YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|16412035, gi\|...
Organism:	Listeria monocytogenes
Length:	428 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|16412035, gi|....

Description	E-value	Query Range	Subject Range
gi\|47014679, gi\|... - gi\|47096969\|ref\|ZP_00234545.1\| homoserine dehydrogenase [Listeria monocytogenes str. 1/2a F6854], gi... gi\|126942388, gi... - gi\|254900314\|ref\|ZP_05260238.1\| homoserine dehydrogenase [Listeria monocytogenes J0161], gi\|15318487... gi\|153180634, gi... - gi\|254937828\|ref\|ZP_05269525.1\| homoserine dehydrogenase [Listeria monocytogenes F6900], gi\|15318063... gi\|153192203, gi... - gi\|254913447\|ref\|ZP_05263459.1\| homoserine dehydrogenase [Listeria monocytogenes J2818], gi\|15319220...	446.0	[0..1]	[428..1]
gi\|16801752 - gi\|16801752\|ref\|NP_472020.1\| homoserine dehydrogenase [Listeria innocua Clip11262] gi\|16415227, gi\|... - pir\|\|AE1768 homoserine dehydrogenase homolog hom [imported] - Listeria innocua (strain Clip11262), g...	446.0	[0..1]	[428..1]
gi\|254825330 - gi\|254825330\|ref\|ZP_05230331.1\| homoserine dehydrogenase [Listeria monocytogenes FSL J1-194] gi\|225877557, gi... - gi\|226225095\|ref\|YP_002759202.1\| homoserine dehydrogenase [Listeria monocytogenes Clip81459], gi\|225... gi\|254879127 - gi\|254879127\|ref\|ZP_05251837.1\| homoserine dehydrogenase [Listeria monocytogenes FSL J2-071] gi\|254853924 - gi\|254853924\|ref\|ZP_05243272.1\| homoserine dehydrogenase [Listeria monocytogenes FSL R2-503] gi\|255519757 - gi\|255519757\|ref\|ZP_05386994.1\| homoserine dehydrogenase [Listeria monocytogenes FSL J1-175] gi\|254993790 - gi\|254993790\|ref\|ZP_05275980.1\| homoserine dehydrogenase [Listeria monocytogenes FSL J2-064] gi\|46908719, gi\|... - gi\|46908719\|ref\|YP_015108.1\| homoserine dehydrogenase [Listeria monocytogenes str. 4b F2365], gi\|468... gi\|47017748, gi\|... - gi\|47093874\|ref\|ZP_00231616.1\| homoserine dehydrogenase [Listeria monocytogenes str. 4b H7858], gi\|4... gi\|217963349, gi... - gi\|217963349\|ref\|YP_002349027.1\| homoserine dehydrogenase (HDH) [Listeria monocytogenes HCC23], gi\|2... gi\|133726213, gi... - gi\|254872237\|ref\|ZP_05244947.1\| homoserine dehydrogenase [Listeria monocytogenes FSL N1-017], gi\|153... gi\|153204131, gi... - gi\|254932211\|ref\|ZP_05265570.1\| homoserine dehydrogenase [Listeria monocytogenes HPB2262], gi\|153204...	444.0	[0..1]	[428..1]
gi\|134051728, gi... - gi\|88945053\|ref\|ZP_01148274.1\| Homoserine dehydrogenase [Desulfotomaculum reducens MI-1], gi\|8892540...	435.0	[0..1]	[428..1]
gi\|113868242, gi... - gi\|113868242\|ref\|YP_726731.1\| homoserine dehydrogenase [Ralstonia eutropha H16], gi\|113527018\|emb\|CA...	430.0	[0..2]	[427..1]
gi\|94310904, gi\|... - gi\|94310904\|ref\|YP_584114.1\| homoserine dehydrogenase [Ralstonia metallidurans CH34], gi\|93354756\|gb...	429.0	[0..2]	[427..1]
gi\|89333557, gi\|... - gi\|89894109\|ref\|YP_517596.1\| homoserine dehydrogenase [Desulfitobacterium hafniense Y51], gi\|8933355...	429.0	[0..1]	[427..1]
gi\|46121076, gi\|... - gi\|91775401\|ref\|YP_545157.1\| homoserine dehydrogenase [Methylobacillus flagellatus KT], gi\|91775257\|...	429.0	[0..2]	[427..1]
gi\|146274033, gi... - gi\|98662917\|dbj\|GAA00328.1\| unnamed protein product [Pelotomaculum thermopropionicum SI], gi\|1476779...	428.0	[0..1]	[428..1]
gi\|53761449, gi\|... - gi\|73541681\|ref\|YP_296201.1\| homoserine dehydrogenase [Ralstonia eutropha JMP134], gi\|72119094\|gb\|AA...	428.0	[0..2]	[427..1]

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Predicted Domain #1

Region A:
Residues: [1-322]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEAKLQVGVL GFGTVGSGVI HILEEHQEKI SQVTGYNISV KKVLVRDLEK NRRYETKGFE  60
   61 LTTNPSDVLD DPEIAVVVEV MGSITTAREY ILQALKAGKH VVTANKDLIA LHGDELVAVA 120
  121 QANNCDLFYE ASVAGGIPIL RTIVNSLAAD KIQKVMGIVN GTTNFMLTKM TTEKKSYEDV 180
  181 LAEAQALGFA ESDPTNDVDG IDAARKMVIM TRLAFGMNVN LDNVETNGIR GISPEDIEVA 240
  241 YQLGYKIKLV GTAEETNGTV NVNVGPVLLP KAHPLAGVNY ENNAVFVTGA AVGETMFYGP 300
  301 GAGELPTATS VVSDLITVAK NS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	39.30103
Match:	1q7gA
Description:	Homoserine Dehydrogenase in complex with suicide inhibitor complex NAD-5-hydroxy-4-Oxonorvaline
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
aspartate-semialdehyde dehydrogenase activity	3.92511214237139	bayes_pls_golite062009
catalytic activity	2.91887313269429	bayes_pls_golite062009
oxidoreductase activity	2.86254373278283	bayes_pls_golite062009
dihydrodipicolinate reductase activity	1.71989205356835	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	1.19591951564949	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	1.07932840802619	bayes_pls_golite062009
ketol-acid reductoisomerase activity	0.57325534211306	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	0.23458869447046	bayes_pls_golite062009
N-acetyl-gamma-glutamyl-phosphate reductase activity	0.22364954992375	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	0.22262673350502	bayes_pls_golite062009
glyceraldehyde-3-phosphate dehydrogenase activity	0.0876163188309598	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [323-428]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RLGTNGNAFN SYKHETKHTP KEQVFSKYYL RLTMDDKTGT FLKLTQIFAE AGVGFDKILQ  60
   61 QPYDDFTATV VIVTHSTSQA QLEQAIARVK DEPEMQMLAK YSVVEG

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	3.08
Match:	2fgcA
Description:	Crystal structure of Acetolactate synthase- small subunit from Thermotoga maritima
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
acetolactate synthase activity	4.99852139046544	bayes_pls_golite062009
transferase activity, transferring aldehyde or ketonic groups	4.23792329132648	bayes_pls_golite062009
catalytic activity	0.992873814931369	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: