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View Structure Prediction Details

Protein: WHI4_YEAST
Organism: Saccharomyces cerevisiae S288c
Length: 649 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for WHI4_YEAST.

Description E-value Query
Range
Subject
Range
WHI4_YEAST - Protein WHI4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=WHI4 PE=1 SV=1
gi|207347167 - gi|207347167|gb|EDZ73442.1| YDL224Cp-like protein [Saccharomyces cerevisiae AWRI1631]
WHI4 - Putative RNA binding protein and partially redundant Whi3p homolog that regulates the cell size requ...
0.0 [1..649] [1..649]
PCLO_CHICK - Protein piccolo (Fragment) OS=Gallus gallus GN=PCLO PE=2 SV=1
9.0E-77 [172..534] [17..372]
PCLO_RAT - Protein piccolo OS=Rattus norvegicus GN=Pclo PE=1 SV=1
2.0E-74 [173..526] [104..480]
PCLO_MOUSE - (Q9QYX7) Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN ...
3.0E-69 [174..533] [106..447]
gi|6433936 - gi|6433936|emb|CAB60727.1| aczonin [Homo sapiens]
2.0E-49 [173..527] [72..466]

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Predicted Domain #1
Region A:
Residues: [1-326]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLVHNQTNL NESKFLIERA FSSSSETVPL SKEATYPMPT AYSFSAVRSN SETNIKRENP  60
   61 QGFAKEPIMT SMLHNLTMST GKGNGNDVNS LAPHDVDVGP YCLLLRNLPK DITLRECYCI 120
  121 FSLATGVSSI ELKRDDREPF NDNEKVVVVK FGSLSLVTHY ANILNSKSEI FGPSFPFRSH 180
  181 IDVVNEQTQL PVSFQEHVSS GTTNSSPKNY QLSSSAQNEI QNQSFNTISY GKTSSSPLGP 240
  241 SAAKPRPSLL SERSLRFSFN DPFGLETISQ RKESVPFLRN SISQHDLSNV TTTPVPAGMP 300
  301 PQKDAGKSLL LLEKDEINES IWNGDE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [327-447]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LVNDVGNSSF GASLQEPPMS STPVMEWNAS STANIPLFQL SSQENHQSNL LPPSHHSISQ  60
   61 DVPHIQSQPN LNNSGVIHSA TSLPHYHLLN QINASTKTQS IQQSVSNVPS NLDLNLQTEN 120
  121 G

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted functions:

Term Confidence Notes
binding 2.80563734517858 bayes_pls_golite062009
nucleic acid binding 2.10800250002791 bayes_pls_golite062009
RNA binding 1.27892507616795 bayes_pls_golite062009
protein binding 1.02232785292059 bayes_pls_golite062009
mRNA binding 0.358102192108578 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [448-511]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HPQSSAPNGS SIFNNQKVNQ GFLVSEQDTS TISRQKECSS TASASAFSKN NETNVAGSTT  60
   61 ISQA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.501 d.58.17 Metal-binding domain
View Download 0.427 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.291 g.59.1 Zinc-binding domain of translation initiation factor 2 beta
View Download 0.253 a.60.3 C-terminal domain of RNA polymerase alpha subunit
View Download 0.246 d.58.1 4Fe-4S ferredoxins
View Download 0.215 d.129.1 TATA-box binding protein-like

Predicted functions:

Term Confidence Notes
binding 2.80563734517858 bayes_pls_golite062009
nucleic acid binding 2.10800250002791 bayes_pls_golite062009
RNA binding 1.27892507616795 bayes_pls_golite062009
protein binding 1.02232785292059 bayes_pls_golite062009
mRNA binding 0.358102192108578 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [512-649]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DLSLLAKVPP PANPADQNPP CNTLYVGNLP PDATEQELRQ LFSNQQGFRR LSFRNKMNSH  60
   61 GHGNGHGHGP ICFVEFEDVS FATRALAELY GSQLPHPRPS LNNKGGIRLS FSKNPLGVRG 120
  121 SNSRSKSGYS FNGSYGKS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 37.232149
Match: 2u1a__
Description: Splicesomal U1A protein
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle