YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|190404894
Organism:	Saccharomyces cerevisiae RM11-1a
Length:	463 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|190404894.

Description	E-value	Query Range	Subject Range
ODO2_YEAST - Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, m... gi\|190404894 - gi\|190404894\|gb\|EDV08161.1\| hypothetical protein SCRG_00372 [Saccharomyces cerevisiae RM11-1a] KGD2 - Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase com...	0.0	[1..463]	[1..463]
gi\|227010100, gi... - gi\|227082212\|ref\|YP_002810763.1\| 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succin... gi\|229507825, gi... - gi\|229507825\|ref\|ZP_04397330.1\| dihydrolipoamide succinyltransferase component (E2) of 2-oxoglutarat... gi\|9656634, gi\|1... - gi\|9656634\|gb\|AAF95232.1\| 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltrans... gi\|229343763, gi... - gi\|229519074\|ref\|ZP_04408517.1\| dihydrolipoamide succinyltransferase component (E2) of 2-oxoglutarat... gi\|229607370, gi... - gi\|229607370\|ref\|YP_002878018.1\| dihydrolipoamide succinyltransferase component (E2) of 2-oxoglutara... gi\|75829400, gi\|... - gi\|75829400\|ref\|ZP_00758704.1\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam... gi\|147675118, gi... - gi\|75827393\|ref\|ZP_00756828.1\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam... gi\|121727380, gi... - gi\|75814758\|ref\|ZP_00745311.1\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam... gi\|121586902, gi... - gi\|121586902\|ref\|ZP_01676682.1\| 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succiny... gi\|124119054, gi... - gi\|153222194\|ref\|ZP_01952973.1\| 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succiny... gi\|153818382, gi... - gi\|153818382\|ref\|ZP_01971049.1\| 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succiny... gi\|11257428 - pir\|\|A82121 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase VC2086 ... gi\|229351903, gi... - gi\|229511938\|ref\|ZP_04401417.1\| dihydrolipoamide succinyltransferase component (E2) of 2-oxoglutarat...	0.0	[72..462]	[1..402]
gi\|186697571, gi... - gi\|186894545\|ref\|YP_001871657.1\| dihydrolipoamide succinyltransferase [Yersinia pseudotuberculosis P... gi\|169751723, gi... - gi\|170025189\|ref\|YP_001721694.1\| dihydrolipoamide succinyltransferase [Yersinia pseudotuberculosis Y... gi\|165924674, gi... - gi\|165924674\|ref\|ZP_02220506.1\| 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succiny... gi\|21959982, gi\|... - gi\|22126942\|ref\|NP_670365.1\| dihydrolipoamide acetyltransferase [Yersinia pestis KIM], gi\|21959982\|g... gi\|166211260, gi... - gi\|166211260\|ref\|ZP_02237295.1\| 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succiny... gi\|25286448 - pir\|\|AB0137 dihydrolipoamide S-succinyltransferase (EC 2.3.1.61) [imported] - Yersinia pestis (strai... gi\|166011609, gi... - gi\|166011609\|ref\|ZP_02232507.1\| 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succiny... gi\|51595492, gi\|... - gi\|51595492\|ref\|YP_069683.1\| dihydrolipoamide acetyltransferase [Yersinia pseudotuberculosis IP 3295... gi\|166962232, gi... - gi\|167419491\|ref\|ZP_02311244.1\| 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succiny... gi\|45435734, gi\|... - gi\|45440876\|ref\|NP_992415.1\| dihydrolipoamide acetyltransferase [Yersinia pestis biovar Microtus str... gi\|167050555, gi... - gi\|167399847\|ref\|ZP_02305365.1\| 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succiny... gi\|167468939 - gi\|167468939\|ref\|ZP_02333643.1\| 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succiny... gi\|218928282, gi... - gi\|218928282\|ref\|YP_002346157.1\| dihydrolipoamide succinyltransferase [Yersinia pestis CO92], gi\|161... gi\|167057125, gi... - gi\|167424276\|ref\|ZP_02316029.1\| 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succiny... gi\|77636427, gi\|... - gi\|77636427\|ref\|ZP_00798501.1\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam... gi\|77632107, gi\|... - gi\|77632107\|ref\|ZP_00794693.1\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam... gi\|149291260, gi... - gi\|149366886\|ref\|ZP_01888920.1\| dihydrolipoamide succinyltransferase component of 2-oxoglutarate deh... gi\|145599848, gi... - gi\|145599848\|ref\|YP_001163924.1\| dihydrolipoamide acetyltransferase [Yersinia pestis Pestoides F], g... Q66DA1\|Q66DA1_YERPS - Dihydrolipoamide succinyltransferase component of 2-oxoglutar... - Yersinia pseudotuberculosis gi\|89105201, gi\|... - gi\|89105201\|ref\|ZP_01177725.1\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam... gi\|108806589, gi... - gi\|108806589\|ref\|YP_650505.1\| dihydrolipoamide acetyltransferase [Yersinia pestis Antiqua], gi\|10877... gi\|229697416, gi... - gi\|229841050\|ref\|ZP_04461209.1\| dihydrolipoyltranssuccinase [Yersinia pestis biovar Orientalis str. ... gi\|229843154, gi... - gi\|229843154\|ref\|ZP_04463300.1\| dihydrolipoyltranssuccinase [Yersinia pestis biovar Orientalis str. ... gi\|229703876, gi... - gi\|229893991\|ref\|ZP_04509177.1\| dihydrolipoyltranssuccinase [Yersinia pestis Pestoides A], gi\|229703... gi\|229903485, gi... - gi\|229903485\|ref\|ZP_04518598.1\| dihydrolipoyltranssuccinase [Yersinia pestis Nepal516], gi\|229679255...	0.0	[71..462]	[1..405]
gi\|15602143, gi\|... - gi\|15602143\|ref\|NP_245215.1\| hypothetical protein PM0278 [Pasteurella multocida subsp. multocida str...	0.0	[71..462]	[1..402]
gi\|73854728, gi\|... - gi\|74311251\|ref\|YP_309670.1\| dihydrolipoamide acetyltransferase [Shigella sonnei Ss046], gi\|73854728... gi\|168777543, gi... - gi\|187767227\|gb\|EDU31071.1\| dihydrolipoyllysine-residue succinyltransferase, E2 component of oxoglut... gi\|194421839, gi... - gi\|83585342\|ref\|ZP_00923989.1\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam... gi\|189002966, gi... - gi\|189002966\|gb\|EDU71952.1\| dihydrolipoyllysine-residue succinyltransferase, E2 component of oxoglut... gi\|189372983, gi... - gi\|189372983\|gb\|EDU91399.1\| dihydrolipoyllysine-residue succinyltransferase, E2 component of oxoglut... gi\|189376474, gi... - gi\|189376474\|gb\|EDU94890.1\| dihydrolipoyllysine-residue succinyltransferase, E2 component of oxoglut... gi\|193070661, gi... - gi\|75234495\|ref\|ZP_00718842.1\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam... gi\|170020929, gi... - gi\|170020929\|ref\|YP_001725883.1\| dihydrolipoamide succinyltransferase [Escherichia coli ATCC 8739], ... gi\|75511614, gi\|... - gi\|75511614\|ref\|ZP_00734265.1\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam... gi\|170080393, gi... - gi\|170080393\|ref\|YP_001729713.1\| dihydrolipoyltranssuccinase [Escherichia coli str. K-12 substr. DH1... gi\|75189748, gi\|... - gi\|75189748\|ref\|ZP_00703015.1\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam... gi\|170518735, gi... - gi\|170681017\|ref\|YP_001742827.1\| dihydrolipoyllysine-residue succinyltransferase, E2 component of ox... gi\|75229641, gi\|... - gi\|75229641\|ref\|ZP_00716178.1\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam... gi\|194417748, gi... - gi\|194433983\|ref\|ZP_03066254.1\| dihydrolipoyllysine-residue succinyltransferase, E2 component of oxo... gi\|13360210, gi\|... - gi\|15830006\|ref\|NP_308779.1\| dihydrolipoamide succinyltransferase [Escherichia coli O157:H7 str. Sak... gi\|188015221, gi... - gi\|188015221\|gb\|EDU53343.1\| dihydrolipoyllysine-residue succinyltransferase, E2 component of oxoglut... gi\|168757180, gi... - gi\|189355777\|gb\|EDU74196.1\| dihydrolipoyllysine-residue succinyltransferase, E2 component of oxoglut... gi\|189365937, gi... - gi\|189365937\|gb\|EDU84353.1\| dihydrolipoyllysine-residue succinyltransferase, E2 component of oxoglut... gi\|1651322, gi\|8... - gi\|89107584\|ref\|AP_001364.1\| dihydrolipoyltranssuccinase [Escherichia coli str. K-12 substr. W3110],... gi\|189363360, gi... - gi\|189363360\|gb\|EDU81779.1\| dihydrolipoyllysine-residue succinyltransferase, E2 component of oxoglut... gi\|218360021, gi... - gi\|218553253\|ref\|YP_002386166.1\| dihydrolipoamide succinyltransferase [Escherichia coli IAI1], gi\|21... gi\|218369067, gi... - gi\|218699081\|ref\|YP_002406710.1\| dihydrolipoamide succinyltransferase [Escherichia coli IAI39], gi\|2... gi\|254791873, gi... - gi\|254791873\|ref\|YP_003076710.1\| dihydrolipoyltranssuccinase [Escherichia coli O157:H7 str. TW14359]... gi\|253972697, gi... - gi\|254160796\|ref\|YP_003043904.1\| dihydrolipoamide acetyltransferase [Escherichia coli B str. REL606]... gi\|195939068 - gi\|195939068\|ref\|ZP_03084450.1\| dihydrolipoamide acetyltransferase [Escherichia coli O157:H7 str. EC... gi\|253325347, gi... - gi\|254287584\|ref\|YP_003053332.1\| dihydrolipoamide acetyltransferase [Escherichia coli BL21(DE3)], gi... ODO2_ECOLI - Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex (E... gi\|208725695, gi... - gi\|208805894\|ref\|ZP_03248231.1\| dihydrolipoyllysine-residue succinyltransferase, E2 component of oxo... gi\|251784215, gi... - gi\|251784215\|ref\|YP_002998519.1\| hypothetical protein B21_00675 [Escherichia coli BL21], gi\|24237648... ODO2_ECO57 - Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex OS... gi\|208815793, gi... - gi\|208815793\|ref\|ZP_03256972.1\| dihydrolipoyllysine-residue succinyltransferase, E2 component of oxo... gi\|238899991, gi... - gi\|238899991\|ref\|YP_002925787.1\| dihydrolipoyltranssuccinase [Escherichia coli BW2952], gi\|238860764... EG10980 - dihydrolipoyltranssuccinase / 2-oxoglutarate dehydrogenase, E2 component; dihydrolipoamide succinylt... gi\|208822873, gi... - gi\|208822873\|ref\|ZP_03263191.1\| dihydrolipoyllysine-residue succinyltransferase, E2 component of oxo... gi\|12513642, gi\|... - gi\|15800431\|ref\|NP_286443.1\| dihydrolipoamide acetyltransferase [Escherichia coli O157:H7 EDL933], g... gi\|209397255, gi... - gi\|209397255\|ref\|YP_002269350.1\| dihydrolipoyllysine-residue succinyltransferase, E2 component of ox... gi\|209917977, gi... - gi\|209917977\|ref\|YP_002292061.1\| dihydrolipoamide succinyltransferase [Escherichia coli SE11], gi\|20... gi\|215263817, gi... - gi\|215485745\|ref\|YP_002328176.1\| dihydrolipoamide succinyltransferase [Escherichia coli O127:H6 str.... gi\|217322317, gi... - gi\|217326096\|ref\|ZP_03442180.1\| dihydrolipoyllysine-residue succinyltransferase, E2 component of oxo... gi\|124526818, gi... - gi\|124526818\|ref\|ZP_01698700.1\| 2-oxoglutarate dehydrogenase, E2 subunit, dihydrolipoamide succinylt... EG10980 - dihydrolipoyltranssuccinase / 2-oxoglutarate dehydrogenase, E2 component; dihydrolipoamide succinylt...	0.0	[71..462]	[1..403]
DBT - dihydrolipoamide branched chain transacylase E2 HGNC:2698\|MIM:24... - branched chain transacylase E2 gi\|61359897, gi\|... - gi\|61359903\|gb\|AAX41784.1\| dihydrolipoamide branched chain transacylase [synthetic construct], gi\|61...	0.0	[9..462]	[3..479]
ODO2_RICPR - Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex OS... ODO2_RICPR - Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex OS...	0.0	[72..462]	[1..399]
gi\|15614768, gi\|... - gi\|15614768\|ref\|NP_243071.1\| dihydrolipoamide acetyltransferase [Bacillus halodurans C-125], gi\|1017... gi\|25286430 - pir\|\|E83925 dihydrolipoamide succinyltransferase BH2205 [imported] - Bacillus halodurans (strain C-1...	0.0	[74..462]	[2..409]

Back

Predicted Domain #1

Region A:
Residues: [1-70]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLSRATRTAA AKSLVKSKVA RNVMAASFVK RHASTSLFKQ ANKVESLGSI YLSGKKISVA  60
   61 ANPFSITSNR

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [71-182]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FKSTSIEVPP MAESLTEGSL KEYTKNVGDF IKEDELLATI ETDKIDIEVN SPVSGTVTKL  60
   61 NFKPEDTVTV GEELAQVEPG EAPAEGSGES KPEPTEQAEP SQGVAARENS SE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	67.9897
Match:	1lab__
Description:	Ipoyl domain of dihydrolipoamide acetyltransferase
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [183-231]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ETASKKEAAP KKEAAPKKEV TEPKKADQPK KTVSKAQEPP VASNSFTPF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	4.09691
Match:	2pdd__
Description:	E3/E1 binding domain of dihydrolipoyl acetyltransferase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
S-succinyltransferase activity	10.0778678835755	bayes_pls_golite062009
dihydrolipoyllysine-residue succinyltransferase activity	10.0778678835755	bayes_pls_golite062009
S-acyltransferase activity	9.57991961071442	bayes_pls_golite062009
succinyltransferase activity	6.58826720904067	bayes_pls_golite062009
acyltransferase activity	6.14362200989279	bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups	6.13552509992797	bayes_pls_golite062009
dihydrolipoamide S-acyltransferase activity	4.1573115612763	bayes_pls_golite062009
dihydrolipoyllysine-residue acetyltransferase activity	3.95619571226032	bayes_pls_golite062009
transferase activity, transferring acyl groups	3.91600160749755	bayes_pls_golite062009
S-acetyltransferase activity	3.80731268500197	bayes_pls_golite062009
carnitine O-acyltransferase activity	1.95284873022177	bayes_pls_golite062009
catalytic activity	1.51562638409295	bayes_pls_golite062009
pyruvate dehydrogenase activity	1.47989209806246	bayes_pls_golite062009
O-acyltransferase activity	1.33852311685118	bayes_pls_golite062009
acetyltransferase activity	1.12787027896966	bayes_pls_golite062009
transferase activity	1.08341671157927	bayes_pls_golite062009
binding	0.801074244553007	bayes_pls_golite062009
O-palmitoyltransferase activity	0.36133273832704	bayes_pls_golite062009
carnitine O-palmitoyltransferase activity	0.36133273832704	bayes_pls_golite062009
carnitine O-acetyltransferase activity	0.154650266774881	bayes_pls_golite062009
O-acetyltransferase activity	0.1424856707148	bayes_pls_golite062009
protein binding	0.00454070917775817	bayes_pls_golite062009

Predicted Domain #4

Region A:
Residues: [232-463]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PRTETRVKMN RMRLRIAERL KESQNTAASL TTFNEVDMSA LMEMRKLYKD EIIKKTGTKF  60
   61 GFMGLFSKAC TLAAKDIPAV NGAIEGDQIV YRDYTDISVA VATPKGLVTP VVRNAESLSV 120
  121 LDIENEIVRL SHKARDGKLT LEDMTGGTFT ISNGGVFGSL YGTPIINSPQ TAVLGLHGVK 180
  181 ERPVTVNGQI VSRPMMYLAL TYDHRLLDGR EAVTFLKTVK ELIEDPRKML LW

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	870.0
Match:	1c4tA_
Description:	Dihydrolipoamide succinyltransferase
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: