YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|166961867, gi...
Organism:	Yersinia pestis biovar Orientalis str. MG05-1020
Length:	891 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|166961867, gi....

Description	E-value	Query Range	Subject Range
gi\|229681001, gi... - gi\|229902105\|ref\|ZP_04517226.1\| multifunctional acetaldehyde-CoA dehydrogenase and iron-dependent al... gi\|167424931, gi... - gi\|167424931\|ref\|ZP_02316684.1\| aldehyde-alcohol dehydrogenase [Yersinia pestis biovar Mediaevalis s... gi\|22125915, gi\|... - gi\|22125915\|ref\|NP_669338.1\| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Yersinia pestis KI...	0.0	[1..891]	[1..891]
gi\|36785819, gi\|... - gi\|37526388\|ref\|NP_929732.1\| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Photorhabdus lumin...	0.0	[8..875]	[8..875]
gi\|238718764, gi... - gi\|77960743\|ref\|ZP_00824601.1\| COG1012: NAD-dependent aldehyde dehydrogenases [Yersinia mollaretii A...	0.0	[1..875]	[1..875]
gi\|238723361, gi... - gi\|77972680\|ref\|ZP_00828240.1\| COG1012: NAD-dependent aldehyde dehydrogenases [Yersinia frederikseni...	0.0	[1..873]	[1..873]
gi\|238794920, gi... - gi\|77977790\|ref\|ZP_00833230.1\| COG1012: NAD-dependent aldehyde dehydrogenases [Yersinia intermedia A...	0.0	[1..875]	[1..875]
gi\|85059350, gi\|... - gi\|85059350\|ref\|YP_455052.1\| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Sodalis glossinidi...	0.0	[1..891]	[1..902]
gi\|238713574, gi... - gi\|77957075\|ref\|ZP_00821141.1\| COG1012: NAD-dependent aldehyde dehydrogenases [Yersinia bercovieri A...	0.0	[1..872]	[1..872]
gi\|62127947, gi\|... - gi\|62180314\|ref\|YP_216731.1\| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Salmonella enteric...	0.0	[1..891]	[1..890]
gi\|49611780, gi\|... - gi\|50121254\|ref\|YP_050421.1\| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Pectobacterium atr...	0.0	[1..874]	[1..874]
gi\|75190291, gi\|... - gi\|75190291\|ref\|ZP_00703558.1\| COG1012: NAD-dependent aldehyde dehydrogenases [Escherichia coli E243...	0.0	[1..872]	[1..872]

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Predicted Domain #1

Region A:
Residues: [1-447]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAVTNVAELN ELVARVKKAQ REYANFSQEQ VDKIFRAAAL AAADARIPLA KLAVTESGMG  60
   61 IVEDKVIKNH FASEYIYNAY KDEKTCGILC EDKTFGTITI AEPIGLICGI VPTTNPTSTA 120
  121 IFKALISLKT RNGIIFSPHP RAKDATNKAA DIVLQAAIAA GAPADIIGWI DAPTVELSNQ 180
  181 LMHHPDINLI LATGGPGMVK AAYSSGKPAI GVGAGNTPVV VDETADIKRV VASILMSKTF 240
  241 DNGVICASEQ SIIVVDSVYD AVRERFASHG GYLLQGKELK AVQDIILKNG GLNAAIVGQP 300
  301 ATKIAEMAGI KVPSNTKILI GEVKVVDESE PFAHEKLSPT LAMYRAKNFE EAVEKAEKLV 360
  361 EMGGIGHTSC LYTDQDNQTA RVKYFGDKMK TARILINTPA SQGGIGDLYN FKLAPSLTLG 420
  421 CGSWGGNSIS ENVGPKHLIN KKTVAKR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	135.0
Match:	1bi9A
Description:	Aldehyde reductase (dehydrogenase), ALDH
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
oxidoreductase activity	4.47226217021998	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	4.34495776828926	bayes_pls_golite062009
3-chloroallyl aldehyde dehydrogenase activity	3.37049090049734	bayes_pls_golite062009
succinate-semialdehyde dehydrogenase [NAD(P)+] activity	3.30681232755737	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	3.2867555127991	bayes_pls_golite062009
aldehyde dehydrogenase (NAD) activity	2.81851373615334	bayes_pls_golite062009
catalytic activity	2.80804701752928	bayes_pls_golite062009
succinate-semialdehyde dehydrogenase activity	2.25908515251731	bayes_pls_golite062009
benzaldehyde dehydrogenase activity	1.80313175632526	bayes_pls_golite062009
methylmalonate-semialdehyde dehydrogenase (acylating) activity	1.59279206536309	bayes_pls_golite062009
1-pyrroline-5-carboxylate dehydrogenase activity	1.15620590715864	bayes_pls_golite062009
binding	0.637403449596354	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [448-891]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AENMLWHKLP KSIYFRRGSL PIALEEVATD GAKRAFIVTD RYLFNNGYAD QVTSVLKSHG  60
   61 IETEVFFEVE ADPTLSIVRK GAEQMNSFKP DVIIALGGGS PMDAAKIMWV MYEHPETHFE 120
  121 ELALRFMDIR KRIYKFPKMG VKAKLVAITT TSGTGSEVTP FAVVTDDATG QKYPLADYAL 180
  181 TPDMAIVDAN LVMNMPKSLC AFGGLDAVTH ALEAYVSVLA NEYSDGQALQ ALKLLKEFLP 240
  241 ASYNEGAKNP VARERVHNAA TIAGIAFANA FLGVCHSMAH KLGSEFHIPH GLANAMLISN 300
  301 VIRYNANDNP TKQTAFSQYD RPQARRRYAE IADHLGLSAP GDRTAQKIQK LLAWLDEIKA 360
  361 ELGIPASIRE AGVQEADFLA KVDKLSEDAF DDQCTGANPR YPLISELKQI LMDTYYGREY 420
  421 VEEFDREEEV AAATAPKAEK KTKK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	96.522879
Match:	1rrmA
Description:	Crystal Structure of Lactaldehyde reductase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
hydroxyacid-oxoacid transhydrogenase activity	8.51876704052427	bayes_pls_golite062009
alcohol dehydrogenase (NAD) activity	5.26400058766942	bayes_pls_golite062009
oxidoreductase activity	3.07409531087588	bayes_pls_golite062009
alcohol dehydrogenase activity, metal ion-independent	3.05722501802075	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	2.83823088483915	bayes_pls_golite062009
catalytic activity	2.37357608468991	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	2.10085302216488	bayes_pls_golite062009
binding	1.15096180564234	bayes_pls_golite062009
3-chloroallyl aldehyde dehydrogenase activity	0.831155115586418	bayes_pls_golite062009
cation binding	0.319000821544479	bayes_pls_golite062009
metal ion binding	0.319000821544479	bayes_pls_golite062009
ion binding	0.313606245452103	bayes_pls_golite062009
protein binding	0.295023706645045	bayes_pls_golite062009
transition metal ion binding	0.259889634539407	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	0.0904828025133766	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: