YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|157832060, gi...
Organism:	Escherichia coli
Length:	225 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|157832060, gi....

Description	E-value	Query Range	Subject Range
gi\|75819192, gi\|... - gi\|75819192\|ref\|ZP_00749285.1\| COG1194: A/G-specific DNA glycosylase [Vibrio cholerae V51], gi\|11621...	276.0	[0..3]	[225..17]
gi\|116189574, gi... - gi\|75829107\|ref\|ZP_00758424.1\| COG1194: A/G-specific DNA glycosylase [Vibrio cholerae MO10], gi\|1161...	274.0	[0..3]	[225..17]
gi\|238795061, gi... - gi\|77976485\|ref\|ZP_00831971.1\| COG1194: A/G-specific DNA glycosylase [Yersinia intermedia ATCC 29909...	274.0	[0..1]	[225..19]
gi\|75822032, gi\|... - gi\|75822032\|ref\|ZP_00751746.1\| COG1194: A/G-specific DNA glycosylase [Vibrio cholerae RC385], gi\|116...	273.0	[0..3]	[225..17]
Q666M4\|Q666M4_YERPS - A/G-specific adenine glycosylase. - Yersinia pseudotuberculosis gi\|51590816, gi\|... - gi\|51597534\|ref\|YP_071725.1\| adenine DNA glycosylase [Yersinia pseudotuberculosis IP 32953], gi\|5159...	273.0	[0..1]	[225..1]
gi\|152958814, gi... - gi\|77630200\|ref\|ZP_00792786.1\| COG1194: A/G-specific DNA glycosylase [Yersinia pseudotuberculosis IP...	272.0	[0..1]	[225..1]
gi\|77959941 - gi\|77959941\|ref\|ZP_00823854.1\| COG1194: A/G-specific DNA glycosylase [Yersinia mollaretii ATCC 43969...	272.0	[0..1]	[225..21]
gi\|68546031, gi\|... - gi\|68546031\|ref\|ZP_00585580.1\| A/G-specific adenine glycosylase MutY [Shewanella amazonensis SB2B], ...	272.0	[0..5]	[225..211]
gi\|227008550, gi... - gi\|227080662\|ref\|YP_002809213.1\| A/G-specific adenine glycosylase [Vibrio cholerae M66-2], gi\|227008... gi\|121728580, gi... - gi\|121728580\|ref\|ZP_01681601.1\| A/G-specific adenine glycosylase [Vibrio cholerae V52], gi\|121629136... gi\|15640479, gi\|... - gi\|9654877\|gb\|AAF93625.1\| A/G-specific adenine glycosylase [Vibrio cholerae O1 biovar El Tor str. N1... gi\|11354352 - pir\|\|D82320 A/G-specific adenine glycosylase VC0452 [imported] - Vibrio cholerae (strain N16961 sero... gi\|125618186 - gi\|125618186\|gb\|EAZ46730.1\| A/G-specific adenine glycosylase [Vibrio cholerae MO10] gi\|153224226, gi... - gi\|153224226\|ref\|ZP_01954309.1\| A/G-specific adenine glycosylase [Vibrio cholerae MAK 757], gi\|12411... gi\|153823186, gi... - gi\|153823186\|ref\|ZP_01975853.1\| A/G-specific adenine glycosylase [Vibrio cholerae B33], gi\|126519312... gi\|153819148, gi... - gi\|153819148\|ref\|ZP_01971815.1\| A/G-specific adenine glycosylase [Vibrio cholerae NCTC 8457], gi\|126...	272.0	[0..1]	[225..1]
gi\|77956385 - gi\|77956385\|ref\|ZP_00820488.1\| COG1194: A/G-specific DNA glycosylase [Yersinia bercovieri ATCC 43970...	271.0	[0..1]	[225..2]

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Predicted Domain #1

Region A:
Residues: [1-225]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQASQFSAQV LDWYDKYGRK TLPWQIDKTP YKVWLSEVML QQTQVATVIP YFERFMARFP  60
   61 TVTDLANAPL DEVLHLWTGL GYYARARNLH KAAQQVATLH GGKFPETFEE VAALPGVGRS 120
  121 TAGAILSLSL GKHFPILNGN VKRVLARCYA VSGWPGKKEV ENKLWSLSEQ VTPAVGVERF 180
  181 NQAMMDLGAM ICTRSKPKCS LCPLQNGCIA AANNSWALYP GKKPK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	72.221849
Match:	1kg5A
Description:	Catalytic domain of MutY
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
DNA N-glycosylase activity	4.8124964619976	bayes_pls_golite062009
hydrolase activity, hydrolyzing N-glycosyl compounds	4.26870112679392	bayes_pls_golite062009
DNA-(apurinic or apyrimidinic site) lyase activity	3.71152530486175	bayes_pls_golite062009
oxidized base lesion DNA N-glycosylase activity	2.49872706126491	bayes_pls_golite062009
hydrolase activity	2.39042189031819	bayes_pls_golite062009
8-oxo-7,8-dihydroguanine DNA N-glycosylase activity	2.21048599823382	bayes_pls_golite062009
hydrolase activity, acting on glycosyl bonds	2.18053745735048	bayes_pls_golite062009
catalytic activity	2.13345932727422	bayes_pls_golite062009
damaged DNA binding	2.00388798014411	bayes_pls_golite062009
alkylbase DNA N-glycosylase activity	1.5832578018127	bayes_pls_golite062009
DNA binding	1.44394874535958	bayes_pls_golite062009
nucleic acid binding	1.36800347239439	bayes_pls_golite062009
oxidized purine base lesion DNA N-glycosylase activity	1.32985950765371	bayes_pls_golite062009
oxidized pyrimidine base lesion DNA N-glycosylase activity	1.2016453685638	bayes_pls_golite062009
binding	1.15752946565805	bayes_pls_golite062009
DNA-3-methyladenine glycosylase I activity	1.06383943982125	bayes_pls_golite062009
uracil DNA N-glycosylase activity	0.879508131574476	bayes_pls_golite062009
structure-specific DNA binding	0.85419760398899	bayes_pls_golite062009
purine-specific mismatch base pair DNA N-glycosylase activity	0.68578837518217	bayes_pls_golite062009
mismatch base pair DNA N-glycosylase activity	0.661651574677137	bayes_pls_golite062009
double-stranded DNA binding	0.57099109384393	bayes_pls_golite062009
transcription regulator activity	0.493252955870142	bayes_pls_golite062009
protein binding	0.0921713980805489	bayes_pls_golite062009
carbon-oxygen lyase activity	0.0676784802238829	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: