YRC Public Data Repository - Protein Structure Prediction

Protein:	ISPF_PECAS
Organism:	Pectobacterium atrosepticum SCRI1043
Length:	165 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ISPF_PECAS.

Description	E-value	Query Range	Subject Range
ISPF_HAEIE - 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase OS=Haemophilus influenzae (strain PittEE) GN=i... ISPF_HAEIN - 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase OS=Haemophilus influenzae GN=ispF PE=1 SV=1 ISPF_HAEIN - 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase OS=Haemophilus influenzae (strain ATCC 51907 /... gi\|229847228, gi... - gi\|229847228\|ref\|ZP_04467332.1\| 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [Haemophilus i...	266.0	[0..1]	[157..2]
gi\|145629642, gi... - gi\|145629642\|ref\|ZP_01785439.1\| 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [Haemophilus i... gi\|46133032 - gi\|46133032\|ref\|ZP_00156473.2\| COG0245: 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [Haemop...	266.0	[0..1]	[157..2]
ISPF_BACCN - 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase OS=Bacillus cytotoxicus (strain DSM 22905 / CI...	265.0	[0..2]	[157..3]
gi\|42628891 - gi\|42628891\|ref\|ZP_00154443.1\| COG0245: 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [Haemop...	265.0	[0..1]	[157..2]
ISPF_ACTP2 - 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase OS=Actinobacillus pleuropneumoniae serotype 5b... gi\|46143508 - gi\|46143508\|ref\|ZP_00204492.1\| COG0245: 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [Actino... ISPF_ACTPJ - 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase OS=Actinobacillus pleuropneumoniae serotype 3 ...	265.0	[0..1]	[157..2]
ISPF_BACC1 - 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase OS=Bacillus cereus (strain ATCC 10987 / NRS 24...	265.0	[0..2]	[157..3]
ISPF_HAEDU - 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase OS=Haemophilus ducreyi GN=ispF PE=3 SV=1 ISPF_HAEDU - 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase OS=Haemophilus ducreyi (strain 35000HP / ATCC ...	264.0	[0..1]	[158..2]
ISPF_BACCQ - 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase OS=Bacillus cereus (strain Q1) GN=ispF PE=3 SV... gi\|228834262, gi... - gi\|228925340\|ref\|ZP_04088436.1\| 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [Bacillus thur... gi\|228919037, gi... - gi\|228919037\|ref\|ZP_04082416.1\| 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [Bacillus thur... gi\|228846762, gi... - gi\|228912826\|ref\|ZP_04076473.1\| 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [Bacillus thur... gi\|228905884, gi... - gi\|228905884\|ref\|ZP_04069781.1\| 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [Bacillus thur... gi\|228898840, gi... - gi\|228898840\|ref\|ZP_04063122.1\| 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [Bacillus thur... ISPF_BACAC - 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase OS=Bacillus anthracis (strain CDC 684 / NRRL 3... ISPF_BACC3 - 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase OS=Bacillus cereus (strain 03BB102) GN=ispF PE... gi\|170707593, gi... - gi\|170707593\|ref\|ZP_02898046.1\| 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [Bacillus anthr... gi\|190559905, gi... - gi\|190568981\|ref\|ZP_03021882.1\| 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [Bacillus anthr... gi\|196036363, gi... - gi\|196036363\|ref\|ZP_03103760.1\| 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [Bacillus cereu... gi\|196027395, gi... - gi\|196041775\|ref\|ZP_03109065.1\| 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [Bacillus cereu... gi\|206743422, gi... - gi\|206978361\|ref\|ZP_03239234.1\| 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [Bacillus cereu... ISPF_BACC7 - 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase OS=Bacillus cereus (strain AH187) GN=ispF PE=3... ISPF_BACC2 - 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase OS=Bacillus cereus (strain G9842) GN=ispF PE=3... ISPF_BACC0 - 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase OS=Bacillus cereus (strain AH820) GN=ispF PE=3... ISPF_BACHK - 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase OS=Bacillus thuringiensis subsp. konkukian GN=... gi\|254758393 - gi\|254758393\|ref\|ZP_05210420.1\| 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [Bacillus anth... gi\|254756315 - gi\|254756315\|ref\|ZP_05208344.1\| 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [Bacillus anth... gi\|254744610 - gi\|254744610\|ref\|ZP_05202289.1\| 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [Bacillus anth... ISPF_BACAN - 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase OS=Bacillus anthracis GN=ispF PE=3 SV=1 gi\|254733759 - gi\|254733759\|ref\|ZP_05191474.1\| 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [Bacillus anth... gi\|254724227 - gi\|254724227\|ref\|ZP_05186012.1\| 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [Bacillus anth... ISPF_BACCR - 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase OS=Bacillus cereus (strain ATCC 14579 / DSM 31... gi\|254684410 - gi\|254684410\|ref\|ZP_05148270.1\| 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [Bacillus anth... ISPF_BACAA - 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase OS=Bacillus anthracis (strain A0248) GN=ispF P... gi\|229194477, gi... - gi\|229194477\|ref\|ZP_04321280.1\| 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [Bacillus cere... gi\|228600936, gi... - gi\|229182481\|ref\|ZP_04309732.1\| 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [Bacillus cere... gi\|228612478, gi... - gi\|229170938\|ref\|ZP_04298539.1\| 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [Bacillus cere... gi\|228618338, gi... - gi\|229165075\|ref\|ZP_04292870.1\| 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [Bacillus cere... gi\|229153865, gi... - gi\|229153865\|ref\|ZP_04281995.1\| 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [Bacillus cere... gi\|229148496, gi... - gi\|229148496\|ref\|ZP_04276752.1\| 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [Bacillus cere... gi\|74491878, gi\|... - gi\|75760635\|ref\|ZP_00740664.1\| 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [Bacillus thuri... gi\|229142893, gi... - gi\|229142893\|ref\|ZP_04271334.1\| 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [Bacillus cere... gi\|229136933, gi... - gi\|229136933\|ref\|ZP_04265560.1\| 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [Bacillus cere... gi\|228652307, gi... - gi\|229131094\|ref\|ZP_04260006.1\| 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [Bacillus cere... gi\|228657796, gi... - gi\|229125604\|ref\|ZP_04254636.1\| 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [Bacillus cere... ISPF_BACWK - 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase OS=Bacillus weihenstephanensis (strain KBAB4) ... gi\|228663650, gi... - gi\|229119749\|ref\|ZP_04249010.1\| 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [Bacillus cere... gi\|165873147, gi... - gi\|165873147\|ref\|ZP_02217763.1\| 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [Bacillus anthr... gi\|228675622, gi... - gi\|229107773\|ref\|ZP_04237409.1\| 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [Bacillus cere... gi\|167635116, gi... - gi\|167635116\|ref\|ZP_02393433.1\| 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [Bacillus anthr... gi\|229089218, gi... - gi\|229089218\|ref\|ZP_04220499.1\| 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [Bacillus cere... gi\|167641950, gi... - gi\|167641950\|ref\|ZP_02400185.1\| 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [Bacillus anthr... gi\|228721351, gi... - gi\|229053933\|ref\|ZP_04195367.1\| 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [Bacillus cere... gi\|170666487, gi... - gi\|170689574\|ref\|ZP_02880760.1\| 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [Bacillus anthr... gi\|229040992, gi... - gi\|229040992\|ref\|ZP_04189755.1\| 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [Bacillus cere... gi\|228751618, gi... - gi\|229009596\|ref\|ZP_04166822.1\| 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [Bacillus myco... gi\|228976845, gi... - gi\|228976845\|ref\|ZP_04137257.1\| 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [Bacillus thur... gi\|228970275, gi... - gi\|228970275\|ref\|ZP_04130934.1\| 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [Bacillus thur... gi\|228796445, gi... - gi\|228963187\|ref\|ZP_04124356.1\| 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [Bacillus thur... gi\|228803093, gi... - gi\|228956528\|ref\|ZP_04118324.1\| 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [Bacillus thur... gi\|228943893, gi... - gi\|228943893\|ref\|ZP_04106278.1\| 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [Bacillus thur... gi\|228937389, gi... - gi\|228937389\|ref\|ZP_04100035.1\| 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [Bacillus thur... gi\|228931589, gi... - gi\|228931589\|ref\|ZP_04094495.1\| 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [Bacillus thur... ISPF_BACCZ - 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase OS=Bacillus cereus (strain ZK / E33L) GN=ispF ... ISPF_BACAH - 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase OS=Bacillus thuringiensis (strain Al Hakam) GN... gi\|49183120, gi\|... - gi\|49183120\|ref\|YP_026372.1\| 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [Bacillus anthrac... ISPF_BACHK - 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase OS=Bacillus thuringiensis subsp. konkukian (st... gi\|30260277, gi\|... - gi\|30260277\|ref\|NP_842654.1\| 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [Bacillus anthrac... gi\|47525341, gi\|... - gi\|47525341\|ref\|YP_016690.1\| 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [Bacillus anthrac... gi\|47553514, gi\|... - gi\|47569821\|ref\|ZP_00240491.1\| 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [Bacillus cereus... gi\|21398050, gi\|... - gi\|65317547\|ref\|ZP_00390506.1\| COG0245: 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [Bacill...	264.0	[0..2]	[157..3]
ISPF_GEOKA - 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase OS=Geobacillus kaustophilus GN=ispF PE=3 SV=1 ISPF_GEOKA - 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase OS=Geobacillus kaustophilus (strain HTA426) GN...	264.0	[0..2]	[156..3]
gi\|67156386, gi\|... - gi\|67156386\|ref\|ZP_00417979.1\| MECDP-synthase [Azotobacter vinelandii AvOP], ref\|ZP_00091526.1\| COG0... ISPF_AZOVD - 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase OS=Azotobacter vinelandii (strain DJ / ATCC BA...	263.0	[0..1]	[154..1]

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Predicted Domain #1

Region A:
Residues: [1-165]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRIGHGFDVH KFGGEGPLVI GGVRIPYTQG LLAHSDGDVV LHAVTDALLG AAALGDIGKL  60
   61 FPDTDPAFKG ADSRGLLREA WRRINDKGYQ LGNLDVTIIA QAPKMAPHIP QMRVNLAEDL 120
  121 QCHMDDVNVK ATTTEQLGFT GRGEGIACEA VALLVKKETG EIVAW

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	72.522879
Match:	1vh8A
Description:	Crystal structure of a 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity	5.90222038729348	bayes_pls_golite062009
phosphorus-oxygen lyase activity	3.82238498158628	bayes_pls_golite062009
catalytic activity	1.89592759292365	bayes_pls_golite062009
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity	1.55973202658962	bayes_pls_golite062009
lyase activity	1.47817320758946	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: