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View Structure Prediction Details

Protein: MARK1
Organism: Homo sapiens
Length: 795 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MARK1.

Description E-value Query
Range
Subject
Range
MARK1 - MAP/microtubule affinity-regulating kinase 1
675.0 [0..1] [795..1]
MARK1_MOUSE - Serine/threonine-protein kinase MARK1 OS=Mus musculus GN=Mark1 PE=1 SV=1
672.0 [0..1] [795..1]
gi|114572747 - gi|114572747|ref|XP_001172839.1| PREDICTED: MAP/microtubule affinity-regulating kinase 1 isoform 7 [...
668.0 [0..1] [795..1]
MARK1_RAT - Serine/threonine-protein kinase MARK1 OS=Rattus norvegicus GN=Mark1 PE=1 SV=1
664.0 [0..1] [795..1]
gi|50740239 - gi|50740239|ref|XP_419403.1| PREDICTED: similar to MARK [Gallus gallus]
661.0 [0..18] [795..135]
gi|74006197 - gi|74006197|ref|XP_536123.2| PREDICTED: similar to Serine/threonine-protein kinase MARK1 (MAP/microt...
651.0 [0..18] [795..5]
gi|76636938 - gi|76636938|ref|XP_588081.2| PREDICTED: similar to Serine/threonine-protein kinase MARK1 (MAP/microt...
643.0 [0..18] [795..9]

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Predicted Domain #1
Region A:
Residues: [1-375]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSARTPLPTV NERDTVNHTT VDGYTEPHIQ PTKSSSRQNI PRCRNSITSA TDEQPHIGNY  60
   61 RLQKTIGKGN FAKVKLARHV LTGREVAVKI IDKTQLNPTS LQKLFREVRI MKILNHPNIV 120
  121 KLFEVIETEK TLYLVMEYAS GGEVFDYLVA HGRMKEKEAR AKFRQIVSAV QYCHQKYIVH 180
  181 RDLKAENLLL DGDMNIKIAD FGFSNEFTVG NKLDTFCGSP PYAAPELFQG KKYDGPEVDV 240
  241 WSLGVILYTL VSGSLPFDGQ NLKELRERVL RGKYRIPFYM STDCENLLKK LLVLNPIKRG 300
  301 SLEQIMKDRW MNVGHEEEEL KPYTEPDPDF NDTKRIDIMV TMGFARDEIN DALINQKYDE 360
  361 VMATYILLGR KPPEF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 89.39794
Match: 2hakA
Description: No description for 2hakA was found.

Predicted Domain #2
Region A:
Residues: [376-539]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EGGESLSSGN LCQRSRPSSD LNNSTLQSPA HLKVQRSISA NQKQRRFSDH AGPSIPPAVS  60
   61 YTKRPQANSV ESEQKEEWDK DVARKLGSTT VGSKSEMTAS PLVGPERKKS STIPSNNVYS 120
  121 GGSMARRNTY VCERTTDRYV ALQNGKDSSL TEMSVSSISS AGSS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [540-668]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VASAVPSARP RHQKSMSTSG HPIKVTLPTI KDGSEAYRPG TTQRVPAASP SAHSISTATP  60
   61 DRTRFPRGSS SRSTFHGEQL RERRSVAYNG PPASPSHETG AFAHARRGTS TGIISKITSK 120
  121 FVRRDPSEG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [669-795]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EASGRTDTSR STSGEPKERD KEEGKDSKPR SLRFTWSMKT TSSMDPNDMM REIRKVLDAN  60
   61 NCDYEQKERF LLFCVHGDAR QDSLVQWEME VCKLPRLSLN GVRFKRISGT SIAFKNIASK 120
  121 IANELKL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 42.221849
Match: 1ul7A
Description: Solution structure of kinase associated domain 1 of mouse MAP/microtubule affinity-regulating kinase 3
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle