YRC Public Data Repository - Protein Structure Prediction

Protein:	EG12207
Organism:	Escherichia coli str. K-12 substr. MG1655
Length:	269 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for EG12207.

Description	E-value	Query Range	Subject Range
gi\|74311865, gi\|... - gi\|74311865\|ref\|YP_310284.1\| 23S rRNA methyltransferase A [Shigella sonnei Ss046], gi\|73855342\|gb\|AA...	241.0	[0..1]	[269..1]
gi\|190908016, gi... - gi\|191171686\|ref\|ZP_03033233.1\| ribosomal RNA large subunit methyltransferase A [Escherichia coli F1... gi\|110641939, gi... - gi\|110641939\|ref\|YP_669669.1\| 23S rRNA methyltransferase A [Escherichia coli 536], gi\|110343531\|gb\|A...	240.0	[0..1]	[269..1]
gi\|168765207, gi... - gi\|189364975\|gb\|EDU83391.1\| ribosomal RNA large subunit methyltransferase A [Escherichia coli O157:H... gi\|189372027, gi... - gi\|189372027\|gb\|EDU90443.1\| ribosomal RNA large subunit methyltransferase A [Escherichia coli O157:H... gi\|217328664, gi... - gi\|217328664\|ref\|ZP_03444745.1\| ribosomal RNA large subunit methyltransferase A [Escherichia coli O1... gi\|209767858, gi... - pir\|\|G85793 probable enzyme yebH [imported] - Escherichia coli (strain O157:H7, substrain EDL933), ... gi\|15802235, gi\|... - gi\|15802235\|ref\|NP_288258.1\| 23S rRNA methyltransferase A [Escherichia coli O157:H7 EDL933], gi\|1251... gi\|13361999, gi\|... - gi\|15831786\|ref\|NP_310559.1\| hypothetical protein ECs2532 [Escherichia coli O157:H7], gi\|13361999\|db... gi\|13361999, gi\|... - gi\|15831786\|ref\|NP_310559.1\| 23S rRNA methyltransferase A [Escherichia coli O157:H7 str. Sakai], gi\|...	240.0	[0..1]	[269..1]
gi\|24112788, gi\|... - gi\|24112788\|ref\|NP_707298.1\| 23S rRNA methyltransferase A [Shigella flexneri 2a str. 301], gi\|240517... gi\|110805384, gi... - gi\|110805384\|ref\|YP_688904.1\| 23S rRNA methyltransferase A [Shigella flexneri 5 str. 8401], gi\|11061... gi\|30041171, gi\|... - gi\|30062922\|ref\|NP_837093.1\| 23S rRNA methyltransferase A [Shigella flexneri 2a str. 2457T], gi\|3004... gi\|81245155, gi\|... - gi\|82543744\|ref\|YP_407691.1\| 23S rRNA methyltransferase A [Shigella boydii Sb227], gi\|81245155\|gb\|AB...	240.0	[0..1]	[269..1]
gi\|26108486, gi\|... - gi\|26248083\|ref\|NP_754123.1\| 23S rRNA methyltransferase A [Escherichia coli CFT073], gi\|26108486\|gb\|...	240.0	[0..1]	[269..1]
gi\|218365453, gi... - gi\|218558684\|ref\|YP_002391597.1\| 23S rRNA methyltransferase A [Escherichia coli S88], gi\|218365453\|e... gi\|115513105, gi... - gi\|117623981\|ref\|YP_852894.1\| 23S rRNA methyltransferase A [Escherichia coli APEC O1], gi\|115513105\|... gi\|237705772, gi... - gi\|237705772\|ref\|ZP_04536253.1\| ribosomal RNA large subunit methyltransferase A [Escherichia sp. 3_2... gi\|91211041, gi\|... - gi\|91211041\|ref\|YP_541027.1\| 23S rRNA methyltransferase A [Escherichia coli UTI89], gi\|91072615\|gb\|A...	240.0	[0..1]	[269..1]
gi\|47168537, gi\|... - gi\|47168537\|pdb\|1P91\|B Chain B, Crystal Structure Of Rlma(I) Enzyme: 23s Rrna N1-G745 Methyltransfer...	235.0	[0..1]	[269..1]
gi\|28898934, gi\|... - gi\|28898934\|ref\|NP_798539.1\| 23S rRNA methyltransferase A [Vibrio parahaemolyticus RIMD 2210633], gi... gi\|28807153 - gi\|28807153\|dbj\|BAC60423.1\| rRNA (guanine-N1-)-methyltransferase [Vibrio parahaemolyticus RIMD 22106... gi\|153838701, gi... - gi\|153838701\|ref\|ZP_01991368.1\| ribosomal RNA large subunit methyltransferase A (rRNA(guanine-N(1)-)...	229.0	[0..1]	[268..1]
gi\|85833838, gi\|... - gi\|86148355\|ref\|ZP_01066648.1\| rRNA (guanine-N1-)-methyltransferase [Vibrio sp. MED222], gi\|85833838...	227.0	[0..1]	[268..1]
gi\|84376018, gi\|... - gi\|84393302\|ref\|ZP_00992062.1\| rRNA (guanine-N1-)-methyltransferase [Vibrio splendidus 12B01], gi\|84...	227.0	[0..1]	[268..1]

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Predicted Domain #1

Region A:
Residues: [1-269]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFSCPLCHQ PLSREKNSYI CPQRHQFDMA KEGYVNLLPV QHKRSRDPGD SAEMMQARRA  60
   61 FLDAGHYQPL RDAIVAQLRE RLDDKATAVL DIGCGEGYYT HAFADALPEI TTFGLDVSKV 120
  121 AIKAAAKRYP QVTFCVASSH RLPFSDTSMD AIIRIYAPCK AEELARVVKP GGWVITATPG 180
  181 PRHLMELKGL IYNEVHLHAP HAEQLEGFTL QQSAELCYPM RLRGDEAVAL LQMTPFAWRA 240
  241 KPEVWQTLAA KEVFDCQTDF NIHLWQRSY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	64.0
Match:	1p91A
Description:	Crystal Structure of RlmA(I) enzyme: 23S rRNA n1-G745 methyltransferase (NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET ER19)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
methyltransferase activity	4.15445027778357	bayes_pls_golite062009
rRNA methyltransferase activity	4.09362182773099	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	4.07153733729662	bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity	3.39429041855776	bayes_pls_golite062009
RNA methyltransferase activity	3.07428840534971	bayes_pls_golite062009
N-methyltransferase activity	3.0539218951403	bayes_pls_golite062009
protein methyltransferase activity	3.01384869242051	bayes_pls_golite062009
transferase activity	2.22303238506686	bayes_pls_golite062009
histone methyltransferase activity	1.90505369820945	bayes_pls_golite062009
rRNA (adenine) methyltransferase activity	1.83964463328968	bayes_pls_golite062009
rRNA (adenine-N6,N6-)-dimethyltransferase activity	1.75675289134467	bayes_pls_golite062009
DNA-methyltransferase activity	1.63765148226572	bayes_pls_golite062009
protein-arginine N-methyltransferase activity	1.6030970825293	bayes_pls_golite062009
arginine N-methyltransferase activity	1.6030970825293	bayes_pls_golite062009
catalytic activity	1.25333584501255	bayes_pls_golite062009
tRNA methyltransferase activity	1.12859857407629	bayes_pls_golite062009
rRNA (guanine) methyltransferase activity	1.10713374933008	bayes_pls_golite062009
histone-arginine N-methyltransferase activity	1.05897361334523	bayes_pls_golite062009
site-specific DNA-methyltransferase (adenine-specific) activity	0.703178429468566	bayes_pls_golite062009
protein-arginine omega-N monomethyltransferase activity	0.639377525568296	bayes_pls_golite062009
rRNA (guanine-N2-)-methyltransferase activity	0.427131446117391	bayes_pls_golite062009
rRNA (cytosine) methyltransferase activity	0.346042596102079	bayes_pls_golite062009
O-methyltransferase activity	0.250946859465502	bayes_pls_golite062009
protein-arginine omega-N asymmetric methyltransferase activity	0.130104080746388	bayes_pls_golite062009
histone methyltransferase activity (H4-R3 specific)	0.130042730841119	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: