YRC Public Data Repository - Protein Structure Prediction

Protein:	TYSY_ECO8A
Organism:	Escherichia coli IAI1
Length:	264 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TYSY_ECO8A.

Description	E-value	Query Range	Subject Range
gi\|11256673 - pir\|\|G81050 thymidylate synthase NMB1709 [imported] - Neisseria meningitidis (strain MC58 serogroup ... TYSY_NEIMB - Thymidylate synthase OS=Neisseria meningitidis serogroup B (strain MC58) GN=thyA PE=3 SV=1 TYSY_NEIMB - Thymidylate synthase OS=Neisseria meningitidis serogroup B GN=thyA PE=3 SV=1	457.0	[0..1]	[264..1]
gi\|11256672 - pir\|\|A81825 thymidylate synthase (EC 2.1.1.45) NMA1963 [imported] - Neisseria meningitidis (strain Z... TYSY_NEIMA - Thymidylate synthase OS=Neisseria meningitidis serogroup A GN=thyA PE=3 SV=1 TYSY_NEIMA - Thymidylate synthase OS=Neisseria meningitidis serogroup A / serotype 4A (strain Z2491) GN=thyA PE=3...	457.0	[0..1]	[264..1]
gi\|240017051 - gi\|240017051\|ref\|ZP_04723591.1\| thymidylate synthase [Neisseria gonorrhoeae FA6140] gi\|240014606 - gi\|240014606\|ref\|ZP_04721519.1\| thymidylate synthase [Neisseria gonorrhoeae DGI18] gi\|239999430 - gi\|239999430\|ref\|ZP_04719354.1\| thymidylate synthase [Neisseria gonorrhoeae 35/02] gi\|240118411 - gi\|240118411\|ref\|ZP_04732473.1\| thymidylate synthase [Neisseria gonorrhoeae PID1] gi\|240116127 - gi\|240116127\|ref\|ZP_04730189.1\| thymidylate synthase [Neisseria gonorrhoeae PID18] gi\|240113520 - gi\|240113520\|ref\|ZP_04728010.1\| thymidylate synthase [Neisseria gonorrhoeae MS11] gi\|240081310 - gi\|240081310\|ref\|ZP_04725853.1\| thymidylate synthase [Neisseria gonorrhoeae FA19] TYSY_NEIG1 - Thymidylate synthase OS=Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090) GN=thyA PE=3 SV=1 gi\|240128633 - gi\|240128633\|ref\|ZP_04741294.1\| thymidylate synthase [Neisseria gonorrhoeae SK-93-1035] gi\|240126156 - gi\|240126156\|ref\|ZP_04739042.1\| thymidylate synthase [Neisseria gonorrhoeae SK-92-679] gi\|240123956 - gi\|240123956\|ref\|ZP_04736912.1\| thymidylate synthase [Neisseria gonorrhoeae PID332] gi\|240121128 - gi\|240121128\|ref\|ZP_04734090.1\| thymidylate synthase [Neisseria gonorrhoeae PID24-1] gi\|226513187, gi... - gi\|254494147\|ref\|ZP_05107318.1\| thymidylate synthase [Neisseria gonorrhoeae 1291], gi\|226513187\|gb\|E...	456.0	[0..1]	[264..1]
TYSY_CHRVO - Thymidylate synthase OS=Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 1... TYSY_CHRVO - Thymidylate synthase OS=Chromobacterium violaceum GN=thyA PE=3 SV=1	456.0	[0..1]	[264..1]
TYSY_METFK - Thymidylate synthase OS=Methylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875) GN=thyA1 PE=...	455.0	[0..1]	[264..1]
TYSY_BRADU - Thymidylate synthase OS=Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / U... TYSY_BRAJA - Thymidylate synthase OS=Bradyrhizobium japonicum GN=thyA PE=3 SV=1	455.0	[0..1]	[264..1]
gi\|157830328, gi... - gi\|3891614\|pdb\|1AXW\|B Chain B, E. Coli Thymidylate Synthase In Complex With Methotrexate (Mtx) And 2...	454.0	[0..1]	[264..2]
TYSY_SHIDS - Thymidylate synthase OS=Shigella dysenteriae serotype 1 (strain Sd197) GN=thyA PE=3 SV=1	454.0	[0..1]	[264..1]
gi\|253323363, gi... - gi\|254289514\|ref\|YP_003055262.1\| thymidylate synthase [Escherichia coli BL21(DE3)], gi\|253978821\|gb\|... gi\|242378375, gi... - gi\|251786102\|ref\|YP_003000406.1\| hypothetical protein B21_02636 [Escherichia coli BL21], gi\|24237837... gi\|253974656, gi... - gi\|254162755\|ref\|YP_003045863.1\| thymidylate synthase [Escherichia coli B str. REL606], gi\|253974656... gi\|83584784, gi\|... - gi\|83584784\|ref\|ZP_00923446.1\| COG0207: Thymidylate synthase [Escherichia coli 101-1], gi\|194439864\|...	454.0	[0..1]	[264..1]
TYSY_ECOLC - Thymidylate synthase OS=Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks) GN=thyA PE=3 SV=1 TYSY_ECOHS - Thymidylate synthase OS=Escherichia coli O9:H4 (strain HS) GN=thyA PE=3 SV=1 gi\|124500314, gi... - gi\|124528786\|ref\|ZP_01700010.1\| Thymidylate synthase [Escherichia coli B], gi\|124500314\|gb\|EAY47789....	453.0	[0..1]	[264..1]

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Predicted Domain #1

Region A:
Residues: [1-264]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKQYLELMQK VLDEGTQKND RTGTGTLSIF GHQMRFNLQD GFPLVTTKRC HLRSIIHELL  60
   61 WFLQGDTNIA YLHENNVTIW DEWADENGDL GPVYGKQWRA WPTPDGRHID QITTVLNQLK 120
  121 NDPDSRRIIV SAWNVGELDK MALAPCHAFF QFYVADGKLS CQLYQRSCDV FLGLPFNIAS 180
  181 YALLVHMMAQ QCDLEVGDFV WTGGDTHLYS NHMDQTHLQL SREPRPLPKL IIKRKPESIF 240
  241 DYRFEDFEIE GYDPHPGIKA PVAI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	128.0
Match:	1f4bA
Description:	Thymidylate synthase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
thymidylate synthase activity	6.6988475347328	bayes_pls_golite062009
5,10-methylenetetrahydrofolate-dependent methyltransferase activity	6.29181090719132	bayes_pls_golite062009
binding	1.89072001556053	bayes_pls_golite062009
catalytic activity	1.73427871128495	bayes_pls_golite062009
transferase activity	1.72626940963556	bayes_pls_golite062009
methyltransferase activity	0.927096828883487	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	0.91282507161672	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: