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View Structure Prediction Details

Protein: FRE3_YEAST
Organism: Saccharomyces cerevisiae S288c
Length: 711 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FRE3_YEAST.

Description E-value Query
Range
Subject
Range
FRE3_YEAST - Ferric reductase transmembrane component 3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) ...
gi|151945455 - gi|151945455|gb|EDN63698.1| ferric reductase transmembrane component [Saccharomyces cerevisiae YJM78...
FRE3 - Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; expression induced...
gi|190407670 - gi|190407670|gb|EDV10937.1| ferric reductase transmembrane component [Saccharomyces cerevisiae RM11-...
0.0 [1..711] [1..711]
gi|3242456 - gi|3242456|dbj|BAA28953.1| Atrboh F [Arabidopsis thaliana]
0.0 [23..708] [186..944]
gi|28268678 - gi|28268678|dbj|BAC56864.1| respiratory burst oxidase homolog [Nicotiana benthamiana]
0.0 [30..708] [204..962]
RBOHB_SOLTU - Respiratory burst oxidase homolog protein B OS=Solanum tuberosum GN=RBOHB PE=1 SV=1
0.0 [25..708] [122..867]
gi|17384016 - gi|17384016|emb|CAC87256.1| NADPH oxidase [Nicotiana tabacum]
0.0 [30..708] [204..962]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [23..708] [186..977]

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Predicted Domain #1
Region A:
Residues: [1-188]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYWVLLCGSI LLCCLSGASA SPAKTKMYGK LPLVLTDACM GVLGEVTWEY SSDDLYSSPA  60
   61 CTYEPALQSM LYCIYESLNE KGYSNRTFEK TFAAIKEDCA YYTDNLQNMT NADFYNMLNN 120
  121 GTTYIIQYSE GSANLTYPIE MDAQVRENYY YSYHGFYANY DIGHTYGGII CAYFVGVMIL 180
  181 ASILHYLS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.30103
Match: 1g8iA_
Description: Frequenin (neuronal calcium sensor 1)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cation binding 2.62077305565026 bayes_pls_golite062009
metal ion binding 2.62077305565026 bayes_pls_golite062009
metal ion transmembrane transporter activity 2.61874575467092 bayes_pls_golite062009
ion binding 2.61312132078717 bayes_pls_golite062009
ion transmembrane transporter activity 2.57032504567157 bayes_pls_golite062009
cation transmembrane transporter activity 2.55650624542181 bayes_pls_golite062009
binding 2.54774920478325 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 2.37465721152046 bayes_pls_golite062009
cation channel activity 1.49312394054212 bayes_pls_golite062009
calcium ion binding 1.40919295397643 bayes_pls_golite062009
transporter activity 1.15928534291452 bayes_pls_golite062009
protein binding 1.06263369232144 bayes_pls_golite062009
channel activity 1.05847414989139 bayes_pls_golite062009
passive transmembrane transporter activity 1.05847414989139 bayes_pls_golite062009
ion channel activity 1.0369591011376 bayes_pls_golite062009
substrate-specific channel activity 1.03529144716694 bayes_pls_golite062009
voltage-gated cation channel activity 0.986621437232479 bayes_pls_golite062009
transmembrane transporter activity 0.945691505472547 bayes_pls_golite062009
voltage-gated ion channel activity 0.910148857310729 bayes_pls_golite062009
potassium channel activity 0.906643355854798 bayes_pls_golite062009
voltage-gated channel activity 0.896351900356978 bayes_pls_golite062009
gated channel activity 0.855502499003241 bayes_pls_golite062009
voltage-gated potassium channel activity 0.810245330492755 bayes_pls_golite062009
substrate-specific transporter activity 0.693724160233023 bayes_pls_golite062009
transcription regulator activity 0.529057692398468 bayes_pls_golite062009
molecular transducer activity 0.503769734882556 bayes_pls_golite062009
signal transducer activity 0.503769734882556 bayes_pls_golite062009
hydrolase activity 0.378268353045111 bayes_pls_golite062009
nucleic acid binding 0.345084390599452 bayes_pls_golite062009
0.34446792626966 bayes_pls_golite062009
channel regulator activity 0.32809521759917 bayes_pls_golite062009
active transmembrane transporter activity 0.246383459363256 bayes_pls_golite062009
DNA binding 0.14285249145193 bayes_pls_golite062009
cytoskeletal protein binding 0.0776924650284998 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [189-356]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YTPFKTALFK QRLVRYVRRY LTIPTIWGKH ASSFSYLKIF TGFLPTRSEG VIILGYLVLH  60
   61 TVFLAYGYQY DPYNLIFDSR REQIARYVAD RSGVLAFAHF PLIALFAGRN NFLEFISGVK 120
  121 YTSFIMFHKW LGRMMFLDAV IHGAAYTSYS VFYKDWAASK EETYWQFG

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [357-529]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VAALCIVGVM VFFSLAMFRK FFYEAFLFLH IVLGALFFYT CWEHVVELSG IEWIYAAIAI  60
   61 WTIDRLIRIV RVSYFGFPKA SLQLVGDDII RVTVKRPVRL WKAKPGQYVF VSFLHHLYFW 120
  121 QSHPFTVLDS IIKDGELTII LKEKKGVTKL VKKYVCCNGG KASMRLAIEG PYG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 51.30103
Match: 1ndh__
Description: cytochrome b5 reductase
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [530-711]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSSPVNNYDN VLLLTGGTGL PGPIAHAIKL GKTSAATGKQ FIKLVIAVRG FNVLEAYKPE  60
   61 LMCLEDLNVQ LHIYNTMEVP ALTPNDSLEI SQQDEKADGK GVVMATTLEQ SPNPVEFDGT 120
  121 VFHHGRPNVE KLLHEVGDLN GSLAVVCCGP PVFVDEVRDQ TANLVLEKPA KAIEYFEEYQ 180
  181 SW

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 51.30103
Match: 1ndh__
Description: cytochrome b5 reductase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
catalytic activity 1.45374095556065 bayes_pls_golite062009
transferase activity 1.15480450573972 bayes_pls_golite062009
binding 1.13408475648113 bayes_pls_golite062009
oxidoreductase activity 0.27336340260908 bayes_pls_golite062009
protein binding 0.144900113694048 bayes_pls_golite062009
cofactor binding 0.0731141170494622 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle