YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|16410456, gi\|...
Organism:	Listeria monocytogenes
Length:	544 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|16410456, gi|....

Description	E-value	Query Range	Subject Range
gi\|254880079 - gi\|254880079\|ref\|ZP_05252789.1\| dihydrolipoamide acetyltransferase [Listeria monocytogenes FSL J2-07... gi\|254853059 - gi\|254853059\|ref\|ZP_05242407.1\| dihydrolipoamide acetyltransferase [Listeria monocytogenes FSL R2-50... gi\|46907286, gi\|... - gi\|46907286\|ref\|YP_013675.1\| dihydrolipoamide acetyltransferase [Listeria monocytogenes str. 4b F236... gi\|47018693, gi\|... - gi\|47092946\|ref\|ZP_00230727.1\| dihydrolipoamide acetyltransferase [Listeria monocytogenes str. 4b H7... gi\|153166389, gi... - gi\|153166389\|ref\|ZP_01926975.1\| dihydrolipoamide acetyltransferase [Listeria monocytogenes FSL N1-01... gi\|254933398, gi... - gi\|254933398\|ref\|ZP_05266757.1\| dihydrolipoamide acetyltransferase [Listeria monocytogenes HPB2262],... gi\|226223672, gi... - gi\|226223672\|ref\|YP_002757779.1\| pyruvate dehydrogenase (dihydrolipoamide acetyltransferase E2 subun...	494.0	[0..1]	[544..1]
gi\|254898773, gi... - gi\|254898773\|ref\|ZP_05258697.1\| dihydrolipoamide acetyltransferase [Listeria monocytogenes J0161], g... gi\|127765847, gi... - gi\|254911738\|ref\|ZP_05261750.1\| dihydrolipoamide acetyltransferase [Listeria monocytogenes J2818], g... gi\|153195851, gi... - gi\|254830177\|ref\|ZP_05234832.1\| dihydrolipoamide acetyltransferase [Listeria monocytogenes 10403S], ... gi\|47096143, gi\|... - gi\|47096143\|ref\|ZP_00233743.1\| dihydrolipoamide acetyltransferase [Listeria monocytogenes str. 1/2a ... gi\|153179173, gi... - gi\|254936064\|ref\|ZP_05267761.1\| dihydrolipoamide acetyltransferase [Listeria monocytogenes F6900], g...	490.0	[0..1]	[544..1]
gi\|16800115 - gi\|16800115\|ref\|NP_470383.1\| dihydrolipoamide acetyltransferase [Listeria innocua Clip11262] gi\|16413505, gi\|... - pir\|\|AE1563 pyruvate dehydrogenase (dihydrolipoamide acetyltransferase E2 chain) homolog pdhC [impor...	489.0	[0..1]	[544..1]
gi\|84690477, gi\|... - gi\|84704043\|ref\|ZP_01017871.1\| dihydrolipoamide acetyltransferase [Parvularcula bermudensis HTCC2503...	473.0	[0..3]	[544..2]
gi\|89068137, gi\|... - gi\|89068137\|ref\|ZP_01155554.1\| dihydrolipoamide acetyltransferase [Oceanicola granulosus HTCC2516], ...	466.0	[0..1]	[544..1]
gi\|114707322, gi... - gi\|114707322\|ref\|ZP_01440219.1\| dihydrolipoamide acetyltransferase [Fulvimarina pelagi HTCC2506], gi...	466.0	[0..1]	[544..1]
gi\|97897, gi\|228023 - gi\|97897\|pir\|\|S16989 dihydrolipoamide S-acetyltransferase (EC 2.3.1.12) - Enterococcus faecalis, gi\|...	459.0	[0..1]	[543..1]
gi\|227518618, gi... - gi\|227518618\|ref\|ZP_03948667.1\| dihydrolipoamide acetyltransferase [Enterococcus faecalis TX0104], g... gi\|29375922, gi\|... - gi\|29375922\|ref\|NP_815076.1\| dihydrolipoamide acetyltransferase [Enterococcus faecalis V583], gi\|293...	458.0	[0..1]	[543..1]
gi\|77464544, gi\|... - gi\|77464544\|ref\|YP_354048.1\| dihydrolipoamide acetyltransferase [Rhodobacter sphaeroides 2.4.1], gi\|...	458.0	[0..1]	[544..2]
gi\|68194093, gi\|... - gi\|69249706\|ref\|ZP_00605033.1\| Dihydrolipoamide S-succinyltransferase [Enterococcus faecium DO], gi\|... gi\|48823807 - ref\|ZP_00285290.1\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltran...	457.0	[0..1]	[543..1]

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Predicted Domain #1

Region A:
Residues: [1-110]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAYSFKLPDI GEGIHEGEIV KWFVQPGDKI EEDESLFEVQ NDKSVEEITS PVSGTIKEIK  60
   61 VAEGTVATVG QVLVTFDGVE GHEDDAEEES AAPKAESTES TPAPAQASGK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	15.69897
Match:	1labA
Description:	THREE-DIMENSIONAL STRUCTURE OF THE LIPOYL DOMAIN FROM BACILLUS STEAROTHERMOPHILUS PYRUVATE DEHYDROGENASE MULTIENZYME COMPLEX
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
dihydrolipoyllysine-residue acetyltransferase activity	7.74877411346968	bayes_pls_golite062009
S-acetyltransferase activity	7.59642806209362	bayes_pls_golite062009
dihydrolipoamide S-acyltransferase activity	7.45508609960612	bayes_pls_golite062009
pyruvate dehydrogenase activity	7.05950875585975	bayes_pls_golite062009
S-acyltransferase activity	5.24395351180663	bayes_pls_golite062009
acetyltransferase activity	3.55333192628786	bayes_pls_golite062009
acetyl-CoA carboxylase activity	3.31123635155865	bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups	2.83081843426182	bayes_pls_golite062009
CoA carboxylase activity	2.82233689048595	bayes_pls_golite062009
acyltransferase activity	2.79754636323803	bayes_pls_golite062009
ligase activity, forming carbon-carbon bonds	2.53708026587542	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	2.22092493760605	bayes_pls_golite062009
catalytic activity	1.39099902011318	bayes_pls_golite062009
binding	0.988780943163898	bayes_pls_golite062009
transferase activity, transferring acyl groups	0.629490807878017	bayes_pls_golite062009
ligase activity	0.56894584941056	bayes_pls_golite062009
aminomethyltransferase activity	0.377624262164477	bayes_pls_golite062009
protein binding	0.273657523907432	bayes_pls_golite062009
glycine dehydrogenase (decarboxylating) activity	0.0222922933292004	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor	0.0222922933292004	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [111-318]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GIFEFKLPDI GEGIHEGEIV KWFIQPGDKV EEDQSIFEVQ NDKSVEEITS PVDGTVKDIL  60
   61 VSEGTVATVG QVLVTFEGDF EGEASHESTP ESPAEDAALA NNDATSAPAT GGNGTPSSKK 120
  121 DPNGLVIAMP SVRKYAREKG VNIAEVAGSG KNNRVVKADI DAFLNGEQPA AATTTAQTEE 180
  181 KAAAPKAEKA AGKQPVASSD AYPETREK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	23.154902
Match:	1zy8K
Description:	The crystal structure of dihydrolipoamide dehydrogenase and dihydrolipoamide dehydrogenase-binding protein (didomain) subcomplex of human pyruvate dehydrogenase complex.
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [319-544]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LTPTRRAIAK AMVNSKHTAP HVTLMDEIEV TALMAHRKRF KEVAAEKGIK LTFLPYMVKA  60
   61 LVATLRDFPV LNTTLDDATE ELVYKHYFNV GIAADTDHGL YVPVIKNADK KSVFQISDEI 120
  121 NELAGKARDG KLTADEMRHG SATISNIGSA GGQWFTPVIN YPEVAILGVG RIAQKPIVKD 180
  181 GEIVAAPVLA LSLSFDHRVI DGATAQKAMN NIKRLLNDPE LLLMEV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	83.0
Match:	1b5sA
Description:	Dihydrolipoamide acetyltransferase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
S-succinyltransferase activity	10.0778678835755	bayes_pls_golite062009
dihydrolipoyllysine-residue succinyltransferase activity	10.0778678835755	bayes_pls_golite062009
dihydrolipoyllysine-residue acetyltransferase activity	9.65061123545754	bayes_pls_golite062009
dihydrolipoamide S-acyltransferase activity	9.64995677986911	bayes_pls_golite062009
S-acetyltransferase activity	9.49696044977584	bayes_pls_golite062009
S-acyltransferase activity	8.45313874919036	bayes_pls_golite062009
pyruvate dehydrogenase activity	8.17557182322815	bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups	6.86215901871647	bayes_pls_golite062009
acyltransferase activity	6.83977352892719	bayes_pls_golite062009
succinyltransferase activity	6.58826720904067	bayes_pls_golite062009
pyruvate dehydrogenase (acetyl-transferring) activity	6.40483178382327	bayes_pls_golite062009
acetyltransferase activity	6.08159176722072	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	5.93985773477717	bayes_pls_golite062009
transferase activity, transferring acyl groups	4.60481199262496	bayes_pls_golite062009
alpha-ketoacid dehydrogenase activity	4.42757758312016	bayes_pls_golite062009
carnitine O-acyltransferase activity	2.87366177129153	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	2.54513901872655	bayes_pls_golite062009
catalytic activity	1.51562638409295	bayes_pls_golite062009
O-acyltransferase activity	1.33852311685118	bayes_pls_golite062009
O-palmitoyltransferase activity	1.22729402619659	bayes_pls_golite062009
carnitine O-palmitoyltransferase activity	1.22729402619659	bayes_pls_golite062009
transferase activity	1.08341671157927	bayes_pls_golite062009
carnitine O-acetyltransferase activity	1.00868366840715	bayes_pls_golite062009
binding	0.801074244553007	bayes_pls_golite062009
O-acetyltransferase activity	0.54660034926676	bayes_pls_golite062009
protein binding	0.00454070917775817	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: