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View Structure Prediction Details

Protein: DS1P1_YEAST
Organism: Saccharomyces cerevisiae S288c
Length: 409 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DS1P1_YEAST.

Description E-value Query
Range
Subject
Range
DS1P1_YEAST - Dihydrosphingosine 1-phosphate phosphatase LCB3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S2...
LCB3 - Long-chain base-1-phosphate phosphatase with specificity for dihydrosphingosine-1-phosphate, regulat...
gi|207344105 - gi|207344105|gb|EDZ71354.1| YJL134Wp-like protein [Saccharomyces cerevisiae AWRI1631]
gi|190409371 - gi|190409371|gb|EDV12636.1| dihydrosphingosine-1-phosphate phophatase [Saccharomyces cerevisiae RM11...
0.0 [1..409] [1..409]
SPAC823.11 - sphingosine-1-phosphate phosphatase
DS1PP_SCHPO - Dihydrosphingosine 1-phosphate phosphatase C823.11 OS=Schizosaccharomyces pombe (strain 972 / ATCC 2...
6.0E-65 [47..403] [34..406]
SGPP1 - sphingosine-1-phosphate phosphatase 1
1.0E-62 [74..409] [124..441]
LPPD_ARATH - Lipid phosphate phosphatase delta OS=Arabidopsis thaliana GN=LPPD PE=2 SV=1
2.0E-61 [45..408] [31..416]
SGPP1_MOUSE - Sphingosine-1-phosphate phosphatase 1 OS=Mus musculus GN=Sgpp1 PE=1 SV=1
4.0E-57 [72..409] [111..430]
gi|85075896 - gi|85075896|ref|XP_955841.1| hypothetical protein [Neurospora crassa OR74A]
gi|18376322, gi|... - gi|32404298|ref|XP_322762.1| hypothetical protein [Neurospora crassa], gi|28916862|gb|EAA26605.1| hy...
7.0E-56 [69..356] [2..295]
gi|409159 - gi|409159|gb|AAA73940.1| phosphatase
3.0E-44 [56..409] [4..339]

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Predicted Domain #1
Region A:
Residues: [1-112]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVDGLNTSNI RKRARTLSNP NDFQEPNYLL DPGNHPSDHF RTRMSKFRFN IREKLLVFTN  60
   61 NQSFTLSRWQ KKYRSAFNDL YFTYTSLMGS HTFYVLCLPM PVWFGYFETT KD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.572 a.1.1 Globin-like
View Download 0.416 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.372 a.118.1 ARM repeat
View Download 0.382 a.118.9 ENTH/VHS domain
View Download 0.563 a.4.3 ARID-like
View Download 0.322 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.292 d.14.1 Ribosomal protein S5 domain 2-like
View Download 0.289 a.4.5 "Winged helix" DNA-binding domain
View Download 0.278 i.11.1 Computational models partly based on NMR data
View Download 0.268 d.13.1 HIT-like
View Download 0.264 a.24.16 Nucleotidyltransferase substrate binding subunit/domain
View Download 0.255 a.2.7 tRNA-binding arm
View Download 0.246 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.243 a.7.6 Ribosomal protein S20
View Download 0.239 a.142.1 PTS-regulatory domain, PRD
View Download 0.233 a.29.4 RecG, N-terminal domain
View Download 0.233 a.1.1 Globin-like
View Download 0.225 a.1.1 Globin-like
View Download 0.209 a.47.2 t-snare proteins
View Download 0.208 a.24.7 FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
View Download 0.200 a.7.1 Spectrin repeat

Predicted functions:

Term Confidence Notes
catalytic activity 0.767627914425245 bayes_pls_golite062009
phosphatase activity 0.722810330266611 bayes_pls_golite062009
phosphoric ester hydrolase activity 0.534563060036778 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [113-268]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVYILGYSIY LSGFFKDYWC LPRPRAPPLH RITLSEYTTK EYGAPSSHTA NATGVSLLFL  60
   61 YNIWRMQESS VMVQLLLSCV VLFYYMTLVF GRIYCGMHGI LDLVSGGLIG IVCFIVRMYF 120
  121 KYRFPGLRIE EHWWFPLFSV GWGLLLLFKH VKPVDE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 20.0
Match: 1d2tA_
Description: Bacterial acid phosphatase
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [269-409]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CPCFQDSVAF MGVVSGIECC DWLGKVFGVT LVYNLEPNCG WRLTLARLLV GLPCVVIWKY  60
   61 VISKPMIYTL LIKVFHLKDD RNVAARKRLE ATHKEGASKY ECPLYIGEPK IDILGRFIIY 120
  121 AGVPFTVVMC SPVLFSLLNI A

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.617 a.1.1 Globin-like
View Download 0.646 f.14.1 Voltage-gated potassium channels
View Download 0.715 a.47.2 t-snare proteins
View Download 0.766 a.24.9 alpha-catenin/vinculin
View Download 0.607 f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.550 f.18.1 F1F0 ATP synthase subunit A
View Download 0.507 a.24.3 Cytochromes
View Download 0.501 a.29.3 Acyl-CoA dehydrogenase C-terminal domain-like
View Download 0.494 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.493 a.118.12 Ran-GTPase activating protein 1 (RanGAP1), C-terminal domain
View Download 0.483 a.25.1 Ferritin-like
View Download 0.467 a.2.7 tRNA-binding arm
View Download 0.457 i.11.1 Computational models partly based on NMR data
View Download 0.447 f.25.1 Cytochrome c oxidase subunit III-like
View Download 0.437 a.7.1 Spectrin repeat
View Download 0.428 c.55.4 Translational machinery components
View Download 0.419 a.60.9 lambda integrase-like, N-terminal domain
View Download 0.419 a.25.2 Thermoplasma ferritin-like 4-helical bundle
View Download 0.414 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.408 a.133.1 Phospholipase A2, PLA2
View Download 0.392 a.19.1 Fertilization protein
View Download 0.390 a.73.1 Retrovirus capsid protein, N-terminal core domain
View Download 0.381 c.47.1 Thioredoxin-like
View Download 0.376 a.118.1 ARM repeat
View Download 0.369 a.24.9 alpha-catenin/vinculin
View Download 0.368 d.167.1 Peptide deformylase
View Download 0.363 a.24.16 Nucleotidyltransferase substrate binding subunit/domain
View Download 0.362 a.7.7 BAG domain
View Download 0.360 a.29.3 Acyl-CoA dehydrogenase C-terminal domain-like
View Download 0.339 a.25.1 Ferritin-like
View Download 0.326 a.126.1 Serum albumin-like
View Download 0.302 a.36.1 Signal peptide-binding domain
View Download 0.282 a.1.1 Globin-like
View Download 0.279 a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.277 d.162.1 LDH C-terminal domain-like
View Download 0.273 a.24.3 Cytochromes
View Download 0.271 a.66.1 Transducin (alpha subunit), insertion domain
View Download 0.270 a.7.4 Smac/diablo
View Download 0.266 a.7.8 GAT domain
View Download 0.247 a.2.7 tRNA-binding arm
View Download 0.245 a.90.1 Transcription factor STAT-4 N-domain
View Download 0.240 d.173.1 Methionine synthase activation domain-like
View Download 0.238 a.74.1 Cyclin-like
View Download 0.220 a.61.1 Retroviral matrix proteins
View Download 0.209 a.7.3 Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain
View Download 0.207 f.21.1 Transmembrane di-heme cytochromes
View Download 0.203 a.71.1 Endoplasmic reticulum protein ERP29, C-domain
View Download 0.203 a.11.2 Second domain of FERM
View Download 0.202 a.22.1 Histone-fold
View Download 0.202 a.69.3 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain


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