YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|229695588, gi...
Organism:	Yersinia pestis biovar Orientalis str. PEXU2
Length:	457 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|229695588, gi....

Description	E-value	Query Range	Subject Range
gi\|167426999, gi... - gi\|167426999\|ref\|ZP_02318752.1\| protease DegQ [Yersinia pestis biovar Mediaevalis str. K1973002], gi... gi\|166961394, gi... - gi\|167420588\|ref\|ZP_02312341.1\| protease DegQ [Yersinia pestis biovar Orientalis str. MG05-1020], gi... gi\|167049917, gi... - gi\|167400549\|ref\|ZP_02306058.1\| protease DegQ [Yersinia pestis biovar Antiqua str. UG05-0454], gi\|16... gi\|166211981, gi... - gi\|166211981\|ref\|ZP_02238016.1\| protease DegQ [Yersinia pestis biovar Antiqua str. B42003004], gi\|16... gi\|166011389, gi... - gi\|166011389\|ref\|ZP_02232287.1\| protease DegQ [Yersinia pestis biovar Antiqua str. E1979001], gi\|165... gi\|165914624, gi... - gi\|165937519\|ref\|ZP_02226082.1\| protease DegQ [Yersinia pestis biovar Orientalis str. IP275], gi\|165... gi\|165928145, gi... - gi\|165928145\|ref\|ZP_02223977.1\| protease DegQ [Yersinia pestis biovar Orientalis str. F1991016], gi\|... gi\|21956804, gi\|... - gi\|22124057\|ref\|NP_667480.1\| protease [Yersinia pestis KIM], gi\|21956804\|gb\|AAM83731.1\|AE013614_5 se... gi\|162354300, gi... - gi\|162421485\|ref\|YP_001605683.1\| protease [Yersinia pestis Angola], gi\|162354300\|gb\|ABX88248.1\| prot...	9.0E-96	[1..457]	[7..463]
gi\|36787309, gi\|... - gi\|37527873\|ref\|NP_931218.1\| protease precursor DegQ [Photorhabdus luminescens subsp. laumondii TTO1...	1.0E-94	[1..457]	[1..457]
gi\|50119263, gi\|... - gi\|50119263\|ref\|YP_048430.1\| exported protease [Pectobacterium atrosepticum SCRI1043], gi\|49609789\|e...	2.0E-94	[1..457]	[1..456]
gi\|59712832, gi\|... - gi\|59712832\|ref\|YP_205608.1\| serine endoprotease DegP (protease Do), periplasmic [Vibrio fischeri ES...	2.0E-93	[1..457]	[1..455]
gi\|254230593, gi... - gi\|75854018\|ref\|ZP_00761743.1\| COG0265: Trypsin-like serine proteases, typically periplasmic, contai...	2.0E-93	[1..457]	[1..455]
gi\|77973397, gi\|... - gi\|77973397\|ref\|ZP_00828945.1\| COG0265: Trypsin-like serine proteases, typically periplasmic, contai...	9.0E-93	[1..457]	[1..457]
gi\|229344317, gi... - gi\|229519628\|ref\|ZP_04409071.1\| outer membrane stress sensor protease DegQ [Vibrio cholerae RC9], gi... gi\|229342095, gi... - gi\|229520862\|ref\|ZP_04410284.1\| outer membrane stress sensor protease DegQ [Vibrio cholerae TM 11079... gi\|227080749, gi... - gi\|227080749\|ref\|YP_002809300.1\| protease DO [Vibrio cholerae M66-2], gi\|227008637\|gb\|ACP04849.1\| pr... gi\|229507177, gi... - gi\|229507177\|ref\|ZP_04396683.1\| outer membrane stress sensor protease DegQ [Vibrio cholerae BX 33028... gi\|15640588, gi\|... - gi\|9654996\|gb\|AAF93734.1\| protease DO [Vibrio cholerae O1 biovar El Tor str. N16961], gi\|15640588\|re... gi\|11278798 - pir\|\|F82307 proteinase DO VC0566 [imported] - Vibrio cholerae (strain N16961 serogroup O1) gi\|229606145, gi... - gi\|229606145\|ref\|YP_002876793.1\| outer membrane stress sensor protease DegQ [Vibrio cholerae MJ-1236... gi\|121591583, gi... - gi\|121591583\|ref\|ZP_01678838.1\| protease DO [Vibrio cholerae 2740-80], gi\|121546565\|gb\|EAX56765.1\| p... gi\|124120842, gi... - gi\|153803624\|ref\|ZP_01958210.1\| protease DO [Vibrio cholerae MZO-3], gi\|124120842\|gb\|EAY39585.1\| pro... gi\|153224050, gi... - gi\|153224050\|ref\|ZP_01954195.1\| protease DO [Vibrio cholerae MAK 757], gi\|124117870\|gb\|EAY36613.1\| p... gi\|126518367, gi... - gi\|229509162\|ref\|ZP_04398647.1\| outer membrane stress sensor protease DegQ [Vibrio cholerae B33], gi... gi\|125617304 - gi\|125617304\|gb\|EAZ45876.1\| protease DO [Vibrio cholerae MO10] gi\|153830227, gi... - gi\|153830227\|ref\|ZP_01982894.1\| protease DO [Vibrio cholerae 623-39], gi\|148874287\|gb\|EDL72422.1\| pr... gi\|147673156, gi... - gi\|227116942\|ref\|YP_002818838.1\| protease DO [Vibrio cholerae O395], gi\|227012392\|gb\|ACP08602.1\| pro...	3.0E-92	[1..457]	[2..456]
gi\|22122030 - gi\|22122030\|dbj\|BAC07235.1\| DegQ serine protease [Photobacterium damselae subsp. piscicida]	2.0E-91	[1..457]	[1..455]
gi\|121627980, gi... - gi\|75814059\|ref\|ZP_00744710.1\| COG0265: Trypsin-like serine proteases, typically periplasmic, contai...	3.0E-91	[23..457]	[12..446]
gi\|54310328, gi\|... - gi\|54310328\|ref\|YP_131348.1\| putative DegQ serine protease [Photobacterium profundum SS9], gi\|469147...	5.0E-91	[1..457]	[1..455]

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Predicted Domain #1

Region A:
Residues: [1-457]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKKTSLLLSA LAISVGLGLA SVPMVSAAAL PAAVAGQTLP SLAPMLEKVL PAVVSVHVSG  60
   61 SQAQQQRLPE EFKFFFGPNA PSGKESSRPF EGLGSGVIIN AEKGYILTNN HVINNADKIR 120
  121 VQLNDGREYD AKLLGRDEQT DIALLQLTDA KNLTAIKIAD SDNLRVGDFA VAVGNPFGLG 180
  181 QTATSGIISA LGRSGLNLEG LENFIQTDAS INRGNSGGAL VNLDGELIGI NTAILAPGGG 240
  241 NIGIGFAIPS NMAQNLSQQL IEFGEVKRGL LGIRGSEMTA DIAKAFNIDA QRGAFVSEVL 300
  301 PKSAAAKAGI KPGDVLISVD GKKISSFAEL RAKVGTTGPG KTIKIGLLRE GKPLEVSVTL 360
  361 DNSSSTSTSA ENLSPSLQGA SLSNGELKDG SKGIKVDSVT KGSPAAQSGL QKDDVIIAVN 420
  421 RERVKDIAEL RKAIEAKPAV IALNIVRGED NIYLLIR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	80.0
Match:	1ky9A
Description:	Protease Do (DegP, HtrA), C-terminal domains; Protease Do (DegP, HtrA), catalytic domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
peptidase activity	5.28251016030465	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	4.93232564230667	bayes_pls_golite062009
endopeptidase activity	4.76863192965644	bayes_pls_golite062009
hydrolase activity	4.7420645083083	bayes_pls_golite062009
serine hydrolase activity	3.40985043278892	bayes_pls_golite062009
serine-type peptidase activity	3.40724860044542	bayes_pls_golite062009
serine-type endopeptidase activity	3.13486560415684	bayes_pls_golite062009
catalytic activity	1.40927913545237	bayes_pls_golite062009
protein binding	0.0013332686405948	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: