YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|30262012, gi\|...
Organism:	Bacillus anthracis str. Ames
Length:	412 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|30262012, gi|....

Description	E-value	Query Range	Subject Range
gi\|49610951, gi\|... - gi\|50120425\|ref\|YP_049592.1\| non-ribosomal peptide synthetase [Pectobacterium atrosepticum SCRI1043]...	3.0E-93	[2..411]	[2688..3168]
gi\|75701558, gi\|... - gi\|75907833\|ref\|YP_322129.1\| amino acid adenylation [Anabaena variabilis ATCC 29413], gi\|75701558\|gb...	3.0E-93	[2..412]	[563..1045]
gi\|56419203, gi\|... - gi\|56419203\|ref\|YP_146521.1\| acyl-CoA synthetase [Geobacillus kaustophilus HTA426], gi\|56379045\|dbj\|...	1.0E-91	[3..412]	[21..512]
gi\|17131741, gi\|... - gi\|17230140\|ref\|NP_486688.1\| peptide synthetase [Nostoc sp. PCC 7120], gi\|17131741\|dbj\|BAB74347.1\| p... gi\|25294032 - pir\|\|AI2136 peptide synthetase [imported] - Nostoc sp. (strain PCC 7120)	3.0E-90	[2..412]	[479..971]
TYCC_BREPA - Tyrocidine synthase 3 OS=Brevibacillus parabrevis GN=tycC PE=1 SV=1 gi\|2623773, gi\|7... - gi\|7522159\|pir\|\|T31076 tyrocidine synthetase 3 - Brevibacillus brevis, gi\|2623773\|gb\|AAC45930.1\| tyr...	2.0E-89	[2..409]	[1519..1991]
gi\|89199773, gi\|... - gi\|89199773\|ref\|ZP_01178530.1\| Amino acid adenylation [Bacillus cereus subsp. cytotoxis NVH 391-98],...	7.0E-89	[2..411]	[1535..2029]
gi\|186682529, gi... - gi\|23129063\|ref\|ZP_00110897.1\| COG1020: Non-ribosomal peptide synthetase modules and related protein...	1.0E-88	[2..412]	[1588..2067]
gi\|89203970, gi\|... - gi\|89203970\|ref\|ZP_01182549.1\| Non-ribosomal peptide synthase:Amino acid adenylation [Bacillus weihe...	2.0E-88	[2..409]	[2614..3096]

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Predicted Domain #1

Region A:
Residues: [1-412]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLIVNREEYS KSDFDLRLQA YEEMEQFQEA AGNRFALCLK DPFDIITLVF FLKEKKSSVL  60
   61 LIHEDTPKET AIEMAKRANC IGILYGENSD FTKLEAVNYL AEEPSLLQYS SGTTGEPKLI 120
  121 RRAWTEVDTE IKVYNEALNC DIDEVPIVMA PVSHSYGLIC GTLSAITRGS KPIIITNKNP 180
  181 KFALNIVRNT EKHIVYAVPL MLHIMGSFPQ GTFQFHKIMT SGAPLPEALF YKLKETTTYM 240
  241 MQQYGCSEAG CISICHDMKS HLDLGNPLPH ASISIGSDEN APEEIIVKMN DKEIFTKDLG 300
  301 YKSERGLHFM GRMDDVINVS GLKVFPIEVE ETMLRLEGVQ EAIVYRGKHP VMGEIVKAKV 360
  361 ISHIDPVQIR EWCMQHLPSY KVPHEIESVT EIPKNKTGKV SRKLLEMGEV TT

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	78.522879
Match:	1amuA
Description:	Phenylalanine activating domain of gramicidin synthetase 1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ligase activity, forming carbon-sulfur bonds	2.82174699142286	bayes_pls_golite062009
catalytic activity	2.20589179498934	bayes_pls_golite062009
acid-thiol ligase activity	2.03342160490677	bayes_pls_golite062009
CoA-ligase activity	1.74361558346113	bayes_pls_golite062009
acetate-CoA ligase activity	1.55149187194463	bayes_pls_golite062009
o-succinylbenzoate-CoA ligase activity	0.97784533685802	bayes_pls_golite062009
ligase activity	0.945498760744099	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: