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View Structure Prediction Details

Protein: gi|20150246, gi|...
Organism: Rattus norvegicus
Length: 230 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|20150246, gi|....

Description E-value Query
Range
Subject
Range
gi|255061 - gi|255061|gb|AAB23164.1| GTP cyclohydrolase I [Homo sapiens]
316.0 [0..1] [230..12]
gi|109083691 - gi|109083691|ref|XP_001087365.1| PREDICTED: GTP cyclohydrolase 1 (dopa-responsive dystonia) isoform ...
312.0 [0..1] [230..21]
GCH1_RAT - GTP cyclohydrolase 1 OS=Rattus norvegicus GN=Gch1 PE=1 SV=1
311.0 [0..1] [230..12]
GCH1_MOUSE - GTP cyclohydrolase 1 OS=Mus musculus GN=Gch1 PE=1 SV=1
307.0 [0..1] [230..12]
gi|73963003 - gi|73963003|ref|XP_851883.1| PREDICTED: similar to GTP cyclohydrolase I (GTP-CH-I) isoform 1 [Canis ...
302.0 [0..3] [230..5]
gi|49645805, gi|... - gi|50543548|ref|XP_499940.1| hypothetical protein [Yarrowia lipolytica], gi|49645805|emb|CAG83867.1|...
295.0 [0..1] [228..72]
gi|68354410, gi|... - gi|68354410|ref|XP_694873.1| PREDICTED: similar to GTP cyclohydrolase I precursor (GTP-CH-I) [Danio ...
292.0 [0..10] [230..31]

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Predicted Domain #1
Region A:
Residues: [1-230]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GFPERELPRP GASRPAEKSR PPEAKGAQPA DAWKAGRPRS EEDNELNLPN LAAAYSSILR  60
   61 SLGEDPQRQG LLKTPWRAAT AMQFFTKGYQ ETISDVLNDA IFDEDHDEMV IVKDIDMFSM 120
  121 CEHHLVPFVG RVHIGYLPNK QVLGLSKLAR IVEIYSRRLQ VQERLTKQIA VAITEALQPA 180
  181 GVGVVIEATH MCMVMRGVQK MNSKTVTSTM LGVFREDPKT REEFLTLIRS 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 85.154902
Match: 1is7A
Description: GTP cyclohydrolase I
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
GTP cyclohydrolase I activity 5.27071565931386 bayes_pls_golite062009
cyclohydrolase activity 3.66553359909123 bayes_pls_golite062009
GTP cyclohydrolase activity 3.44912994722205 bayes_pls_golite062009
6-pyruvoyltetrahydropterin synthase activity 2.94513271787536 bayes_pls_golite062009
catalytic activity 2.20788162511962 bayes_pls_golite062009
dihydroneopterin aldolase activity 1.96466418682643 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 1.73101699306211 bayes_pls_golite062009
binding 1.62520629128577 bayes_pls_golite062009
protein binding 1.34873192832825 bayes_pls_golite062009
hydrolase activity 1.10190985324326 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0.974891318710762 bayes_pls_golite062009
carbon-carbon lyase activity 0.25616855487144 bayes_pls_golite062009
urate oxidase activity 0.0294957696532921 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
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