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View Structure Prediction Details

Protein: CNN2_PONAB
Organism: Pongo abelii
Length: 309 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CNN2_PONAB.

Description E-value Query
Range
Subject
Range
gi|114630314 - gi|114630314|ref|XP_001156976.1| PREDICTED: similar to neutral calponin isoform 2 [Pan troglodytes]
0.0 [1..309] [1..309]
gi|60818291 - gi|60818291|gb|AAX36458.1| calponin 2 [synthetic construct]
gi|187950321, gi... - gi|49456577|emb|CAG46609.1| CNN2 [Homo sapiens], gi|187950321|gb|AAI48265.1| Calponin 2 [Homo sapien...
0.0 [1..309] [1..309]
gi|109075217, gi... - gi|109075217|ref|XP_001110816.1| PREDICTED: similar to calponin 2 isoform a isoform 4 [Macaca mulatt...
0.0 [1..309] [1..309]
CNN2_MOUSE - Calponin-2 OS=Mus musculus GN=Cnn2 PE=1 SV=1
0.0 [1..309] [1..305]
gi|60826805 - gi|60826805|gb|AAX36772.1| calponin 3 [synthetic construct]
0.0 [4..306] [2..311]

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Predicted Domain #1
Region A:
Residues: [1-159]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSTQFNKGP SYGLSAEVKN RLLSKYDPQK EAELRTWIEG LTGLSIGPDF QKGLKDGTIL  60
   61 CTLMNKLQPG SVPKINRSMQ NWHQLENLSN FIKAMVSYGM NPVDLFEAND LFESGNMTQV 120
  121 QVSLLALAGK AKTKGLQSGV DIGVKYSEKQ ERNFDDATM

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 42.221849
Match: 1wynA
Description: Solution structure of the CH domain of human calponin-2
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [160-240]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KAGQCVIGLQ MGTNKCASQS GMTAYGTRRH LYDPKNHILP PMDHSTISLQ MGTNKCASQV  60
   61 GMTAPGTRRH IYDTKLGTDK C

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 7.522879
Match: 1ujyA
Description: Solution structure of SH3 domain in Rac/Cdc42 guanine nucleotide exchange factor(GEF) 6
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
actin binding 4.94949685871786 bayes_pls_golite062009
structural constituent of muscle 4.65743655357495 bayes_pls_golite062009
cytoskeletal protein binding 4.41722924924158 bayes_pls_golite062009
actin filament binding 3.69427077755816 bayes_pls_golite062009
binding 3.06905798270146 bayes_pls_golite062009
protein binding 2.08632303609243 bayes_pls_golite062009
signal transducer activity 1.34867629228264 bayes_pls_golite062009
molecular transducer activity 1.34867629228264 bayes_pls_golite062009
vinculin binding 1.06656350652527 bayes_pls_golite062009
transporter activity 0.896907103596953 bayes_pls_golite062009
transmembrane transporter activity 0.713068405985864 bayes_pls_golite062009
substrate-specific transporter activity 0.500685400112742 bayes_pls_golite062009
structural constituent of cytoskeleton 0.371928447183203 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.272368655500689 bayes_pls_golite062009
ion transmembrane transporter activity 0.00318812576030902 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [241-309]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DNSSMSLQMG YTQGANQSGQ VFGLGRQIYD PKYCPQGTVA DGAPSGTGDC PDPGEVPEYP  60
   61 PYYQEEAGY

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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