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View Structure Prediction Details

Protein: ec-PA
Organism: Drosophila melanogaster
Length: 1712 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ec-PA.

Description E-value Query
Range
Subject
Range
ec-PB - The gene echinus is referred to in FlyBase by the symbol Dmel\ec (CG2904, FBgn0000542). It is a prot...
1240.0 [0..31] [1712..64]

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Predicted Domain #1
Region A:
Residues: [1-415]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDTAAIKTSL PHAPLAGQQQ PQQAQTTTAM AVAPTTITNA QTSAINAKNN IGAFFQTCKV  60
   61 LWHLDAFRRS FRGLNQHVCG GQDCIFCALK ELFQQLQTSS EPALCPEPLR RALASGPLAG 120
  121 RRFPLGCLGD AAECFELLLH RVHSHISPDD GDSCESSACI AHRRFAMRVI EQSVCKCGAN 180
  181 SEQLPFTQMV HYVSASALTS QKSLALQSHQ QLSFGQLLRA AGNMGDIRDC PNTCGAKIGI 240
  241 CRALLNRPEV VSIGIVWDSE RPAADQVHAV LKAVGTSLRL GDVFHQVSEP RWAQQTQHEL 300
  301 VGIVSYYGKH YTTFFFHTKL KVWVYFDDAN VKEVGPSWEG VVDKCSRGRY QPLLLLYAVP 360
  361 QQPTVGNGVG IGHVDVAMPA SAPSIAGSVV RRAVTPSPEK PSLGNTRRAI TPTPL

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 3.1
Match: 1nb8A
Description: Ubiquitin carboxyl-terminal hydrolase 7 (USP7, HAUSP)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cysteine-type peptidase activity 0.560349219089937 bayes_pls_golite062009
binding 0.1527582694371 bayes_pls_golite062009
protein binding 0.139172653049021 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [416-587]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RTPPNDYQNL SVIQKNIFPS NLAMGTDETD AYISRKTVEH VLSAQYQNLS VIQDKIGGGN  60
   61 GVGVGQQSVD KDGGFLSRKP IEAVLSAQLA RRQHLQLQRS HSAESSSGHA SSNGSSPPSD 120
  121 GLTMPEHLNQ PRRRDSGNWS GDRNSASSAS STTLDNPYLY MVAKRGVAAV PQ

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [588-777]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPTRHGLPYD PGYDSFSLSS TDSYPPKHAL NPQLAKIPEA AMGVVPNGGA MPHGHGNGQL  60
   61 ALSGDCEKLC HEADQLLEKS RLVEESHDLE TALVLCNAAA GRARAAMDAP YSNPHTMTFA 120
  121 RMKHNTCVMR ARSLHRRILV EKGAETEAMP ELKHMREGST SSVKHVRQNS KDRTLEKEQQ 180
  181 QLQFQQIQQI 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [778-962]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QQIHQIQQQI PASIEIYATL PKRKSPLKAL ASASACDDNA IEYEQEKQLA TSPGKPERES  60
   61 RSLFGRKDKE KEKRSRSEDR NKLTREFSLT ETLLVNAKDT LKKHKEDKDE KKEKDKSGKK 120
  121 QHKIRRKLLM GGLIRRKNRS MPDLTEAVDD STANAGITHH PHYPAQGVTT AGTLLGTSVD 180
  181 DSAVG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [963-1048]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LGKHGHGMSG YISEGHFDYS GSGSASNSGA GSNPNPNLER SKLMRKSFHG SGRQLTMVPK  60
   61 VAPPPPMRTS STLTPQQQQQ QQQQFH

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [1049-1402]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HEANLSNLSA MSSNTSISED SCQTIITTCA QVHSEQSPLK DLQMLVAQDE LPLPPPMELP  60
   61 PYPSPPHSSC HSRQASEDFP PPPPPELDLE PLNQQLSQLQ ALEAASKQQR QQLESLEGTT 120
  121 SILAQLQQRQ HLLKLRKEQA NHPGAATTDA TWLKELQAKQ ANDLRAMQRK LEASSPSSVR 180
  181 DLTHRFEQTS IRSYASQELL SQPGQSQQLG QLRTQMNGLP NGNAKMDVDE VDAMPAVRNS 240
  241 LPAALSAHQL LPKPKYEMTQ SQIAEEIREV ELLNTMVQQT LNQNGAAALP KRVKKKSVSF 300
  301 CDQVILVATA GNEEDDDFIP NPILERVLRT AQHPNEKVTA QMIQQQQQNM MRLQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 17.221849
Match: 1i84S
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #7
Region A:
Residues: [1403-1712]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TEAQPRQQQV QQLQQPSPML GRPAGATADM QRYVQRMQQQ QQQQQQQQQQ QQQQQQQQQQ  60
   61 QQQQQQQQQQ QHQELYRQQQ LHRTSMSGIA SQQHLQQLDA QYTTMPRPLH HSQLGSYSVT 120
  121 LQKHQQLQQQ QQQQQQQQAP QQLSLGYFSN GSVATSEQVP LPSPYQRVPL PHGYQPAAAG 180
  181 PYYPLPNAQQ HLQQQQLMAK PVQKKVSFEP GTKGEADCLP PPPPPPQKNG LPETGSAGSG 240
  241 HPGAAPGASG AGGTTSAGIT AIPTRVYNNA IVKASAKAVE CNLCRKRHVI APAVYCTNCE 300
  301 YYLQMLNQRR 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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