YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|227838885, gi...
Organism:	Escherichia coli 83972
Length:	255 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|227838885, gi....

Description	E-value	Query Range	Subject Range
gi\|90579339, gi\|... - gi\|90579339\|ref\|ZP_01235149.1\| putative pyruvate formate-lyase 1 activating enzyme [Vibrio angustum ...	198.0	[0..10]	[255..1]
gi\|90412861, gi\|... - gi\|90412861\|ref\|ZP_01220861.1\| putative pyruvate formate-lyase 1 activating enzyme [Photobacterium p...	195.0	[0..10]	[255..1]
tr\|D7H9T4\|D7H9T4... - Pyruvate formate-lyase 1 activating enzyme OS=Vibrio cholerae RC385 GN=VCRC385_01301 PE=4 SV=1 gi\|150420196, gi... - gi\|75824114\|ref\|ZP_00753580.1\| COG1180: Pyruvate-formate lyase-activating enzyme [Vibrio cholerae RC...	194.0	[0..10]	[255..1]
gi\|153213085, gi... - gi\|153213085\|ref\|ZP_01948623.1\| pyruvate formate-lyase 1 activating enzyme [Vibrio cholerae 1587], g... gi\|229347954, gi... - gi\|229515249\|ref\|ZP_04404709.1\| pyruvate formate-lyase activating enzyme [Vibrio cholerae TMA 21], g... gi\|153222986, gi... - gi\|153222986\|ref\|ZP_01953576.1\| pyruvate formate-lyase 1 activating enzyme [Vibrio cholerae MAK 757]... gi\|229343554, gi... - gi\|229518865\|ref\|ZP_04408308.1\| pyruvate formate-lyase activating enzyme [Vibrio cholerae RC9], gi\|2... gi\|153818851, gi... - gi\|153818851\|ref\|ZP_01971518.1\| pyruvate formate-lyase 1 activating enzyme [Vibrio cholerae NCTC 845... gi\|229342695, gi... - gi\|229520329\|ref\|ZP_04409755.1\| pyruvate formate-lyase activating enzyme [Vibrio cholerae TM 11079-8... gi\|229351692, gi... - gi\|229511727\|ref\|ZP_04401206.1\| pyruvate formate-lyase activating enzyme [Vibrio cholerae B33], gi\|2... gi\|229337469, gi... - gi\|229523888\|ref\|ZP_04413293.1\| pyruvate formate-lyase activating enzyme [Vibrio cholerae bv. albens... gi\|229529108, gi... - gi\|229529108\|ref\|ZP_04418498.1\| pyruvate formate-lyase activating enzyme [Vibrio cholerae 12129(1)],... gi\|229370236, gi... - gi\|229607581\|ref\|YP_002878229.1\| pyruvate formate-lyase activating enzyme [Vibrio cholerae MJ-1236],... gi\|150423201, gi... - gi\|254286774\|ref\|ZP_04961728.1\| pyruvate formate-lyase 1 activating enzyme [Vibrio cholerae AM-19226... gi\|153830545, gi... - gi\|153830545\|ref\|ZP_01983212.1\| pyruvate formate-lyase 1 activating enzyme [Vibrio cholerae 623-39],... gi\|153825235, gi... - gi\|153825235\|ref\|ZP_01977902.1\| pyruvate formate-lyase 1 activating enzyme [Vibrio cholerae MZO-2], ... gi\|254848956, gi... - gi\|75830397\|ref\|ZP_00759676.1\| COG1180: Pyruvate-formate lyase-activating enzyme [Vibrio cholerae MO... gi\|146316003, gi... - gi\|75827194\|ref\|ZP_00756629.1\| COG1180: Pyruvate-formate lyase-activating enzyme [Vibrio cholerae O3... gi\|9656400, gi\|1... - gi\|9656400\|gb\|AAF95017.1\| pyruvate formate-lyase 1 activating enzyme [Vibrio cholerae O1 biovar El T... gi\|116220415, gi... - gi\|75819694\|ref\|ZP_00749763.1\| COG1180: Pyruvate-formate lyase-activating enzyme [Vibrio cholerae V5... gi\|11256581 - pir\|\|C82145 pyruvate formate-lyase 1 activating enzyme VC1869 [imported] - Vibrio cholerae (strain N... gi\|121630492, gi... - gi\|75815877\|ref\|ZP_00746366.1\| COG1180: Pyruvate-formate lyase-activating enzyme [Vibrio cholerae V5... gi\|183012918, gi... - gi\|183179507\|ref\|ZP_02957718.1\| pyruvate formate-lyase 1 activating enzyme [Vibrio cholerae MZO-3], ... gi\|227081998, gi... - gi\|227081998\|ref\|YP_002810549.1\| pyruvate formate-lyase 1 activating enzyme [Vibrio cholerae M66-2],... gi\|121587313, gi... - gi\|121587313\|ref\|ZP_01677085.1\| pyruvate formate-lyase 1 activating enzyme [Vibrio cholerae 2740-80]... gi\|229508034, gi... - gi\|229508034\|ref\|ZP_04397539.1\| pyruvate formate-lyase activating enzyme [Vibrio cholerae BX 330286]...	193.0	[0..10]	[255..1]
gi\|117623083, gi... - gi\|117623083\|ref\|YP_851996.1\| pyruvate formate lyase-activating enzyme 1 [Escherichia coli APEC O1],...	192.0	[0..10]	[255..20]
gi\|205358099, gi... - gi\|205358099\|ref\|ZP_02575805.2\| pyruvate formate-lyase 1-activating enzyme [Salmonella enterica subs... gi\|62127127, gi\|... - gi\|62179494\|ref\|YP_215911.1\| pyruvate formate lyase activating enzyme 1 [Salmonella enterica subsp. ...	192.0	[0..10]	[255..47]
gi\|46914345, gi\|... - gi\|54309906\|ref\|YP_130926.1\| pyruvate formate lyase-activating enzyme 1 [Photobacterium profundum SS...	192.0	[0..10]	[255..1]
gi\|124498235, gi... - gi\|124531973\|ref\|ZP_01702032.1\| pyruvate formate-lyase activating enzyme [Escherichia coli B], gi\|12... gi\|238900160, gi... - gi\|238900160\|ref\|YP_002925956.1\| pyruvate formate lyase activating enzyme 1 [Escherichia coli BW2952... gi\|110804910, gi... - gi\|110804910\|ref\|YP_688430.1\| pyruvate formate lyase-activating enzyme 1 [Shigella flexneri 5 str. 8... gi\|218557807, gi... - gi\|218557807\|ref\|YP_002390720.1\| pyruvate formate lyase-activating enzyme 1 [Escherichia coli S88], ... gi\|242376717, gi... - gi\|251784444\|ref\|YP_002998748.1\| hypothetical protein B21_00913 [Escherichia coli BL21], gi\|24237671... gi\|218426306, gi... - gi\|218688742\|ref\|YP_002396954.1\| pyruvate formate lyase-activating enzyme 1 [Escherichia coli ED1a],... gi\|253977131, gi... - gi\|254287824\|ref\|YP_003053572.1\| pyruvate formate lyase activating enzyme 1 [Escherichia coli BL21(D... gi\|218694375, gi... - gi\|218694375\|ref\|YP_002402042.1\| pyruvate formate lyase-activating enzyme 1 [Escherichia coli 55989]... gi\|254161016, gi... - gi\|254161016\|ref\|YP_003044124.1\| pyruvate formate lyase activating enzyme 1 [Escherichia coli B str.... gi\|218700580, gi... - gi\|218700580\|ref\|YP_002408209.1\| pyruvate formate lyase-activating enzyme 1 [Escherichia coli IAI39]... gi\|254591501, gi... - gi\|254792101\|ref\|YP_003076938.1\| pyruvate formate lyase activating enzyme 1 [Escherichia coli O157:H... gi\|218431426, gi... - gi\|218704329\|ref\|YP_002411848.1\| pyruvate formate lyase-activating enzyme 1 [Escherichia coli UMN026... gi\|89107752, gi\|... - gi\|89107752\|ref\|AP_001532.1\| pyruvate formate lyase activating enzyme 1 [Escherichia coli str. K-12 ... gi\|15830239, gi\|... - gi\|15830239\|ref\|NP_309012.1\| pyruvate formate lyase-activating enzyme 1 [Escherichia coli O157:H7 st... gi\|110342691, gi... - gi\|110641099\|ref\|YP_668829.1\| pyruvate formate lyase-activating enzyme 1 [Escherichia coli 536], gi\|... gi\|82544640, gi\|... - gi\|82544640\|ref\|YP_408587.1\| pyruvate formate lyase-activating enzyme 1 [Shigella boydii Sb227], gi\|... PFLA_ECOL6 - Pyruvate formate-lyase 1-activating enzyme OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / ... gi\|56479766, gi\|... - gi\|56479766\|ref\|NP_706820.2\| pyruvate formate lyase-activating enzyme 1 [Shigella flexneri 2a str. 3... gi\|162138459 - gi\|162138459\|ref\|YP_539989.2\| pyruvate formate lyase-activating enzyme 1 [Escherichia coli UTI89] gi\|168752115, gi... - gi\|188013962\|gb\|EDU52084.1\| pyruvate formate-lyase 1-activating enzyme [Escherichia coli O157:H7 str... gi\|168756994, gi... - gi\|189355900\|gb\|EDU74319.1\| pyruvate formate-lyase 1-activating enzyme [Escherichia coli O157:H7 str... gi\|168762963, gi... - gi\|189366831\|gb\|EDU85247.1\| pyruvate formate-lyase 1-activating enzyme [Escherichia coli O157:H7 str... gi\|189361165, gi... - gi\|189361165\|gb\|EDU79584.1\| pyruvate formate-lyase 1-activating enzyme [Escherichia coli O157:H7 str... gi\|190907575, gi... - gi\|75240976\|ref\|ZP_00724865.1\| COG1180: Pyruvate-formate lyase-activating enzyme [Escherichia coli F... gi\|193064616, gi... - gi\|75257383\|ref\|ZP_00728899.1\| COG1180: Pyruvate-formate lyase-activating enzyme [Escherichia coli E... gi\|194413590, gi... - gi\|75210409\|ref\|ZP_00710565.1\| COG1180: Pyruvate-formate lyase-activating enzyme [Escherichia coli B... gi\|75234415, gi\|... - gi\|75234415\|ref\|ZP_00718776.1\| COG1180: Pyruvate-formate lyase-activating enzyme [Escherichia coli E... PFLA_ECOL6 - Pyruvate formate-lyase 1-activating enzyme OS=Escherichia coli O6 GN=pflA PE=3 SV=2 gi\|81241726, gi\|... - gi\|82777578\|ref\|YP_403927.1\| pyruvate formate lyase-activating enzyme 1 [Shigella dysenteriae Sd197]... gi\|188492165, gi... - gi\|75512058\|ref\|ZP_00734643.1\| COG1180: Pyruvate-formate lyase-activating enzyme [Escherichia coli 5... gi\|73854935, gi\|... - gi\|74311458\|ref\|YP_309877.1\| pyruvate formate lyase-activating enzyme 1 [Shigella sonnei Ss046], gi\|... gi\|208815370, gi... - gi\|208815370\|ref\|ZP_03256549.1\| pyruvate formate-lyase 1-activating enzyme [Escherichia coli O157:H7... gi\|208822382, gi... - gi\|208822382\|ref\|ZP_03262701.1\| pyruvate formate-lyase 1-activating enzyme [Escherichia coli O157:H7... gi\|209162241, gi... - gi\|209400841\|ref\|YP_002269574.1\| pyruvate formate-lyase 1-activating enzyme [Escherichia coli O157:H... gi\|209918152, gi... - gi\|209918152\|ref\|YP_002292236.1\| pyruvate formate lyase-activating enzyme 1 [Escherichia coli SE11],... gi\|75178295 - gi\|75178295\|ref\|ZP_00698349.1\| COG1180: Pyruvate-formate lyase-activating enzyme [Shigella boydii BS... gi\|215264099, gi... - gi\|215486027\|ref\|YP_002328458.1\| pyruvate formate lyase-activating enzyme 1 [Escherichia coli O127:H... gi\|157160424, gi... - gi\|75195090\|ref\|ZP_00705160.1\| COG1180: Pyruvate-formate lyase-activating enzyme [Escherichia coli H... gi\|217321082, gi... - gi\|217324861\|ref\|ZP_03440945.1\| pyruvate formate-lyase 1-activating enzyme [Escherichia coli O157:H7... gi\|83569141, gi\|... - gi\|83569141\|ref\|ZP_00920600.1\| COG1180: Pyruvate-formate lyase-activating enzyme [Shigella dysenteri... gi\|218548419, gi... - gi\|218548419\|ref\|YP_002382210.1\| pyruvate formate lyase-activating enzyme 1 [Escherichia fergusonii ... gi\|83585845, gi\|... - gi\|83585845\|ref\|ZP_00924485.1\| COG1180: Pyruvate-formate lyase-activating enzyme [Escherichia coli 1... gi\|218553488, gi... - gi\|218553488\|ref\|YP_002386401.1\| pyruvate formate lyase-activating enzyme 1 [Escherichia coli IAI1],... gi\|187768338, gi... - gi\|187768338\|gb\|EDU32182.1\| pyruvate formate-lyase 1-activating enzyme [Escherichia coli O157:H7 str... gi\|188998898, gi... - gi\|188998898\|gb\|EDU67884.1\| pyruvate formate-lyase 1-activating enzyme [Escherichia coli O157:H7 str... gi\|189372637, gi... - gi\|189372637\|gb\|EDU91053.1\| pyruvate formate-lyase 1-activating enzyme [Escherichia coli O157:H7 str... gi\|168801415, gi... - gi\|189376430\|gb\|EDU94846.1\| pyruvate formate-lyase 1-activating enzyme [Escherichia coli O157:H7 str... gi\|169755624, gi... - gi\|170020696\|ref\|YP_001725650.1\| pyruvate formate lyase-activating enzyme 1 [Escherichia coli ATCC 8... gi\|170080560, gi... - gi\|170080560\|ref\|YP_001729880.1\| pyruvate formate lyase activating enzyme 1 [Escherichia coli str. K... gi\|195939563 - gi\|195939563\|ref\|ZP_03084945.1\| pyruvate formate lyase-activating enzyme 1 [Escherichia coli O157:H7... gi\|208805965, gi... - gi\|208805965\|ref\|ZP_03248302.1\| pyruvate formate-lyase 1-activating enzyme [Escherichia coli O157:H7... EG10028 - pyruvate formate-lyase 1-activating enzyme; [formate-C-acetyltransferase 1]-activating enzyme; PFL a... gi\|12514065, gi\|... - gi\|15800763\|ref\|NP_286777.1\| pyruvate formate lyase-activating enzyme 1 [Escherichia coli O157:H7 ED... EG10028 - pyruvate formate-lyase 1-activating enzyme; [formate-C-acetyltransferase 1]-activating enzyme; PFL a... PFLA_SHIFL - Pyruvate formate-lyase 1-activating enzyme OS=Shigella flexneri GN=pflA PE=3 SV=2 PFLA_ECOLI - Pyruvate formate-lyase 1-activating enzyme (EC 1.97.1.4) (PFL-activating enzyme) (Formate-C-acetyltr... gi\|30040683, gi\|... - gi\|30062437\|ref\|NP_836608.1\| pyruvate formate lyase-activating enzyme 1 [Shigella flexneri 2a str. 2... PFLA_ECO57 - Pyruvate formate-lyase 1-activating enzyme OS=Escherichia coli O157:H7 GN=pflA PE=3 SV=2	191.0	[0..10]	[255..1]
gi\|206708164, gi... - gi\|207856361\|ref\|YP_002243012.1\| pyruvate formate lyase-activating enzyme 1 [Salmonella enterica sub... gi\|205271958, gi... - gi\|205352177\|ref\|YP_002225978.1\| pyruvate formate lyase-activating enzyme 1 [Salmonella enterica sub... gi\|16764330, gi\|... - gi\|16764330\|ref\|NP_459945.1\| pyruvate formate lyase-activating enzyme 1 [Salmonella typhimurium LT2]...	191.0	[0..10]	[255..29]
SO2913 - pyruvate formate-lyase 1 activating enzyme gi\|24374440, gi\|... - gi\|24374440\|ref\|NP_718483.1\| pyruvate formate lyase-activating enzyme 1 [Shewanella oneidensis MR-1]...	191.0	[0..10]	[255..1]

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Predicted Domain #1

Region A:
Residues: [1-255]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGHIWRNTAM SVIGRIHSFE SCGTVDGPGI RFITFFQGCL MRCLYCHNRD TWDTHGGKEV  60
   61 TVEDLMKEVV TYRHFMNASG GGVTASGGEA ILQAEFVRDW FRACKKEGIH TCLDTNGFVR 120
  121 RYDPVIDELL EVTDLVMLDL KQMNDEIHQN LVGVSNHRTL EFAKYLANKN VKVWIRYVVV 180
  181 PGWSDDDDSA HRLGEFTRDM GNVEKIELLP YHELGKHKWV AMGEEYKLDG VKPPKKETME 240
  241 RVKGILEQYG HKVMF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	25.30103
Match:	1r30A
Description:	The Crystal Structure of Biotin Synthase, an S-Adenosylmethionine-Dependent Radical Enzyme
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.85375915825216	bayes_pls_golite062009
transferase activity	0.885866547766734	bayes_pls_golite062009
oxidoreductase activity	0.497602428796508	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors	0.0354148694695802	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: