YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|194712419, gi...
Organism:	Salmonella enterica subsp. enterica serovar Schwarzengrund str. CVM19633
Length:	402 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|194712419, gi....

Description	E-value	Query Range	Subject Range
gi\|89073521, gi\|... - gi\|89073521\|ref\|ZP_01160044.1\| dihydrolipoamide acetyltransferase [Photobacterium sp. SKA34], gi\|890...	0.0	[3..402]	[2..401]
gi\|90438940, gi\|... - gi\|90580055\|ref\|ZP_01235863.1\| dihydrolipoamide acetyltransferase [Vibrio angustum S14], gi\|90438940...	0.0	[3..402]	[2..401]
gi\|15602143, gi\|... - gi\|15602143\|ref\|NP_245215.1\| hypothetical protein PM0278 [Pasteurella multocida subsp. multocida str...	0.0	[1..402]	[1..404]
gi\|126096730, gi... - gi\|126207938\|ref\|YP_001053163.1\| dihydrolipoyllysine-residue succinyltransferase component of 2-oxog... gi\|32034768 - gi\|32034768\|ref\|ZP_00134893.1\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam... gi\|189914931, gi... - gi\|190149800\|ref\|YP_001968325.1\| dihydrolipoyllysine-residue succinyltransferase component of 2-oxog...	0.0	[3..402]	[2..409]
gi\|28805834 - gi\|28805834\|dbj\|BAC59111.1\| 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltra... gi\|153838606, gi... - gi\|153838606\|ref\|ZP_01991273.1\| 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succiny... gi\|28805834, gi\|... - gi\|28897622\|ref\|NP_797227.1\| dihydrolipoamide acetyltransferase [Vibrio parahaemolyticus RIMD 221063...	0.0	[3..402]	[2..401]
gi\|53732513 - gi\|53732513\|ref\|ZP_00154561.2\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam... gi\|48868188, gi\|... - gi\|68250263\|ref\|YP_249375.1\| dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydr...	0.0	[3..402]	[2..409]
gi\|186697571, gi... - gi\|186894545\|ref\|YP_001871657.1\| dihydrolipoamide succinyltransferase [Yersinia pseudotuberculosis P... gi\|169751723, gi... - gi\|170025189\|ref\|YP_001721694.1\| dihydrolipoamide succinyltransferase [Yersinia pseudotuberculosis Y... gi\|165924674, gi... - gi\|165924674\|ref\|ZP_02220506.1\| 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succiny... gi\|21959982, gi\|... - gi\|22126942\|ref\|NP_670365.1\| dihydrolipoamide acetyltransferase [Yersinia pestis KIM], gi\|21959982\|g... gi\|166211260, gi... - gi\|166211260\|ref\|ZP_02237295.1\| 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succiny... gi\|25286448 - pir\|\|AB0137 dihydrolipoamide S-succinyltransferase (EC 2.3.1.61) [imported] - Yersinia pestis (strai... gi\|166011609, gi... - gi\|166011609\|ref\|ZP_02232507.1\| 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succiny... gi\|51595492, gi\|... - gi\|51595492\|ref\|YP_069683.1\| dihydrolipoamide acetyltransferase [Yersinia pseudotuberculosis IP 3295... gi\|166962232, gi... - gi\|167419491\|ref\|ZP_02311244.1\| 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succiny... gi\|45435734, gi\|... - gi\|45440876\|ref\|NP_992415.1\| dihydrolipoamide acetyltransferase [Yersinia pestis biovar Microtus str... gi\|167050555, gi... - gi\|167399847\|ref\|ZP_02305365.1\| 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succiny... gi\|167468939 - gi\|167468939\|ref\|ZP_02333643.1\| 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succiny... gi\|218928282, gi... - gi\|218928282\|ref\|YP_002346157.1\| dihydrolipoamide succinyltransferase [Yersinia pestis CO92], gi\|161... gi\|167057125, gi... - gi\|167424276\|ref\|ZP_02316029.1\| 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succiny... gi\|77636427, gi\|... - gi\|77636427\|ref\|ZP_00798501.1\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam... gi\|77632107, gi\|... - gi\|77632107\|ref\|ZP_00794693.1\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam... gi\|149291260, gi... - gi\|149366886\|ref\|ZP_01888920.1\| dihydrolipoamide succinyltransferase component of 2-oxoglutarate deh... gi\|145599848, gi... - gi\|145599848\|ref\|YP_001163924.1\| dihydrolipoamide acetyltransferase [Yersinia pestis Pestoides F], g... Q66DA1\|Q66DA1_YERPS - Dihydrolipoamide succinyltransferase component of 2-oxoglutar... - Yersinia pseudotuberculosis gi\|89105201, gi\|... - gi\|89105201\|ref\|ZP_01177725.1\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam... gi\|108806589, gi... - gi\|108806589\|ref\|YP_650505.1\| dihydrolipoamide acetyltransferase [Yersinia pestis Antiqua], gi\|10877... gi\|229697416, gi... - gi\|229841050\|ref\|ZP_04461209.1\| dihydrolipoyltranssuccinase [Yersinia pestis biovar Orientalis str. ... gi\|229843154, gi... - gi\|229843154\|ref\|ZP_04463300.1\| dihydrolipoyltranssuccinase [Yersinia pestis biovar Orientalis str. ... gi\|229703876, gi... - gi\|229893991\|ref\|ZP_04509177.1\| dihydrolipoyltranssuccinase [Yersinia pestis Pestoides A], gi\|229703... gi\|229903485, gi... - gi\|229903485\|ref\|ZP_04518598.1\| dihydrolipoyltranssuccinase [Yersinia pestis Nepal516], gi\|229679255...	0.0	[1..402]	[1..407]
gi\|238726790, gi... - gi\|77978043\|ref\|ZP_00833478.1\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam...	0.0	[1..402]	[1..406]
gi\|124115754, gi... - gi\|153213693\|ref\|ZP_01948945.1\| 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succiny... gi\|229528898, gi... - gi\|229528898\|ref\|ZP_04418288.1\| dihydrolipoamide succinyltransferase component (E2) of 2-oxoglutarat... gi\|229348922, gi... - gi\|229513741\|ref\|ZP_04403203.1\| dihydrolipoamide succinyltransferase component (E2) of 2-oxoglutarat... gi\|194535435, gi... - gi\|75823423\|ref\|ZP_00752925.1\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam... gi\|254286797, gi... - gi\|254286797\|ref\|ZP_04961750.1\| 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succiny... tr\|D7HAD6\|D7HAD6... - Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex OS... gi\|75819459, gi\|... - gi\|75819459\|ref\|ZP_00749538.1\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam...	0.0	[3..402]	[2..404]
gi\|23467322, gi\|... - gi\|23467322\|ref\|ZP_00122905.1\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam...	0.0	[1..402]	[1..407]

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Predicted Domain #1

Region A:
Residues: [1-89]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSVDILVPD LPESVADATV ATWHKKPGDA VVRDEVLVEI ETDKVVLEVP ASADGILDAV  60
   61 LEEEGTTVTS RQILGRLREG NSAGKETSA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	14.0
Match:	1pmrA
Description:	LIPOYL DOMAIN FROM THE DIHYDROLIPOYL SUCCINYLTRANSFERASE COMPONENT OF THE 2-OXOGLUTARATE DEHYDROGENASE MULTIENZYME COMPLEX OF ESCHERICHIA COLI, NMR, 25 STRUCTURES
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
dihydrolipoyllysine-residue acetyltransferase activity	7.74877411346968	bayes_pls_golite062009
S-acetyltransferase activity	7.59642806209362	bayes_pls_golite062009
dihydrolipoamide S-acyltransferase activity	7.45508609960612	bayes_pls_golite062009
pyruvate dehydrogenase activity	7.05950875585975	bayes_pls_golite062009
S-acyltransferase activity	5.24395351180663	bayes_pls_golite062009
acetyltransferase activity	3.55333192628786	bayes_pls_golite062009
acetyl-CoA carboxylase activity	3.31123635155865	bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups	2.83081843426182	bayes_pls_golite062009
CoA carboxylase activity	2.82233689048595	bayes_pls_golite062009
acyltransferase activity	2.79754636323803	bayes_pls_golite062009
ligase activity, forming carbon-carbon bonds	2.53708026587542	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	2.22092493760605	bayes_pls_golite062009
catalytic activity	1.39099902011318	bayes_pls_golite062009
binding	0.988780943163898	bayes_pls_golite062009
transferase activity, transferring acyl groups	0.629490807878017	bayes_pls_golite062009
ligase activity	0.56894584941056	bayes_pls_golite062009
aminomethyltransferase activity	0.377624262164477	bayes_pls_golite062009
protein binding	0.273657523907432	bayes_pls_golite062009
glycine dehydrogenase (decarboxylating) activity	0.0222922933292004	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor	0.0222922933292004	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [90-177]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KSEEKASTPA QRQQASLEEQ NNDALSPAIR RLLAEHNLEA SAIKGTGVGG RLTREDVEKH  60
   61 LAKGESKAPA VEPAAQPALG ARGEKRVP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	6.0
Match:	2cooA
Description:	Solution structure of the e3_binding domain of dihydrolipoamide branched chaintransacylase
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [178-402]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTRLRKRVAE RLLEAKNSTA MLTTFNEVNM KPIMDLRKQY GEVFEKRHGI RLGFMSFYVK  60
   61 AVVEALKRYP EVNASIDGDD VVYHNYFDVS MAVSTPRGLV TPVLRDVDTL GMADIEKKIK 120
  121 ELAVKGRDGK LTVEDLTGGN FTITNGGVFG SLMSTPIINP PQSAILGMHA IKDRPMAVDG 180
  181 KVEILPMMYL ALSYDHRLID GRESVGFLVT IKELLEDPTR LLLDV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	89.39794
Match:	1c4tA
Description:	Dihydrolipoamide succinyltransferase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
S-succinyltransferase activity	10.0778678835755	bayes_pls_golite062009
dihydrolipoyllysine-residue succinyltransferase activity	10.0778678835755	bayes_pls_golite062009
dihydrolipoyllysine-residue acetyltransferase activity	9.65061123545754	bayes_pls_golite062009
dihydrolipoamide S-acyltransferase activity	9.64995677986911	bayes_pls_golite062009
S-acetyltransferase activity	9.49696044977584	bayes_pls_golite062009
S-acyltransferase activity	8.45313874919036	bayes_pls_golite062009
pyruvate dehydrogenase activity	8.17557182322815	bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups	6.86215901871647	bayes_pls_golite062009
acyltransferase activity	6.83977352892719	bayes_pls_golite062009
succinyltransferase activity	6.58826720904067	bayes_pls_golite062009
pyruvate dehydrogenase (acetyl-transferring) activity	6.40483178382327	bayes_pls_golite062009
acetyltransferase activity	6.08159176722072	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	5.93985773477717	bayes_pls_golite062009
transferase activity, transferring acyl groups	4.60481199262496	bayes_pls_golite062009
alpha-ketoacid dehydrogenase activity	4.42757758312016	bayes_pls_golite062009
carnitine O-acyltransferase activity	2.87366177129153	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	2.54513901872655	bayes_pls_golite062009
catalytic activity	1.51562638409295	bayes_pls_golite062009
O-acyltransferase activity	1.33852311685118	bayes_pls_golite062009
O-palmitoyltransferase activity	1.22729402619659	bayes_pls_golite062009
carnitine O-palmitoyltransferase activity	1.22729402619659	bayes_pls_golite062009
transferase activity	1.08341671157927	bayes_pls_golite062009
carnitine O-acetyltransferase activity	1.00868366840715	bayes_pls_golite062009
binding	0.801074244553007	bayes_pls_golite062009
O-acetyltransferase activity	0.54660034926676	bayes_pls_golite062009
protein binding	0.00454070917775817	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: