YRC Public Data Repository - Protein Structure Prediction

Protein:	AROE_ECOBW
Organism:	Escherichia coli BW2952
Length:	272 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for AROE_ECOBW.

Description	E-value	Query Range	Subject Range
gi\|227883413, gi... - gi\|227883413\|ref\|ZP_04001218.1\| shikimate 5-dehydrogenase [Escherichia coli 83972], gi\|227839557\|gb\|... AROE_ECOL6 - Shikimate dehydrogenase OS=Escherichia coli O6 GN=aroE PE=3 SV=1 AROE_ECOL6 - Shikimate dehydrogenase (NADP(+)) OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) GN=...	310.0	[0..1]	[272..1]
gi\|208812766, gi... - gi\|208812766\|ref\|ZP_03254095.1\| shikimate 5-dehydrogenase [Escherichia coli O157:H7 str. EC4045], gi... gi\|208741939, gi... - gi\|208821816\|ref\|ZP_03262136.1\| shikimate 5-dehydrogenase [Escherichia coli O157:H7 str. EC4042], gi... AROE_ECO5E - Shikimate dehydrogenase (NADP(+)) OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) GN=aroE PE=3 SV... gi\|217326063, gi... - gi\|217326063\|ref\|ZP_03442147.1\| shikimate 5-dehydrogenase [Escherichia coli O157:H7 str. TW14588], g... gi\|189374122, gi... - gi\|189374122\|gb\|EDU92538.1\| shikimate 5-dehydrogenase [Escherichia coli O157:H7 str. EC869], gi\|1687... gi\|189375259, gi... - gi\|189375259\|gb\|EDU93675.1\| shikimate 5-dehydrogenase [Escherichia coli O157:H7 str. EC508], gi\|1688... gi\|195939829 - gi\|195939829\|ref\|ZP_03085211.1\| shikimate 5-dehydrogenase [Escherichia coli O157:H7 str. EC4024] gi\|208726033, gi... - gi\|208806232\|ref\|ZP_03248569.1\| shikimate 5-dehydrogenase [Escherichia coli O157:H7 str. EC4206], gi... gi\|168758509, gi... - gi\|189354688\|gb\|EDU73107.1\| shikimate 5-dehydrogenase [Escherichia coli O157:H7 str. EC4401], gi\|168... gi\|189361752, gi... - gi\|189361752\|gb\|EDU80171.1\| shikimate 5-dehydrogenase [Escherichia coli O157:H7 str. EC4486], gi\|168... gi\|187767009, gi... - gi\|187767009\|gb\|EDU30853.1\| shikimate 5-dehydrogenase [Escherichia coli O157:H7 str. EC4196], gi\|168... gi\|188998855, gi... - gi\|188998855\|gb\|EDU67841.1\| shikimate 5-dehydrogenase [Escherichia coli O157:H7 str. EC4076], gi\|168... gi\|12517908, gi\|... - gi\|15803809\|ref\|NP_289843.1\| shikimate 5-dehydrogenase [Escherichia coli O157:H7 EDL933], gi\|1251790... gi\|209757416, gi... - pir\|\|G85992 dehydroshikimate reductase [imported] - Escherichia coli (strain O157:H7, substrain EDL... gi\|188013838, gi... - gi\|188013838\|gb\|EDU51960.1\| shikimate 5-dehydrogenase [Escherichia coli O157:H7 str. EC4113], gi\|168... gi\|254594618, gi... - gi\|254795218\|ref\|YP_003080055.1\| dehydroshikimate reductase, NAD(P)-binding [Escherichia coli O157:H... AROE_ECO57 - Shikimate dehydrogenase (NADP(+)) OS=Escherichia coli O157:H7 GN=aroE PE=3 SV=1 gi\|13363620, gi\|... - gi\|15833401\|ref\|NP_312174.1\| shikimate 5-dehydrogenase [Escherichia coli O157:H7 str. Sakai], gi\|133...	308.0	[0..1]	[272..1]
gi\|192955143, gi... - gi\|75214912\|ref\|ZP_00713391.1\| COG0169: Shikimate 5-dehydrogenase [Escherichia coli E110019], gi\|193... gi\|194411670, gi... - gi\|75208432\|ref\|ZP_00708761.1\| COG0169: Shikimate 5-dehydrogenase [Escherichia coli B171], gi\|194430...	308.0	[0..1]	[272..1]
gi\|191174467, gi... - gi\|75236347\|ref\|ZP_00720454.1\| COG0169: Shikimate 5-dehydrogenase [Escherichia coli F11], gi\|1911744... AROE_ECOL5 - Shikimate dehydrogenase (NADP(+)) OS=Escherichia coli O6:K15:H31 (strain 536 / UPEC) GN=aroE PE=3 SV...	308.0	[0..1]	[272..1]
gi\|188490034, gi... - gi\|75511162\|ref\|ZP_00733874.1\| COG0169: Shikimate 5-dehydrogenase [Escherichia coli 53638], gi\|18849...	307.0	[0..1]	[272..1]
AROE_ECO55 - Shikimate dehydrogenase (NADP(+)) OS=Escherichia coli (strain 55989 / EAEC) GN=aroE PE=3 SV=1 AROE_ECOSE - Shikimate dehydrogenase (NADP(+)) OS=Escherichia coli (strain SE11) GN=aroE PE=3 SV=1 gi\|75227399, gi\|... - gi\|75227399\|ref\|ZP_00714175.1\| COG0169: Shikimate 5-dehydrogenase [Escherichia coli B7A], gi\|1911693... AROE_ECO8A - Shikimate dehydrogenase (NADP(+)) OS=Escherichia coli O8 (strain IAI1) GN=aroE PE=3 SV=1 AROE_ECO24 - Shikimate dehydrogenase (NADP(+)) OS=Escherichia coli O139:H28 (strain E24377A / ETEC) GN=aroE PE=3 ...	307.0	[0..1]	[272..1]
AROE_SHIF8 - Shikimate dehydrogenase (NADP(+)) OS=Shigella flexneri serotype 5b (strain 8401) GN=aroE PE=3 SV=1	306.0	[0..1]	[272..1]
gi\|194435087, gi... - gi\|194435087\|ref\|ZP_03067325.1\| shikimate 5-dehydrogenase [Shigella dysenteriae 1012], gi\|194416694\|... AROE_SHIFL - Shikimate dehydrogenase (NADP(+)) OS=Shigella flexneri GN=aroE PE=3 SV=4 gi\|56480305, gi\|... - gi\|56480305\|ref\|NP_709069.2\| shikimate 5-dehydrogenase [Shigella flexneri 2a str. 301], gi\|56383856\|... gi\|30042862, gi\|... - gi\|30064603\|ref\|NP_838774.1\| shikimate 5-dehydrogenase [Shigella flexneri 2a str. 2457T], gi\|3004286...	306.0	[0..1]	[272..1]
gi\|75255420, gi\|... - gi\|75255420\|ref\|ZP_00727232.1\| COG0169: Shikimate 5-dehydrogenase [Escherichia coli E22], gi\|1930664...	306.0	[0..1]	[272..1]
gi\|28949040, gi\|... - gi\|28949043\|pdb\|1NYT\|D Chain D, Shikimate Dehydrogenase Aroe Complexed With Nadp+, gi\|28949042\|pdb\|1...	305.0	[0..1]	[270..1]

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Predicted Domain #1

Region A:
Residues: [1-272]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 METYAVFGNP IAHSKSPFIH QQFAQQLNIE HPYGRVLAPI NDFINTLNAF FSAGGKGANV  60
   61 TVPFKEEAFA RADELTERAA LAGAVNTLMR LEDGRLLGDN TDGVGLLSDL ERLSFIRPGL 120
  121 RILLIGAGGA SRGVLLPLLS LDCAVTITNR TVSRAEELAK LFAHTGSIQA LSMDELEGHE 180
  181 FDLIINATSS GISGDIPAIP SSLIHPGIYC YDMFYQKGKT PFLAWCEQRG SKRNADGLGM 240
  241 LVAQAAHAFL LWHGVLPDVE PVIKQLQEEL SA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	83.045757
Match:	1nytA
Description:	Shikimate 5-dehydrogenase AroE
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.79741889688267	bayes_pls_golite062009
oxidoreductase activity	1.69771604880532	bayes_pls_golite062009
fatty acid synthase activity	0.714637370305282	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	0.418775403210681	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	0.32207755075663	bayes_pls_golite062009
3-oxoacyl-[acyl-carrier-protein] reductase activity	0.192594057004213	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: