRSCLA SIIYSLGKEN CNIIQLSACI RGNAVRHKVQ SLFAPENNLS 660
  661 ETVHDLQGLV RGILVRYTLD LVDDIVEYNN LALFQAFSRG ALVRESLDQK SSFYKRNVRS 720
  721 VIMIQSWIRK SLQRSAYLEL LDCPNPSLWA VKKFVHLLNG TATIEEVQNQ LESCQASLDS 780
  781 ENMKKERLLK SIRQQLNING VLDKFGLLKD KDHELGISDS TIPKSKYQKY EKLFYMLQVD 840
  841 PSYWKLLYLK EPEFVAKNVY MTFGTVNQRM NDRERSYFTR FVCEMLQNAI NEAPSIESFL 900
  901 DNRSQFWQTI LQDFLRRESP EFFSIIVPVL DYLSDPVVDF ESDPYKIYQE IHGFSSPQHC 960
  961 SPVDDASTKN KFIDNLRCLW HAIEMVAEIY TRKVHTIPVE IRYLCTKIFC YAADKNIEEI1020
 1021 DSLRAISSIL VNVFVSEYLV NREYYGYKDS NVQKNNQKID ILMKSLATVF EIKNFDGFLD1080
 1081 PLNQYANEIK PHIKDVLYNV LVDPEYEQEG DRLIYLDMVS PSPKLELLTE KVLEISGKFE1140
 1141 EYLNEFPEAD ILHDILEKNL DNSSFPRSGR VTLELDASAY RFLVSDDKMR KIYDQVKRAF1200
 1201 VYMMQIEDVD TNLYDLSIST ILPQDEPNFA NFLEQNPKIR DDPMIQKLKP LKYFTLKNVT1260
 1261 LKKIHELEST GTFCSSDNKL QNFLNDIANT IKNPNYAIDY VTQEIYITKE TLTKISEMNH1320
 1321 SLDIELSRLK KHVDHTIKDF QKAKDFSPVH KSKFGNFKNA VKKVQGRERS ELQGMKFKWN1380
 1381 TKQLYERGVL KTIRGEKLAE LTVKVFGSSG PKFPDIIFKI STSDGSRFGI QMIDKRKGPD1440
 1441 KRYSDDVDSF SFKDLIKTQV EPKIETWKLF HSNVVVNNSQ LLHLIVSFFY KRNAL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) CSI1 CSN9 ERV46 FPR2 HUL5 IQG1 MOT1 MPT5 NAS6 NMD3 NPT1 PCI8 PEP1 PST1 PUS9 RPN1 RPN10 RPN11 RPN12 RPN13 RPN14 RPN2 RPN5 RPN6 RPN7 RPN8 RPN9 RPT1 RPT2 RPT3 RPT4 RPT5 RPT6 RRI1 RRI2 SEC18 SEM1 SKP1 SPG5 SPO77 SQT1 SWA2 TCB2 TIP41 TOD6 TOR2 TSR4 UBP6 YEN1 YKL027W YMR258C YNL022C YPR003C YPT52
    View Details Qiu et al. (2008) ABP1 AIP1 ARP2 BNI1 BNR1 BOI2 BUD6 CDC11 CDC12 CDC3 ELM1 HOF1 HSK3 IQG1 LAS17 MLC2 PAN1 PEA2 PFY1 RVS161 RVS167 SCP1 SLA1 SLA2 SPA2 SPH1 STU2 TPM1 TPM2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #21 Asynchronous Prep2-IMAC Phosphopeptide enrichment A1 Keck JM, et al. (2011)
    View Run MLP2 #34 Asynchronous SPB prep Keck JM, et al. (2011)
    View Run MLP2 #14 Mitotic Prep2-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #13 Mitotic Prep2-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen MLC1 IQG1 2 Unpublished Fields Lab Data
    View Screen PRP16 IQG1 2 Unpublished Fields Lab Data
    View Screen IQG1 FUS1 2 Unpublished Fields Lab Data
    View Screen IQG1 ENT4 2 Unpublished Fields Lab Data
    View Screen IQG1 YLR428C 2 Unpublished Fields Lab Data
    View Screen IQG1 YNL146W 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data IQG1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..86] deduced N/A No confident structure predictions are available.
    2 View Details [87..675] PSI-BLAST 149.0 Heavy meromyosin subfragment
    3 View Details [676..973] PSI-BLAST 149.0 Heavy meromyosin subfragment
    4 View Details [974..1168] PSI-BLAST 57.0 GAP related domain of neurofibromin
    5 View Details [1169..1249] deduced N/A No confident structure predictions are available.
    6 View Details [1250..1495] MSA 2.024962 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6
    Term Confidence Notes
  • actin binding
    		•  4.78749876353566 bayes_pls_golite062009
  • GTPase regulator activity
    		•  3.48313315541019 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  3.46216378778416 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  3.44145669357816 bayes_pls_golite062009
  • enzyme regulator activity
    		•  2.73117303901364 bayes_pls_golite062009
  • calmodulin binding
    		•  2.44376064579262 bayes_pls_golite062009
  • binding
    		•  2.21550924222852 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  1.52776228366828 bayes_pls_golite062009
  • protein binding
    		•  1.37785152807615 bayes_pls_golite062009
  • Ras GTPase activator activity
    		•  1.32591250158464 bayes_pls_golite062009
  • GTPase inhibitor activity
    		•  1.1177126331255 bayes_pls_golite062009
  • Rho GTPase binding
    		•  1.00104187823298 bayes_pls_golite062009
  • GTPase activator activity
    		•  0.945543525650563 bayes_pls_golite062009
  • small GTPase binding
    		•  0.78616895231719 bayes_pls_golite062009
  • GTPase binding
    		•  0.76727022636058 bayes_pls_golite062009
  • enzyme activator activity
    		•  0.514378360493585 bayes_pls_golite062009
  • enzyme binding
    		•  0.44096806806257 bayes_pls_golite062009
  • Ras GTPase binding
    		•  0.245740027562592 bayes_pls_golite062009
  • enzyme inhibitor activity
    		•  0.0914865633301911 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle