YRC Public Data Repository - Protein Structure Prediction

Protein:	DCUP_ECOBW
Organism:	Escherichia coli BW2952
Length:	354 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DCUP_ECOBW.

Description	E-value	Query Range	Subject Range
DCUP_PSEHT - Uroporphyrinogen decarboxylase OS=Pseudoalteromonas haloplanktis (strain TAC 125) GN=hemE PE=3 SV=1	514.0	[0..1]	[354..1]
DCUP_THICR - Uroporphyrinogen decarboxylase OS=Thiomicrospira crunogena (strain XCL-2) GN=hemE PE=3 SV=1	512.0	[0..1]	[354..1]
DCUP_PSEA6 - Uroporphyrinogen decarboxylase OS=Pseudoalteromonas atlantica (strain T6c / ATCC BAA-1087) GN=hemE P...	509.0	[0..1]	[354..1]
DCUP_PSESM - Uroporphyrinogen decarboxylase OS=Pseudomonas syringae pv. tomato (strain DC3000) GN=hemE PE=3 SV=1 DCUP_PSESM - Uroporphyrinogen decarboxylase OS=Pseudomonas syringae pv. tomato GN=hemE PE=3 SV=1 gi\|213925825, gi... - gi\|213969454\|ref\|ZP_03397591.1\| uroporphyrinogen decarboxylase [Pseudomonas syringae pv. tomato T1],...	507.0	[0..1]	[354..1]
DCUP_PSE14 - Uroporphyrinogen decarboxylase OS=Pseudomonas savastanoi pv. phaseolicola (strain 1448A / Race 6) GN...	506.0	[0..1]	[354..1]
DCUP_ECOL6 - Uroporphyrinogen decarboxylase OS=Escherichia coli O6 GN=hemE PE=3 SV=1 DCUP_ECOL6 - Uroporphyrinogen decarboxylase OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) GN=hem... gi\|227837547, gi... - gi\|227885473\|ref\|ZP_04003278.1\| uroporphyrinogen decarboxylase [Escherichia coli 83972], gi\|22783754... sp\|B7UPF2\|DCUP_ECO27 - Uroporphyrinogen decarboxylase OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=hemE PE=3 SV=... DCUP_ECOK1 - Uroporphyrinogen decarboxylase OS=Escherichia coli O1:K1 / APEC GN=hemE PE=3 SV=1 gi\|226903077, gi... - gi\|237702764\|ref\|ZP_04533245.1\| uroporphyrinogen decarboxylase [Escherichia sp. 3_2_53FAA], gi\|22690... DCUP_ECO27 - Uroporphyrinogen decarboxylase OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=hemE PE=3 SV=... DCUP_ECO45 - Uroporphyrinogen decarboxylase OS=Escherichia coli O45:K1 (strain S88 / ExPEC) GN=hemE PE=3 SV=1 DCUP_ECOUT - Uroporphyrinogen decarboxylase OS=Escherichia coli (strain UTI89 / UPEC) GN=hemE PE=3 SV=1	506.0	[0..1]	[354..1]
gi\|189001799, gi... - gi\|189001799\|gb\|EDU70785.1\| uroporphyrinogen decarboxylase [Escherichia coli O157:H7 str. EC4076], g... DCUP_ECO57 - Uroporphyrinogen decarboxylase OS=Escherichia coli O157:H7 GN=hemE PE=3 SV=1 gi\|168777390, gi... - gi\|187767364\|gb\|EDU31208.1\| uroporphyrinogen decarboxylase [Escherichia coli O157:H7 str. EC4196], g... gi\|254595395, gi... - gi\|254795995\|ref\|YP_003080832.1\| uroporphyrinogen decarboxylase [Escherichia coli O157:H7 str. TW143... gi\|189379217, gi... - gi\|189379217\|gb\|EDU97633.1\| uroporphyrinogen decarboxylase [Escherichia coli O157:H7 str. EC508], gi... gi\|168790357, gi... - gi\|189370169\|gb\|EDU88585.1\| uroporphyrinogen decarboxylase [Escherichia coli O157:H7 str. EC869], gi... gi\|168758607, gi... - gi\|189354597\|gb\|EDU73016.1\| uroporphyrinogen decarboxylase [Escherichia coli O157:H7 str. EC4401], g... gi\|188014036, gi... - gi\|188014036\|gb\|EDU52158.1\| uroporphyrinogen decarboxylase [Escherichia coli O157:H7 str. EC4113], g... gi\|168771469, gi... - gi\|189359758\|gb\|EDU78177.1\| uroporphyrinogen decarboxylase [Escherichia coli O157:H7 str. EC4486], g... gi\|168764577, gi... - gi\|189365451\|gb\|EDU83867.1\| uroporphyrinogen decarboxylase [Escherichia coli O157:H7 str. EC4501], g... gi\|209751708, gi... - pir\|\|H91243 uroporphyrinogen decarboxylase [imported] - Escherichia coli (strain O157:H7, substrain ... gi\|217326346, gi... - gi\|217326346\|ref\|ZP_03442430.1\| uroporphyrinogen decarboxylase [Escherichia coli O157:H7 str. TW1458... DCUP_ECO5E - Uroporphyrinogen decarboxylase OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) GN=hemE PE=3 SV=1 gi\|208728531, gi... - gi\|208808730\|ref\|ZP_03251067.1\| uroporphyrinogen decarboxylase [Escherichia coli O157:H7 str. EC4206... gi\|195939623 - gi\|195939623\|ref\|ZP_03085005.1\| uroporphyrinogen decarboxylase [Escherichia coli O157:H7 str. EC4024... gi\|15834174, gi\|... - gi\|15834174\|ref\|NP_312947.1\| uroporphyrinogen decarboxylase [Escherichia coli O157:H7 str. Sakai], g... gi\|208818935, gi... - gi\|208818935\|ref\|ZP_03259255.1\| uroporphyrinogen decarboxylase [Escherichia coli O157:H7 str. EC4042... gi\|208813578, gi... - gi\|208813578\|ref\|ZP_03254907.1\| uroporphyrinogen decarboxylase [Escherichia coli O157:H7 str. EC4045...	506.0	[0..1]	[354..1]
DCUP_SHIFL - Uroporphyrinogen decarboxylase OS=Shigella flexneri GN=hemE PE=1 SV=1 gi\|24115281, gi\|... - gi\|24115281\|ref\|NP_709791.1\| uroporphyrinogen decarboxylase [Shigella flexneri 2a str. 301], gi\|2405... gi\|30064721, gi\|... - gi\|30064721\|ref\|NP_838892.1\| uroporphyrinogen decarboxylase [Shigella flexneri 2a str. 2457T], gi\|30... DCUP_SHIF8 - Uroporphyrinogen decarboxylase OS=Shigella flexneri serotype 5b (strain 8401) GN=hemE PE=3 SV=1	506.0	[0..1]	[354..1]
DCUP_SACD2 - Uroporphyrinogen decarboxylase OS=Saccharophagus degradans (strain 2-40 / ATCC 43961 / DSM 17024) GN...	505.0	[0..1]	[354..1]
DCUP_PSEPK - Uroporphyrinogen decarboxylase OS=Pseudomonas putida (strain KT2440) GN=hemE PE=3 SV=1	505.0	[0..1]	[354..1]

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Predicted Domain #1

Region A:
Residues: [1-354]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTELKNDRYL RALLRQPVDV TPVWMMRQAG RYLPEYKATR AQAGDFMSLC KNAELACEVT  60
   61 LQPLRRYPLD AAILFSDILT VPDAMGLGLY FEAGEGPRFT SPVTCKADVD KLPIPDPEDE 120
  121 LGYVMNAVRT IRRELKGEVP LIGFSGSPWT LATYMVEGGS SKAFTVIKKM MYADPQALHA 180
  181 LLDKLAKSVT LYLNAQIKAG AQAVMIFDTW GGVLTGRDYQ QFSLYYMHKI VDGLLRENDG 240
  241 RRVPVTLFTK GGGQWLEAMA ETGCDALGLD WTTDIADARR RVGNKVALQG NMDPSMLYAP 300
  301 PARIEEEVAT ILAGFGHGEG HVFNLGHGIH QDVPPEHAGV FVEAVHRLSE QYHR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	126.0
Match:	1r3qA
Description:	Uroporphyrinogen Decarboxylase in complex with coproporphyrinogen-I
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
uroporphyrinogen decarboxylase activity	4.48282084722609	bayes_pls_golite062009
catalytic activity	2.37862248560593	bayes_pls_golite062009
carboxy-lyase activity	1.67493268854029	bayes_pls_golite062009
carbon-carbon lyase activity	1.54242506764415	bayes_pls_golite062009
binding	1.19577203030346	bayes_pls_golite062009
transferase activity	1.11861612545715	bayes_pls_golite062009
protein binding	0.30230496242508	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: