YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|213583108
Organism:	Salmonella enterica subsp. enterica serovar Typhi str. E98-0664
Length:	237 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|213583108.

Description	E-value	Query Range	Subject Range
gi\|167994106, gi... - gi\|205328012\|gb\|EDZ14776.1\| thiol:disulfide interchange protein DsbC [Salmonella enterica subsp. ent... gi\|197243173, gi... - gi\|197264918\|ref\|ZP_03164992.1\| thiol:disulfide interchange protein DsbC [Salmonella enterica subsp.... lcl\|NC_016856.1_... - [gene=dsbC] [protein=thiol:disulfide interchange protein DsbC] [protein_id=YP_005239178.1] [location... DSBC_SALTY - Thiol:disulfide interchange protein DsbC OS=Salmonella typhimurium GN=dsbC PE=3 SV=2 DSBC_SALTY - Thiol:disulfide interchange protein DsbC OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700... DSBC_SALTY - Thiol:disulfide interchange protein dsbC OS=Salmonella typhimurium GN=dsbC PE=3 SV=2	2.0E-68	[1..237]	[1..237]
gi\|62129186, gi\|... - gi\|62181553\|ref\|YP_217970.1\| thiol:disulfide interchange protein DsbC [Salmonella enterica subsp. en...	7.0E-68	[1..237]	[1..237]
gi\|77958936 - gi\|77958936\|ref\|ZP_00822962.1\| COG1651: Protein-disulfide isomerase [Yersinia bercovieri ATCC 43970]	8.0E-64	[1..236]	[1..236]
gi\|110616344, gi... - gi\|110806796\|ref\|YP_690316.1\| thiol:disulfide interchange protein DsbC [Shigella flexneri 5 str. 840... gi\|194431750, gi... - gi\|194431750\|ref\|ZP_03064041.1\| thiol:disulfide interchange protein DsbC [Shigella dysenteriae 1012]... gi\|215266265, gi... - gi\|215488193\|ref\|YP_002330624.1\| thiol:disulfide interchange protein DsbC [Escherichia coli O127:H6 ... gi\|24114147, gi\|... - gi\|24114147\|ref\|NP_708657.1\| thiol:disulfide interchange protein DsbC [Shigella flexneri 2a str. 301... gi\|30042462, gi\|... - gi\|30064205\|ref\|NP_838376.1\| thiol:disulfide interchange protein DsbC [Shigella flexneri 2a str. 245... gi\|170682633, gi... - gi\|170682633\|ref\|YP_001745046.1\| thiol:disulfide interchange protein DsbC [Escherichia coli SMS-3-5]...	3.0E-63	[1..237]	[1..236]
gi\|217319411, gi... - gi\|217327044\|ref\|ZP_03443127.1\| thiol:disulfide interchange protein DsbC [Escherichia coli O157:H7 s... gi\|218555441, gi... - gi\|218555441\|ref\|YP_002388354.1\| thiol:disulfide interchange protein DsbC [Escherichia coli IAI1], g... gi\|254794843, gi... - gi\|254794843\|ref\|YP_003079680.1\| protein disulfide isomerase II [Escherichia coli O157:H7 str. TW143... gi\|238902018, gi... - gi\|238902018\|ref\|YP_002927814.1\| protein disulfide isomerase II [Escherichia coli BW2952], gi\|238863... gi\|83587711, gi\|... - gi\|83587711\|ref\|ZP_00926338.1\| COG1651: Protein-disulfide isomerase [Escherichia coli 101-1], gi\|194... gi\|189377685, gi... - gi\|189377685\|gb\|EDU96101.1\| thiol:disulfide interchange protein DsbC [Escherichia coli O157:H7 str. ... gi\|191166011, gi... - gi\|75230866\|ref\|ZP_00717324.1\| COG1651: Protein-disulfide isomerase [Escherichia coli B7A], gi\|19116... gi\|170018861, gi... - gi\|170018861\|ref\|YP_001723815.1\| thiol:disulfide interchange protein DsbC [Escherichia coli ATCC 873... gi\|169890289, gi... - gi\|170082454\|ref\|YP_001731774.1\| protein disulfide isomerase II [Escherichia coli str. K-12 substr. ... gi\|193070541, gi... - gi\|75234621\|ref\|ZP_00718952.1\| COG1651: Protein-disulfide isomerase [Escherichia coli E110019], gi\|1... gi\|85675705, gi\|... - gi\|89109672\|ref\|AP_003452.1\| protein disulfide isomerase II [Escherichia coli str. K-12 substr. W311... gi\|195936511 - gi\|195936511\|ref\|ZP_03081893.1\| thiol:disulfide interchange protein DsbC [Escherichia coli O157:H7 s... gi\|208727476, gi... - gi\|208807675\|ref\|ZP_03250012.1\| thiol:disulfide interchange protein DsbC [Escherichia coli O157:H7 s... gi\|208813556, gi... - gi\|208813556\|ref\|ZP_03254885.1\| thiol:disulfide interchange protein DsbC [Escherichia coli O157:H7 s... gi\|208740301, gi... - gi\|208820178\|ref\|ZP_03260498.1\| thiol:disulfide interchange protein DsbC [Escherichia coli O157:H7 s... gi\|209399808, gi... - gi\|209399808\|ref\|YP_002272367.1\| thiol:disulfide interchange protein DsbC [Escherichia coli O157:H7 ... gi\|124502305, gi... - gi\|124526201\|ref\|ZP_01698206.1\| protein disulfide isomerase II [Escherichia coli B], gi\|124502305\|gb... DSBC_ECOLI - Thiol:disulfide interchange protein dsbC precursor - Escherichia coli EG11070 - protein disulfide isomerase II / Disulfide bond isomerase, periplasmic; chaperone; activated by DsbD... DSBC_ECO57 - Thiol:disulfide interchange protein DsbC OS=Escherichia coli O157:H7 GN=dsbC PE=3 SV=1 EG11070 - protein disulfide isomerase II / Disulfide bond isomerase, periplasmic; chaperone; activated by DsbD... gi\|13363237, gi\|... - gi\|15833019\|ref\|NP_311792.1\| thiol:disulfide interchange protein DsbC [Escherichia coli O157:H7 str.... gi\|188017772, gi... - gi\|188017772\|gb\|EDU55894.1\| thiol:disulfide interchange protein DsbC [Escherichia coli O157:H7 str. ... gi\|189358620, gi... - gi\|189358620\|gb\|EDU77039.1\| thiol:disulfide interchange protein DsbC [Escherichia coli O157:H7 str. ... gi\|189369348, gi... - gi\|189369348\|gb\|EDU87764.1\| thiol:disulfide interchange protein DsbC [Escherichia coli O157:H7 str. ... gi\|168766886, gi... - gi\|189363718\|gb\|EDU82137.1\| thiol:disulfide interchange protein DsbC [Escherichia coli O157:H7 str. ... gi\|187768809, gi... - gi\|187768809\|gb\|EDU32653.1\| thiol:disulfide interchange protein DsbC [Escherichia coli O157:H7 str. ... gi\|189003356, gi... - gi\|189003356\|gb\|EDU72342.1\| thiol:disulfide interchange protein DsbC [Escherichia coli O157:H7 str. ... gi\|189374036, gi... - gi\|189374036\|gb\|EDU92452.1\| thiol:disulfide interchange protein DsbC [Escherichia coli O157:H7 str. ...	4.0E-63	[1..237]	[1..236]
gi\|82778341, gi\|... - gi\|82778341\|ref\|YP_404690.1\| thiol:disulfide interchange protein DsbC [Shigella dysenteriae Sd197], ...	4.0E-63	[1..237]	[1..236]
gi\|77963235 - gi\|77963235\|ref\|ZP_00827047.1\| COG1651: Protein-disulfide isomerase [Yersinia mollaretii ATCC 43969]	5.0E-63	[1..236]	[1..236]
gi\|254162805, gi... - gi\|254162805\|ref\|YP_003045913.1\| protein disulfide isomerase II [Escherichia coli B str. REL606], gi... gi\|75515324, gi\|... - gi\|75515324\|ref\|ZP_00737508.1\| COG1651: Protein-disulfide isomerase [Escherichia coli 53638], gi\|188... gi\|157068033, gi... - gi\|75196845\|ref\|ZP_00706915.1\| COG1651: Protein-disulfide isomerase [Escherichia coli HS], gi\|157162... gi\|254289565, gi... - gi\|254289565\|ref\|YP_003055313.1\| protein disulfide isomerase II [Escherichia coli BL21(DE3)], gi\|253... gi\|251786151, gi... - gi\|251786151\|ref\|YP_003000455.1\| hypothetical protein B21_02688 [Escherichia coli BL21], gi\|24237842...	6.0E-63	[1..237]	[1..236]
gi\|209913606, gi... - gi\|209920347\|ref\|YP_002294431.1\| thiol:disulfide interchange protein DsbC [Escherichia coli SE11], g... gi\|218696488, gi... - gi\|218696488\|ref\|YP_002404155.1\| thiol:disulfide interchange protein DsbC [Escherichia coli 55989], ... gi\|193063526, gi... - gi\|75258492\|ref\|ZP_00729914.1\| COG1651: Protein-disulfide isomerase [Escherichia coli E22], gi\|19306... gi\|75212493, gi\|... - gi\|75212493\|ref\|ZP_00712517.1\| COG1651: Protein-disulfide isomerase [Escherichia coli B171], gi\|1944...	6.0E-63	[1..237]	[1..236]
gi\|26109716, gi\|... - gi\|26249308\|ref\|NP_755348.1\| thiol:disulfide interchange protein DsbC [Escherichia coli CFT073], gi\|... gi\|237706463, gi... - gi\|237706463\|ref\|ZP_04536944.1\| thiol:disulfide interchange protein DsbC [Escherichia sp. 3_2_53FAA]... gi\|117625124, gi... - gi\|117625124\|ref\|YP_854112.1\| thiol:disulfide interchange protein DsbC [Escherichia coli APEC O1], g... gi\|227888442, gi... - gi\|227888442\|ref\|ZP_04006247.1\| protein disulfide-isomerase [Escherichia coli 83972], gi\|227834711\|g... gi\|218428582, gi... - gi\|218691018\|ref\|YP_002399230.1\| thiol:disulfide interchange protein DsbC [Escherichia coli ED1a], g... gi\|218366655, gi... - gi\|218559886\|ref\|YP_002392799.1\| thiol:disulfide interchange protein DsbC [Escherichia coli S88], gi... gi\|91212271, gi\|... - gi\|91212271\|ref\|YP_542257.1\| thiol:disulfide interchange protein DsbC [Escherichia coli UTI89], gi\|9...	7.0E-63	[1..237]	[1..236]

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Predicted Domain #1

Region A:
Residues: [1-237]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKKRFMMFTL LAAAFSGVAH ADDAAIRQSL AKLGVQSTEI QASPVAGMKT VLTHSGVLYV  60
   61 TDDGKHIIQG PMYDVSGAHP VNVTNKLLMS QLNALEKEMI VYKAPDEKHV ITVFTDITCG 120
  121 YCHKLHEEMK DYNALGITVR YLAFPRQGLE SQAEQDMKSI WCAKDKNKAF DDAMAGKGVK 180
  181 PASCDVNIAD HYALGVQLGV SGTPAIVLSN GYVVPGYQGP KEMKAFLDEH QKQTSGK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	59.522879
Match:	1eejA
Description:	Disulfide bond isomerase, DsbC, C-terminal domain; Disulfide bond isomerase, DsbC, N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein disulfide isomerase activity	1.48801287843472	bayes_pls_golite062009
intramolecular oxidoreductase activity, transposing S-S bonds	1.48801287843472	bayes_pls_golite062009
intramolecular oxidoreductase activity, interconverting keto- and enol-groups	1.37876060576659	bayes_pls_golite062009
catalytic activity	1.04263226837398	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors	0.25957505753521	bayes_pls_golite062009
isomerase activity	0.24662332270942	bayes_pls_golite062009
disulfide oxidoreductase activity	0.22354310938224	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: