YRC Public Data Repository - Protein Structure Prediction

Protein:	TYSY_SHEON
Organism:	Shewanella oneidensis MR-1
Length:	264 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TYSY_SHEON.

Description	E-value	Query Range	Subject Range
gi\|6460459, gi\|1... - gi\|6460459\|gb\|AAF12166.1\|AE002092_4 thymidylate synthase [Deinococcus radiodurans R1], gi\|15807610\|r... gi\|7473980 - pir\|\|E75250 thymidylate synthase - Deinococcus radiodurans (strain R1)	477.0	[0..2]	[264..125]
TYSY_CHRVO - Thymidylate synthase OS=Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 1... TYSY_CHRVO - Thymidylate synthase OS=Chromobacterium violaceum GN=thyA PE=3 SV=1	474.0	[0..1]	[264..1]
gi\|11256673 - pir\|\|G81050 thymidylate synthase NMB1709 [imported] - Neisseria meningitidis (strain MC58 serogroup ... TYSY_NEIMB - Thymidylate synthase OS=Neisseria meningitidis serogroup B (strain MC58) GN=thyA PE=3 SV=1 TYSY_NEIMB - Thymidylate synthase OS=Neisseria meningitidis serogroup B GN=thyA PE=3 SV=1	473.0	[0..1]	[264..1]
gi\|11256672 - pir\|\|A81825 thymidylate synthase (EC 2.1.1.45) NMA1963 [imported] - Neisseria meningitidis (strain Z... TYSY_NEIMA - Thymidylate synthase OS=Neisseria meningitidis serogroup A GN=thyA PE=3 SV=1 TYSY_NEIMA - Thymidylate synthase OS=Neisseria meningitidis serogroup A / serotype 4A (strain Z2491) GN=thyA PE=3...	473.0	[0..1]	[264..1]
gi\|240017051 - gi\|240017051\|ref\|ZP_04723591.1\| thymidylate synthase [Neisseria gonorrhoeae FA6140] gi\|240014606 - gi\|240014606\|ref\|ZP_04721519.1\| thymidylate synthase [Neisseria gonorrhoeae DGI18] gi\|239999430 - gi\|239999430\|ref\|ZP_04719354.1\| thymidylate synthase [Neisseria gonorrhoeae 35/02] gi\|240118411 - gi\|240118411\|ref\|ZP_04732473.1\| thymidylate synthase [Neisseria gonorrhoeae PID1] gi\|240116127 - gi\|240116127\|ref\|ZP_04730189.1\| thymidylate synthase [Neisseria gonorrhoeae PID18] gi\|240113520 - gi\|240113520\|ref\|ZP_04728010.1\| thymidylate synthase [Neisseria gonorrhoeae MS11] gi\|240081310 - gi\|240081310\|ref\|ZP_04725853.1\| thymidylate synthase [Neisseria gonorrhoeae FA19] TYSY_NEIG1 - Thymidylate synthase OS=Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090) GN=thyA PE=3 SV=1 gi\|240128633 - gi\|240128633\|ref\|ZP_04741294.1\| thymidylate synthase [Neisseria gonorrhoeae SK-93-1035] gi\|240126156 - gi\|240126156\|ref\|ZP_04739042.1\| thymidylate synthase [Neisseria gonorrhoeae SK-92-679] gi\|240123956 - gi\|240123956\|ref\|ZP_04736912.1\| thymidylate synthase [Neisseria gonorrhoeae PID332] gi\|240121128 - gi\|240121128\|ref\|ZP_04734090.1\| thymidylate synthase [Neisseria gonorrhoeae PID24-1] gi\|226513187, gi... - gi\|254494147\|ref\|ZP_05107318.1\| thymidylate synthase [Neisseria gonorrhoeae 1291], gi\|226513187\|gb\|E...	472.0	[0..1]	[264..1]
TYSY_METFK - Thymidylate synthase OS=Methylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875) GN=thyA1 PE=...	469.0	[0..1]	[264..1]
TYSY_PSEA7 - Thymidylate synthase OS=Pseudomonas aeruginosa (strain PA7) GN=thyA PE=3 SV=1	469.0	[0..1]	[264..1]
TYSY_PSEAE - Thymidylate synthase OS=Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)... TYSY_PSEAB - Thymidylate synthase OS=Pseudomonas aeruginosa (strain UCBPP-PA14) GN=thyA PE=3 SV=1 gi\|254237422, gi... - gi\|84318475\|ref\|ZP_00966898.1\| COG0207: Thymidylate synthase [Pseudomonas aeruginosa C3719], gi\|2542... gi\|126196819, gi... - gi\|84324426\|ref\|ZP_00972484.1\| COG0207: Thymidylate synthase [Pseudomonas aeruginosa 2192], gi\|25424... gi\|107099326 - gi\|107099326\|ref\|ZP_01363244.1\| hypothetical protein PaerPA_01000338 [Pseudomonas aeruginosa PACS2] TYSY_PSEAE - Thymidylate synthase OS=Pseudomonas aeruginosa GN=thyA PE=3 SV=1 TYSY_PSEA8 - Thymidylate synthase OS=Pseudomonas aeruginosa (strain LESB58) GN=thyA PE=3 SV=1	469.0	[0..1]	[264..1]
gi\|72118031, gi\|... - gi\|73540618\|ref\|YP_295138.1\| thymidylate synthase [Ralstonia eutropha JMP134], gi\|72118031\|gb\|AAZ602...	469.0	[0..1]	[264..18]
TYSY_BACHD - Thymidylate synthase OS=Bacillus halodurans GN=thyA PE=3 SV=1 TYSY_BACHD - Thymidylate synthase OS=Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 ...	468.0	[0..1]	[264..1]

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Predicted Domain #1

Region A:
Residues: [1-264]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQQYLDLMKH ILAEGVDKSD RTGTGTRSVF GYQMRFDLSK GFPLVTTKKC HMRSIIHELL  60
   61 WFLKGDTNIA YLRDNKVSIW DEWADENGDL GPVYGAQWRS WPTQSGEAID QISQVIAQIK 120
  121 SQPDSRRLIV SAWNVGELDK MALAPCHAFF QFYVADGKLS CQLYQRSCDV FLGLPFNIAS 180
  181 YALLTMMVAQ QCDLALGDFV WTGGDTHLYS NHMEQTALQL SREPRPLPTM TILRKPASIF 240
  241 DYQFDDFALS NYDPHPHIKA PVAV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	133.0
Match:	1f4bA
Description:	Thymidylate synthase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
thymidylate synthase activity	6.6988475347328	bayes_pls_golite062009
5,10-methylenetetrahydrofolate-dependent methyltransferase activity	6.29181090719132	bayes_pls_golite062009
binding	1.89072001556053	bayes_pls_golite062009
catalytic activity	1.73427871128495	bayes_pls_golite062009
transferase activity	1.72626940963556	bayes_pls_golite062009
methyltransferase activity	0.927096828883487	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	0.91282507161672	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: