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View Structure Prediction Details

Protein: RNH2A_YEAST
Organism: Saccharomyces cerevisiae S288c
Length: 307 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RNH2A_YEAST.

Description E-value Query
Range		 Subject
Range
RNH201 - Ribonuclease H2 catalytic subunit, removes RNA primers during Okazaki fragment synthesis; homolog of...
RNH2A_YEAST - Ribonuclease H2 subunit A OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RNH201 PE=1 SV...
gi|207341690 - gi|207341690|gb|EDZ69676.1| YNL072Wp-like protein [Saccharomyces cerevisiae AWRI1631]
gi|190409061 - gi|190409061|gb|EDV12326.1| ribonuclease HI 35 large subunit [Saccharomyces cerevisiae RM11-1a]
 4.0E-91 [1..307] [1..307]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 1.0E-79 [5..302] [398..691]
RNH2A_ARATH - Ribonuclease H2 subunit A OS=Arabidopsis thaliana GN=At2g25100 PE=2 SV=2
 3.0E-74 [23..304] [2..276]
RNHL_MOUSE - (Q9CWY8) Ribonuclease HI large subunit (EC 3.1.26.-) (RNase HI large subunit)
 1.0E-67 [18..274] [16..262]
RNH2A_SCHPO - Ribonuclease H2 subunit A OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=rnh201 PE=3 SV=1
SPAC4G9.02 - ribonuclease H2 complex subunit
 6.0E-67 [2..283] [35..311]
RNH2A_NEUCR, RNH... - (Q9P5X8) Probable ribonuclease HI large subunit (EC 3.1.26.4) (RNase HI large subunit) (RNase H(35))...
RNH2A_NEUCR - Ribonuclease H2 subunit A OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 12...
 4.0E-65 [2..267] [12..275]
CG13690-PA - This gene is referred to in FlyBase by the symbol Dmel\CG13690 (CG13690, FBgn0031252). It is a prote...
gi|220951678 - gi|220951678|gb|ACL88382.1| CG13690-PA [synthetic construct]
 2.0E-63 [8..276] [48..307]
gi|19168694, gi|... - gi|19173027|ref|NP_597578.1| BELONGS TO THE RIBONUCLEASE HII FAMILY [Encephalitozoon cuniculi GB-M1]...
gi|19173027 - gi|19173027|ref|NP_597578.1| BELONGS TO THE RIBONUCLEASE HII FAMILY [Encephalitozoon cuniculi GB-M1]
 9.0E-56 [29..275] [13..239]

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Predicted Domain #1
Region A:
Residues: [1-205] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVPPTVEASL ESPYTKSYFS PVPSALLEQN DSPIIMGIDE AGRGPVLGPM VYAVAYSTQK  60
   61 YQDETIIPNY EFDDSKKLTD PIRRMLFSKI YQDNEELTQI GYATTCITPL DISRGMSKFP 120
  121 PTRNYNLNEQ AHDVTMALID GVIKQNVKLS HVYVDTVGPP ASYQKKLEQR FPGVKFTVAK 180
  181 KADSLYCMVS VASVVAKVTR DILVE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 234.70927
Match: 1io2A_
Description: Class II ribonuclease H (RNase HII)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ribonuclease H activity 8.30690368719529 bayes_pls_golite062009
ribonuclease activity 4.81599779544001 bayes_pls_golite062009
exoribonuclease activity 3.01417328311605 bayes_pls_golite062009
exoribonuclease activity, producing 5'-phosphomonoesters 2.89077854960958 bayes_pls_golite062009
exonuclease activity 2.86892175148145 bayes_pls_golite062009
nuclease activity 2.84202779131927 bayes_pls_golite062009
hydrolase activity 2.78602644579272 bayes_pls_golite062009
DNA polymerase activity 2.75375255857158 bayes_pls_golite062009
DNA-directed DNA polymerase activity 2.66279543366449 bayes_pls_golite062009
endonuclease activity 2.63074055051349 bayes_pls_golite062009
endoribonuclease activity 2.59247838057313 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 2.57498413015114 bayes_pls_golite062009
3'-5'-exoribonuclease activity 2.49957333962564 bayes_pls_golite062009
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 1.94077739152313 bayes_pls_golite062009
deoxyribonuclease activity 1.87431870698721 bayes_pls_golite062009
catalytic activity 1.25233849524628 bayes_pls_golite062009
nucleotidyltransferase activity 1.12401205867904 bayes_pls_golite062009
nucleic acid binding 1.12235348738959 bayes_pls_golite062009
transcription regulator activity 1.10433412699603 bayes_pls_golite062009
3'-5' exonuclease activity 0.86862629020506 bayes_pls_golite062009
exodeoxyribonuclease activity, producing 5'-phosphomonoesters 0.782108781904855 bayes_pls_golite062009
exodeoxyribonuclease activity 0.77421125364834 bayes_pls_golite062009
binding 0.762139256580538 bayes_pls_golite062009
DNA binding 0.710663468386339 bayes_pls_golite062009
endoribonuclease activity, producing 5'-phosphomonoesters 0.708753843279937 bayes_pls_golite062009
endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 0.598360955770972 bayes_pls_golite062009
endodeoxyribonuclease activity 0.48776342704945 bayes_pls_golite062009
transcription factor activity 0.332903382446869 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [206-307] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SLKRDPDEIL GSGYPSDPKT VAWLKRNQTS LMGWPANMVR FSWQTCQTLL DDASKNSIPI  60
   61 KWEEQYMDSR KNAAQKTKQL QLQMVAKPVR RKRLRTLDNW YR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 234.70927
Match: 1io2A_
Description: Class II ribonuclease H (RNase HII)
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle