| Protein: | NPC1_YEAST |
| Organism: | Saccharomyces cerevisiae S288c |
| Length: | 1170 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NPC1_YEAST.
| Description | E-value | Query Range |
Subject Range |
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0.0 | [1..1170] | [8..1263] |
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0.0 | [1..1170] | [8..1265] |
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0.0 | [2..1170] | [9..1264] |
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0.0 | [1..1170] | [8..1263] |
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0.0 | [1..1170] | [8..1264] |
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0.0 | [1..1170] | [1..1170] |
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0.0 | [2..1170] | [9..1264] |
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0.0 | [1..1170] | [8..1264] |
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Region A: Residues: [1-284] |
1 11 21 31 41 51
| | | | | |
1 MNVLWIIALV GQLMRLVQGT ATCAMYGNCG KKSVFGNELP CPVPRSFEPP VLSDETSKLL 60
61 VEVCGEEWKE VRYACCTKDQ VVALRDNLQK AQPLISSCPA CLKNFNNLFC HFTCAADQGR 120
121 FVNITKVEKS KEDKDIVAEL DVFMNSSWAS EFYDSCKNIK FSATNGYAMD LIGGGAKNYS 180
181 QFLKFLGDAK PMLGGSPFQI NYKYDLANEE KEWQEFNDEV YACDDAQYKC ACSDCQESCP 240
241 HLKPLKDGVC KVGPLPCFSL SVLIFYTICA LFAFMWYYLC KRKK
|
| Detection Method: |  |
Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.
Found no structure predictions for this domain.
|
Region A: Residues: [285-391] |
1 11 21 31 41 51
| | | | | |
1 NGAMIVDDDI VPESGSLDES ETNVFESFNN ETNFFNGKLA NLFTKVGQFS VENPYKILIT 60
61 TVFSIFVFSF IIFQYATLET DPINLWVSKN SEKFKEKEYF DDNFGPF
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|
Region B: Residues: [490-547] |
1 11 21 31 41 51
| | | | | |
1 TNLLFSDDDI LNAHAFVVTL LLTNHTQSAN RWEERLEEYL LDLKVPEGLR ISFNTEIS
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Region C: Residues: [778-886] |
1 11 21 31 41 51
| | | | | |
1 LAVPQDSYLV DYFKDVYSFL NVGPPVYMVV KNLDLTKRQN QQKICGKFTT CERDSLANVL 60
61 EQERHRSTIT EPLANWLDDY FMFLNPQNDQ CCRLKKGTDE VCPPSFPSR
|
| Detection Method: | |
| Confidence: | 191.0103 |
| Match: | 1oy6A_ |
| Description: | Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains; Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains; Multidrug efflux transporter AcrB transmembrane domain |
Matching Structure (courtesy of the PDB): |
|
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Region A: Residues: [392-489] |
1 11 21 31 41 51
| | | | | |
1 YRTEQIFVVN ETGPVLSYET LHWWFDVENF ITEELQSSEN IGYQDLCFRP TEDSTCVIES 60
61 FTQYFQGALP NKDSWKRELQ ECGKFPVNCL PTFQQPLK
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Region B: Residues: [548-777] |
1 11 21 31 41 51
| | | | | |
1 LEKELNNNND ISTVAISYLM MFLYATWALR RKDGKTRLLL GISGLLIVLA SIVCAAGFLT 60
61 LFGLKSTLII AEVIPFLILA IGIDNIFLIT HEYDRNCEQK PEYSIDQKII SAIGRMSPSI 120
121 LMSLLCQTGC FLIAAFVTMP AVHNFAIYST VSVIFNGVLQ LTAYVSILSL YEKRSNYKQI 180
181 TGNEETKESF LKTFYFKMLT QKRLIIIIFS AWFFTSLVFL PEIQFGLDQT
|
| Detection Method: | |
| Confidence: | 191.0103 |
| Match: | 1oy6A_ |
| Description: | Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains; Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains; Multidrug efflux transporter AcrB transmembrane domain |
| Matching Structure (courtesy of the PDB): |
|
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Region A: Residues: [887-977] |
1 11 21 31 41 51
| | | | | |
1 RCETCFQQGS WNYNMSGFPE GKDFMEYLSI WINAPSDPCP LGGRAPYSTA LVYNETSVSA 60
61 SVFRTAHHPL RSQKDFIQAY SDGVRISSSF P
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| Detection Method: | |
Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.
| MCM Score |
SCOP Match |
SCOP Description | ||
| View | Download | 0.312 | d.93.1 | SH2 domain |
| View | Download | 0.692 | d.58.4 | Dimeric alpha+beta barrel |
| View | Download | 0.441 | d.110.1 | Profilin (actin-binding protein) |
| View | Download | 0.626 | d.110.4 | SNARE-like |
| View | Download | 0.673 | d.31.1 | Cdc48 domain 2-like |
| View | Download | 0.308 | a.39.2 | Insect pheromon/odorant-binding proteins |
| View | Download | 0.300 | d.88.1 | SRF-like |
| View | Download | 0.293 | a.74.1 | Cyclin-like |
| View | Download | 0.279 | a.71.1 | Endoplasmic reticulum protein ERP29, C-domain |
| View | Download | 0.276 | d.49.1 | Signal recognition particle alu RNA binding heterodimer, SRP9/14 |
| View | Download | 0.270 | a.80.1 | DNA polymerase III clamp loader subunits, C-terminal domain |
| View | Download | 0.267 | d.238.1 | Hypothetical protein TM0875 |
| View | Download | 0.256 | d.15.6 | Superantigen toxins, C-terminal domain |
| View | Download | 0.241 | a.49.1 | C-terminal domain of B transposition protein |
| View | Download | 0.241 | d.50.1 | dsRNA-binding domain-like |
| View | Download | 0.236 | a.24.7 | FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP) |
| View | Download | 0.231 | d.93.1 | SH2 domain |
| View | Download | 0.222 | d.93.1 | SH2 domain |
| View | Download | 0.208 | a.64.1 | Saposin |
| View | Download | 0.203 | g.52.1 | Inhibitor of apoptosis (IAP) repeat |
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Region A: Residues: [978-1170] |
1 11 21 31 41 51
| | | | | |
1 ELDMFAYSPF YIFFVQYQTL GPLTLKLIGS AIILIFFISS VFLQNIRSSF LLALVVTMII 60
61 VDIGALMALL GISLNAVSLV NLIICVGLGV EFCVHIVRSF TVVPSETKKD ANSRVLYSLN 120
121 TIGESVIKGI TLTKFIGVCV LAFAQSKIFD VFYFRMWFTL IIVAALHALL FLPALLSLFG 180
181 GESYRDDSIE AED
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| Detection Method: | |
Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.
Found no structure predictions for this domain.
