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View Structure Prediction Details

Protein: gi|168279093
Organism: synthetic construct
Length: 737 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|168279093.

Description E-value Query
Range
Subject
Range
gi|49359177 - gi|49359177|gb|AAT65503.1| protein kinase C epsilon [Rattus norvegicus]
0.0 [1..737] [1..737]
gi|183396893, gi... - gi|183396893|gb|AAI65948.1| Protein kinase C, epsilon [synthetic construct], gi|117616658|gb|ABK4234...
KPCE_MOUSE - Protein kinase C epsilon type OS=Mus musculus GN=Prkce PE=1 SV=1
0.0 [1..737] [1..737]
gi|73969530 - gi|73969530|ref|XP_851861.1| PREDICTED: similar to Protein kinase C, epsilon type (nPKC-epsilon) iso...
0.0 [1..737] [1..737]
gi|66734 - gi|66734|pir||KIRBCE protein kinase C (EC 2.7.1.-) epsilon - rabbit
0.0 [1..737] [1..736]
gi|109102817, gi... - gi|109102817|ref|XP_001112763.1| PREDICTED: protein kinase C, epsilon isoform 7 [Macaca mulatta], gi...
0.0 [1..737] [1..736]
gi|115529015, gi... - gi|166795947|ref|NP_001107724.1| protein kinase C, epsilon [Xenopus (Silurana) tropicalis], gi|11552...
0.0 [1..734] [1..739]

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Predicted Domain #1
Region A:
Residues: [1-135]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVVFNGLLKI KICEAVSLKP TAWSLRHAVG PRPQTFLLDP YIALNVDDSR IGQTATKQKT  60
   61 NSPAWHDEFV TDVCNGRKIE LAVFHDAPIG YDDFVANCTI QFEELLQNGS RHFEDWIDLE 120
  121 PEGRVYVIID LSGSS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 12.30103
Match: 1gmiA
Description: Domain from protein kinase C epsilon
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
calcium-dependent phospholipid binding 4.44639260287301 bayes_pls_golite062009
binding 2.77482286467294 bayes_pls_golite062009
phospholipid binding 2.74013385479058 bayes_pls_golite062009
protein binding 2.38962673708753 bayes_pls_golite062009
neurexin binding 1.99616093461872 bayes_pls_golite062009
receptor activity 1.8680110497448 bayes_pls_golite062009
molecular transducer activity 1.5224906678897 bayes_pls_golite062009
signal transducer activity 1.5224906678897 bayes_pls_golite062009
lipid binding 1.47484095830847 bayes_pls_golite062009
profilin binding 1.32619249806841 bayes_pls_golite062009
transporter activity 1.2628067945512 bayes_pls_golite062009
cation binding 0.860272194694588 bayes_pls_golite062009
metal ion binding 0.860272194694588 bayes_pls_golite062009
ion binding 0.853522493520737 bayes_pls_golite062009
substrate-specific transporter activity 0.816751946072324 bayes_pls_golite062009
calmodulin binding 0.66928366000251 bayes_pls_golite062009
syntaxin-1 binding 0.655976398483981 bayes_pls_golite062009
hydrolase activity 0.501946993060588 bayes_pls_golite062009
SNARE binding 0.3731056408292 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [136-265]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GEAPKDNEER VFRERMRPRK RQGAVRRRVH QVNGHKFMAT YLRQPTYCSH CRDFIWGVIG  60
   61 KQGYQCQVCT CVVHKRCHEL IITKCAGLKK QETPDQVGSQ RFSVNMPHKF GIHNYKVPTF 120
  121 CDHCGSLLWG 

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 3.22
Match: 1r79A
Description: Solution Structure of The C1 Domain of The Human Diacylglycerol Kinase Delta
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 2.82097223032126 bayes_pls_golite062009
binding 2.71288992341677 bayes_pls_golite062009
protein binding 2.2604757016607 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 2.18539532628368 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 2.07238897772131 bayes_pls_golite062009
DNA binding 2.05972958088217 bayes_pls_golite062009
kinase activity 2.00903309297046 bayes_pls_golite062009
nucleic acid binding 1.91592331431516 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.83466699022067 bayes_pls_golite062009
molecular transducer activity 1.66598460953658 bayes_pls_golite062009
signal transducer activity 1.66598460953658 bayes_pls_golite062009
protein kinase activity 1.61903873760762 bayes_pls_golite062009
transferase activity 1.45394179515146 bayes_pls_golite062009
transcription factor activity 1.38590948364516 bayes_pls_golite062009
GTPase regulator activity 1.12412426198961 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 1.10707685935826 bayes_pls_golite062009
myosin heavy chain kinase activity 1.04998401151243 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.969266093401353 bayes_pls_golite062009
protein serine/threonine kinase activity 0.93378879973188 bayes_pls_golite062009
enzyme regulator activity 0.717794523788476 bayes_pls_golite062009
guanyl-nucleotide exchange factor activity 0.6091533221871 bayes_pls_golite062009
small GTPase regulator activity 0.442062495186646 bayes_pls_golite062009
kinase binding 0.409606963040614 bayes_pls_golite062009
cation binding 0.311967762495891 bayes_pls_golite062009
metal ion binding 0.311967762495891 bayes_pls_golite062009
ion binding 0.307697800147455 bayes_pls_golite062009
catalytic activity 0.216721136299042 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [266-677]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LLRQGLQCKV CKMNVHRRCE TNVAPNCGVD ARGIAKVLAD LGVTPDKITN SGQRRKKLIA  60
   61 GAESPQPASG SSPSEEDRSK SAPTSPCDQE IKELENNIRK ALSFDNRGEE HRAASSPDGQ 120
  121 LMSPGENGEV RQGQAKRLGL DEFNFIKVLG KGSFGKVMLA ELKGKDEVYA VKVLKKDVIL 180
  181 QDDDVDCTMT EKRILALARK HPYLTQLYCC FQTKDRLFFV MEYVNGGDLM FQIQRSRKFD 240
  241 EPRSRFYAAE VTSALMFLHQ HGVIYRDLKL DNILLDAEGH CKLADFGMCK EGILNGVTTT 300
  301 TFCGTPDYIA PEILQELEYG PSVDWWALGV LMYEMMAGQP PFEADNEDDL FESILHDDVL 360
  361 YPVWLSKEAV SILKAFMTKN PHKRLGCVAS QNGEDAIKQH PFFKEIDWVL LE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 47.0
Match: 2ozoA
Description: No description for 2ozoA was found.

Predicted Domain #4
Region A:
Residues: [678-737]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QKKIKPPFKP RIKTKRDVNN FDQDFTREEP VLTLVDEAIV KQINQEEFKG FSYFGEDLMP  60
   61 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 82.0
Match: 2i0eA
Description: No description for 2i0eA was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle