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Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, and no oxidized product appears. Catalysis of the reaction: (5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-6,9-alpha-epoxy-11-alpha,15-dihydroxyprosta-5,13-dienoate. Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: prostaglandin-I synthase activity
Acc: GO:0008116
Aspect: Molecular Function
Desc: Catalysis of the reaction: (5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-6,9-alpha-epoxy-11-alpha,15-dihydroxyprosta-5,13-dienoate.
Synonyms:
  • prostacycline synthetase activity
  • PGI2 synthetase activity
  • prostagladin I2 synthetase activity
  • PGI2 synthase activity
  • cytochrome P450 CYP8A1
  • PGI(2) synthetase activity
  • prostacyclin synthase activity
  • (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate 6-isomerase activity
  • PGI(2) synthase activity
Proteins in PDR annotated with:
   This term: 1 [Search]
   Term or descendants: 1 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0008116 - prostaglandin-I synthase activity (interactive image map)
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Created and Maintained by: Michael Riffle