YRC Public Data Repository - Protein Structure Prediction

Protein:	COAD_YEAST
Organism:	Saccharomyces cerevisiae S288c
Length:	305 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for COAD_YEAST.

Description	E-value	Query Range	Subject Range
gi\|151943549 - gi\|151943549\|gb\|EDN61860.1\| conserved protein [Saccharomyces cerevisiae YJM789] CAB4 - Probable pantetheine-phosphate adenylyltransferase (PPAT), which catalyzes the fourth step in the bi... COAD_YEAST - Phosphopantetheine adenylyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=C...	8.0E-83	[1..305]	[1..305]
HLDE_HAEIN - Bifunctional protein hldE OS=Haemophilus influenzae GN=hldE PE=3 SV=1 HLDE_HAEIN - Bifunctional protein HldE OS=Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) GN=h...	4.0E-55	[21..264]	[217..468]
HLDE_SALTI - Bifunctional protein HldE OS=Salmonella typhi GN=hldE PE=3 SV=1 HLDE_SALPB - Bifunctional protein hldE OS=Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) GN=hldE PE=3 SV=1 HLDE_SALTY - Bifunctional protein HldE OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=hldE PE... gi\|167551884, gi... - gi\|205323340\|gb\|EDZ11179.1\| bifunctional protein HldE [Salmonella enterica subsp. enterica serovar S... gi\|205331168, gi... - gi\|205331168\|gb\|EDZ17932.1\| bifunctional protein HldE [Salmonella enterica subsp. enterica serovar 4... gi\|205333814, gi... - gi\|205333814\|gb\|EDZ20578.1\| bifunctional protein HldE [Salmonella enterica subsp. enterica serovar K... gi\|29143461, gi\|... - gi\|29143461\|ref\|NP_806803.1\| bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltrans... gi\|16761974 - gi\|16761974\|ref\|NP_457591.1\| bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltrans... gi\|238910002 - gi\|238910002\|ref\|ZP_04653839.1\| bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltr... gi\|204322708, gi... - gi\|204928386\|ref\|ZP_03219586.1\| bifunctional protein HldE [Salmonella enterica subsp. enterica serov... gi\|213029251 - gi\|213029251\|ref\|ZP_03343698.1\| bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltr... gi\|213161055 - gi\|213161055\|ref\|ZP_03346765.1\| bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltr... gi\|213425620 - gi\|213425620\|ref\|ZP_03358370.1\| bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltr... HLDE_SALCH - Bifunctional protein hldE OS=Salmonella choleraesuis GN=hldE PE=3 SV=1 HLDE_SALSV - Bifunctional protein HldE OS=Salmonella schwarzengrund (strain CVM19633) GN=hldE PE=3 SV=1 HLDE_SALA4 - Bifunctional protein HldE OS=Salmonella agona (strain SL483) GN=hldE PE=3 SV=1 gi\|197240350, gi... - gi\|197262095\|ref\|ZP_03162169.1\| bifunctional protein HldE [Salmonella enterica subsp. enterica serov... gi\|200388570, gi... - gi\|200388570\|ref\|ZP_03215182.1\| bifunctional protein HldE [Salmonella enterica subsp. enterica serov... gi\|205343544, gi... - gi\|205343544\|gb\|EDZ30308.1\| bifunctional protein HldE [Salmonella enterica subsp. enterica serovar W... HLDE_SALNS - Bifunctional protein HldE OS=Salmonella newport (strain SL254) GN=hldE PE=3 SV=1 HLDE_SALHS - Bifunctional protein HldE OS=Salmonella heidelberg (strain SL476) GN=hldE PE=3 SV=1 gi\|194469139, gi... - gi\|194469139\|ref\|ZP_03075123.1\| bifunctional protein HldE [Salmonella enterica subsp. enterica serov... gi\|168238161, gi... - gi\|197288985\|gb\|EDY28356.1\| bifunctional protein HldE [Salmonella enterica subsp. enterica serovar S... gi\|205337923, gi... - gi\|205337923\|gb\|EDZ24687.1\| bifunctional protein HldE [Salmonella enterica subsp. enterica serovar H... gi\|205348445, gi... - gi\|205348445\|gb\|EDZ35076.1\| bifunctional protein HldE [Salmonella enterica subsp. enterica serovar H... gi\|168463589, gi... - gi\|195633633\|gb\|EDX52047.1\| bifunctional protein HldE [Salmonella enterica subsp. enterica serovar N... HLDE_SALTY - Bifunctional protein hldE OS=Salmonella typhimurium GN=hldE PE=3 SV=1 HLDE_SALPB - Bifunctional protein HldE OS=Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) GN=hldE PE=3 SV=1 HLDE_SALPC - Bifunctional protein HldE OS=Salmonella paratyphi C (strain RKS4594) GN=hldE PE=3 SV=1 lcl\|NC_016856.1_... - [gene=rfaE] [protein=bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase] ... HLDE_SALTI - Bifunctional protein hldE OS=Salmonella typhi GN=hldE PE=3 SV=1 gi\|213645908 - gi\|213645908\|ref\|ZP_03375961.1\| bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltr... gi\|213865027 - gi\|213865027\|ref\|ZP_03387146.1\| bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltr... gi\|213979927 - gi\|213979927\|ref\|ZP_03407186.1\| bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltr... gi\|214001827 - gi\|214001827\|ref\|ZP_03412562.1\| bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltr... HLDE_SALCH - Bifunctional protein hldE OS=Salmonella choleraesuis GN=hldE PE=3 SV=1 HLDE_SALCH - Bifunctional protein HldE OS=Salmonella choleraesuis (strain SC-B67) GN=hldE PE=3 SV=1 HLDE_SALTY - Bifunctional protein hldE OS=Salmonella typhimurium GN=hldE PE=3 SV=1	1.0E-52	[21..264]	[217..468]
gi\|13383336 - gi\|13383336\|gb\|AAK20933.1\|AF155126_1 ADP-heptose synthase [Salmonella typhimurium] gi\|13383336\|gb\|A... - ADP-heptose synthase [Salmonella typhimurium]	1.0E-52	[21..264]	[217..468]
gi\|5734094 - gi\|5734094\|gb\|AAD49846.1\|AF163661_1 RfaE [Salmonella enterica]	1.0E-52	[21..264]	[217..468]
HLDE_PASMU - Bifunctional protein hldE OS=Pasteurella multocida GN=hldE PE=3 SV=1 HLDE_PASMU - Bifunctional protein HldE OS=Pasteurella multocida (strain Pm70) GN=hldE PE=3 SV=1	3.0E-52	[32..264]	[228..468]
HLDE_ECO24 - Bifunctional protein HldE OS=Escherichia coli O139:H28 (strain E24377A / ETEC) GN=hldE PE=3 SV=1 gi\|194426262, gi... - gi\|75212315\|ref\|ZP_00712339.1\| COG2870: ADP-heptose synthase, bifunctional sugar kinase/adenylyltran... gi\|190901150, gi... - gi\|75227962\|ref\|ZP_00714657.1\| COG2870: ADP-heptose synthase, bifunctional sugar kinase/adenylyltran... gi\|192959254, gi... - gi\|75239377\|ref\|ZP_00723348.1\| COG2870: ADP-heptose synthase, bifunctional sugar kinase/adenylyltran... gi\|194436680, gi... - gi\|83587510\|ref\|ZP_00926137.1\| COG2870: ADP-heptose synthase, bifunctional sugar kinase/adenylyltran... HLDE_ECOL5 - Bifunctional protein HldE OS=Escherichia coli O6:K15:H31 (strain 536 / UPEC) GN=hldE PE=3 SV=1 HLDE_ECOSE - Bifunctional protein HldE OS=Escherichia coli (strain SE11) GN=hldE PE=3 SV=1 HLDE_ECOSM - Bifunctional protein HldE OS=Escherichia coli (strain SMS-3-5 / SECEC) GN=hldE PE=3 SV=1 HLDE_ECO8A - Bifunctional protein HldE OS=Escherichia coli O8 (strain IAI1) GN=hldE PE=3 SV=1 HLDE_ECO27 - Bifunctional protein HldE OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=hldE PE=3 SV=1 HLDE_ECO7I - Bifunctional protein HldE OS=Escherichia coli O7:K1 (strain IAI39 / ExPEC) GN=hldE PE=3 SV=1 HLDE_ECO55 - Bifunctional protein HldE OS=Escherichia coli (strain 55989 / EAEC) GN=hldE PE=3 SV=1 HLDE_ECOLI - Bifunctional protein hldE [Includes: D-beta-D-heptose 7-phosphate kinase (EC 2.7.1.-) (D-beta-D-hept... gi\|124526037, gi... - gi\|124526037\|ref\|ZP_01698042.1\| rfaE bifunctional protein [Escherichia coli B], gi\|124502141\|gb\|EAY4... sp\|B7UIW0\|HLDE_ECO27 - Bifunctional protein hldE OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=hldE PE=3 SV=1 HLDE_ECOBW - Bifunctional protein HldE OS=Escherichia coli (strain K12 / MC4100 / BW2952) GN=hldE PE=3 SV=1 gi\|251786329, gi... - gi\|251786329\|ref\|YP_003000633.1\| hypothetical protein B21_02872 [Escherichia coli BL21], gi\|24237860... gi\|253979056, gi... - gi\|254289749\|ref\|YP_003055497.1\| fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransfer... gi\|254038219, gi... - gi\|254038219\|ref\|ZP_04872277.1\| hldE [Escherichia sp. 1_1_43], gi\|226839843\|gb\|EEH71864.1\| hldE [Esc... gi\|254162999, gi... - gi\|254162999\|ref\|YP_003046107.1\| fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransfer... HLDE_ECODH - Bifunctional protein HldE OS=Escherichia coli (strain K12 / DH10B) GN=hldE PE=3 SV=1 HLDE_ECOLC - Bifunctional protein HldE OS=Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks) GN=hldE PE=3 SV... gi\|192932382, gi... - gi\|75259985\|ref\|ZP_00731263.1\| COG2870: ADP-heptose synthase, bifunctional sugar kinase/adenylyltran... EG13416 - heptose 7-phosphate kinase and heptose 1-phosphate adenyltransferase / Heptose 7-P kinase /heptose 1-... gi\|188491309, gi... - gi\|75511264\|ref\|ZP_00733962.1\| COG2870: ADP-heptose synthase, bifunctional sugar kinase/adenylyltran... gi\|89109822, gi\|... - gi\|89109822\|ref\|AP_003602.1\| fused heptose 7-phosphate kinase and heptose 1-phosphate adenyltransfer... EG13416 - heptose 7-phosphate kinase and heptose 1-phosphate adenyltransferase / Heptose 7-P kinase /heptose 1-...	7.0E-52	[21..264]	[217..468]
gi\|188017774, gi... - gi\|188017774\|gb\|EDU55896.1\| bifunctional protein HldE [Escherichia coli O157:H7 str. EC4113], gi\|168... gi\|168754020, gi... - gi\|189358657\|gb\|EDU77076.1\| bifunctional protein HldE [Escherichia coli O157:H7 str. EC4401], gi\|168... gi\|13363408, gi\|... - gi\|15833189\|ref\|NP_311962.1\| bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltrans... gi\|15803594, gi\|... - gi\|15803594\|ref\|NP_289627.1\| bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltrans... gi\|209759382, gi... - pir\|\|F85965 probable kinase Z4405 [imported] - Escherichia coli (strain O157:H7, substrain EDL933),... gi\|208734396, gi... - gi\|208813119\|ref\|ZP_03254448.1\| bifunctional protein HldE [Escherichia coli O157:H7 str. EC4045], gi... gi\|208739909, gi... - gi\|208819786\|ref\|ZP_03260106.1\| bifunctional protein HldE [Escherichia coli O157:H7 str. EC4042], gi... HLDE_ECO5E - Bifunctional protein HldE OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) GN=hldE PE=3 SV=1 gi\|217319269, gi... - gi\|217326902\|ref\|ZP_03442985.1\| bifunctional protein HldE [Escherichia coli O157:H7 str. TW14588], g... gi\|168785924, gi... - gi\|189374230\|gb\|EDU92646.1\| bifunctional protein HldE [Escherichia coli O157:H7 str. EC869], gi\|1687... gi\|189379666, gi... - gi\|189379666\|gb\|EDU98082.1\| bifunctional protein HldE [Escherichia coli O157:H7 str. EC508], gi\|1687... HLDE_ECO57 - Bifunctional protein HldE OS=Escherichia coli O157:H7 GN=hldE PE=3 SV=1 gi\|195937196 - gi\|195937196\|ref\|ZP_03082578.1\| bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltr... gi\|208726297, gi... - gi\|208806496\|ref\|ZP_03248833.1\| bifunctional protein HldE [Escherichia coli O157:H7 str. EC4206], gi... gi\|254795003, gi... - gi\|254795003\|ref\|YP_003079840.1\| bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenylt... gi\|168760211, gi... - gi\|189369293\|gb\|EDU87709.1\| bifunctional protein HldE [Escherichia coli O157:H7 str. EC4501], gi\|168... gi\|168767073, gi... - gi\|189363861\|gb\|EDU82280.1\| bifunctional protein HldE [Escherichia coli O157:H7 str. EC4486], gi\|168... gi\|168773293, gi... - gi\|187770866\|gb\|EDU34710.1\| bifunctional protein HldE [Escherichia coli O157:H7 str. EC4196], gi\|168... gi\|168781926, gi... - gi\|189000647\|gb\|EDU69633.1\| bifunctional protein HldE [Escherichia coli O157:H7 str. EC4076], gi\|168...	3.0E-51	[21..264]	[217..468]
gi\|218927847, gi... - gi\|218927847\|ref\|YP_002345722.1\| bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenylt... gi\|229842906, gi... - gi\|229842906\|ref\|ZP_04463058.1\| ADP-heptose synthase /D-glycero-beta-D-manno-heptose 7-phosphate kin... gi\|229696912, gi... - gi\|229840546\|ref\|ZP_04460705.1\| ADP-heptose synthase /D-glycero-beta-D-manno-heptose 7-phosphate kin... HLDE_YERPP - Bifunctional protein HldE OS=Yersinia pestis (strain Pestoides F) GN=hldE PE=3 SV=1 gi\|229705457, gi... - gi\|229837334\|ref\|ZP_04457497.1\| ADP-heptose synthase /D-glycero-beta-D-manno-heptose 7-phosphate kin... gi\|150260314, gi... - gi\|150260314\|ref\|ZP_01917042.1\| fused heptose 7-phosphate kinase and heptose 1-phosphate adenyltrans... HLDE_YERPG - Bifunctional protein HldE OS=Yersinia pestis bv. Antiqua (strain Angola) GN=hldE PE=3 SV=1 gi\|167398774, gi... - gi\|167398774\|ref\|ZP_02304298.1\| bifunctional protein HldE [Yersinia pestis biovar Antiqua str. UG05-... gi\|166963159, gi... - gi\|167419165\|ref\|ZP_02310918.1\| bifunctional protein HldE [Yersinia pestis biovar Orientalis str. MG... gi\|167425081, gi... - gi\|167425081\|ref\|ZP_02316834.1\| bifunctional protein HldE [Yersinia pestis biovar Mediaevalis str. K... HLDE_YERPA - Bifunctional protein HldE OS=Yersinia pestis bv. Antiqua (strain Antiqua) GN=hldE PE=3 SV=1 HLDE_YERPN - Bifunctional protein HldE OS=Yersinia pestis bv. Antiqua (strain Nepal516) GN=hldE PE=3 SV=1 HLDE_YERPE - Bifunctional protein HldE OS=Yersinia pestis GN=hldE PE=3 SV=1 gi\|165923340, gi... - gi\|165925140\|ref\|ZP_02220972.1\| bifunctional protein HldE [Yersinia pestis biovar Orientalis str. F1... gi\|165992105, gi... - gi\|166008766\|ref\|ZP_02229664.1\| bifunctional protein HldE [Yersinia pestis biovar Antiqua str. E1979... gi\|89102179, gi\|... - gi\|89102179\|ref\|ZP_01174833.1\| COG2870: ADP-heptose synthase, bifunctional sugar kinase/adenylyltran... gi\|166212244, gi... - gi\|166212244\|ref\|ZP_02238279.1\| bifunctional protein HldE [Yersinia pestis biovar Antiqua str. B4200...	9.0E-50	[21..264]	[217..468]

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Predicted Domain #1

Region A:
Residues: [1-118]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVEENSRVLI VLPYTPPSAT LQRIIGQTIP FLRECQSQLD IVIVPEFKTS FQLDSALGKM  60
   61 YSITRDVLLG YGMINSGINI IFNNIHFVES NLQWKVVLLP QESTFETWKL ELGQGQYH

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.889	0.069	pantetheine-phosphate adenylyltransferase activity	c.51.1	Anticodon-binding domain of Class II aaRS

Predicted Domain #2

Region A:
Residues: [119-305]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SIEHYALHDN IMEEIEGPKD ANKFHVTALG GTFDHIHDGH KILLSVSTFI TSQRLICGIT  60
   61 CDELLQNKKY KELIEPYDTR CRHVHQFIKL LKPDLSVELV PLRDVCGPTG KVPEIECLVV 120
  121 SRETVSGAET VNKTRIEKGM SPLAVHVVNV LGGREEDGWS EKLSSTEIRR LLKSSASPTC 180
  181 TPQNPCV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	23.045757
Match:	1cozA_
Description:	CTP:glycerol-3-phosphate cytidylyltransferase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
pantetheine-phosphate adenylyltransferase activity	2.8881527826831	bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds	2.80953822781392	bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds	2.80953822781392	bayes_pls_golite062009
aminoacyl-tRNA ligase activity	2.79852902055493	bayes_pls_golite062009
catalytic activity	2.37674226834122	bayes_pls_golite062009
ligase activity	2.038397138176	bayes_pls_golite062009
adenylyltransferase activity	1.08055019963499	bayes_pls_golite062009
pantoate-beta-alanine ligase activity	1.07698847477799	bayes_pls_golite062009
binding	0.965037527908742	bayes_pls_golite062009
nicotinate-nucleotide adenylyltransferase activity	0.692499879958128	bayes_pls_golite062009
nicotinamide-nucleotide adenylyltransferase activity	0.567882194154248	bayes_pls_golite062009
nucleotidyltransferase activity	0.427749234863188	bayes_pls_golite062009
nucleic acid binding	0.311743335409574	bayes_pls_golite062009
glutamate-tRNA ligase activity	0.142322351925094	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.097721445469396	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: