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View Structure Prediction Details

Protein: EMP24_YEAST
Organism: Saccharomyces cerevisiae S288c
Length: 203 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for EMP24_YEAST.

Description E-value Query
Range		 Subject
Range
TMEDA_MOUSE - Transmembrane emp24 domain-containing protein 10 OS=Mus musculus GN=Tmed10 PE=1 SV=1
gi|55715792 - gb|AAH86255.1| Unknown (protein for MGC:98776) [Xenopus laevis]
 1.0E-53 [3..203] [13..218]
TMEDA_MESAU - Transmembrane protein Tmp21 OS=Mesocricetus auratus GN=TMED10 PE=1 SV=1
 2.0E-52 [7..203] [18..218]
TMEDA_RABIT - Transmembrane emp24 domain-containing protein 10 OS=Oryctolagus cuniculus GN=TMED10 PE=1 SV=1
 4.0E-52 [7..203] [18..218]
gi|14042242 - gi|14042242|dbj|BAB55166.1| unnamed protein product [Homo sapiens]
 4.0E-52 [7..201] [23..216]
TMEDA_RAT - Transmembrane emp24 domain-containing protein 10 OS=Rattus norvegicus GN=Tmed10 PE=1 SV=2
 2.0E-51 [7..203] [18..218]
gi|190407139 - gi|190407139|gb|EDV10406.1| type I transmembrane protein [Saccharomyces cerevisiae RM11-1a]
gi|207345513 - gi|207345513|gb|EDZ72312.1| YGL200Cp-like protein [Saccharomyces cerevisiae AWRI1631]
EMP24_YEAST - Endosomal protein P24B OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=EMP24 PE=1 SV=1
EMP24 - Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function i...
gi|151943617 - gi|151943617|gb|EDN61927.1| conserved protein [Saccharomyces cerevisiae YJM789]
 2.0E-50 [1..203] [1..203]

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Predicted Domain #1
Region A:
Residues: [1-203] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASFATKFVI ACFLFFSASA HNVLLPAYGR RCFFEDLSKG DELSISFQFG DRNPQSSSQL  60
   61 TGDFIIYGPE RHEVLKTVRD TSHGEITLSA PYKGHFQYCF LNENTGIETK DVTFNIHGVV 120
  121 YVDLDDPNTN TLDSAVRKLS KLTREVKDEQ SYIVIRERTH RNTAESTNDR VKWWSIFQLG 180
  181 VVIANSLFQI YYLRRFFEVT SLV

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 81.387216
Match: PF01105
Description: emp24/gp25L/p24 family/GOLD

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
voltage-gated cation channel activity 2.66540214971227 bayes_pls_golite062009
substrate-specific channel activity 2.66283817406605 bayes_pls_golite062009
passive transmembrane transporter activity 2.65916906094646 bayes_pls_golite062009
channel activity 2.65916906094646 bayes_pls_golite062009
cation channel activity 2.62747969257897 bayes_pls_golite062009
potassium channel activity 2.61371256192732 bayes_pls_golite062009
voltage-gated ion channel activity 2.60719363833593 bayes_pls_golite062009
ion channel activity 2.60082350471123 bayes_pls_golite062009
voltage-gated channel activity 2.58448165457823 bayes_pls_golite062009
voltage-gated potassium channel activity 2.57450407680312 bayes_pls_golite062009
gated channel activity 2.51455369837435 bayes_pls_golite062009
metal ion transmembrane transporter activity 2.48447488950861 bayes_pls_golite062009
ligand-gated ion channel activity 2.48200622858578 bayes_pls_golite062009
ligand-gated channel activity 2.48200622858578 bayes_pls_golite062009
transporter activity 2.35657262831396 bayes_pls_golite062009
clathrin binding 2.30826135071113 bayes_pls_golite062009
transmembrane transporter activity 2.25147059981728 bayes_pls_golite062009
substrate-specific transporter activity 2.22751878261824 bayes_pls_golite062009
binding 2.16129867759095 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 2.14804562881998 bayes_pls_golite062009
ion transmembrane transporter activity 2.08500207462933 bayes_pls_golite062009
cation transmembrane transporter activity 2.02275538762334 bayes_pls_golite062009
inward rectifier potassium channel activity 1.9397436784802 bayes_pls_golite062009
molecular transducer activity 1.58932339453245 bayes_pls_golite062009
signal transducer activity 1.58932339453245 bayes_pls_golite062009
protein binding 1.40069187357924 bayes_pls_golite062009
cytoskeletal protein binding 0.921436605338431 bayes_pls_golite062009
actin binding 0.852579554611056 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle