YRC Public Data Repository - Protein Structure Prediction

Protein:	DHOM_PSEAE
Organism:	Pseudomonas aeruginosa PAO1
Length:	434 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DHOM_PSEAE.

Description	E-value	Query Range	Subject Range
gi\|254242427, gi... - gi\|254242427\|ref\|ZP_04935749.1\| homoserine dehydrogenase [Pseudomonas aeruginosa 2192], gi\|194553412... gi\|126168577, gi... - gi\|254236646\|ref\|ZP_04929969.1\| homoserine dehydrogenase [Pseudomonas aeruginosa C3719], gi\|19454763... gi\|115586955, gi... - gi\|116051734\|ref\|YP_789427.1\| homoserine dehydrogenase [Pseudomonas aeruginosa UCBPP-PA14], gi\|11558...	0.0	[1..434]	[1..434]
gi\|82702680, gi\|... - gi\|82702680\|ref\|YP_412246.1\| homoserine dehydrogenase [Nitrosospira multiformis ATCC 25196], gi\|8241...	0.0	[1..433]	[14..449]
gi\|113868242, gi... - gi\|113868242\|ref\|YP_726731.1\| homoserine dehydrogenase [Ralstonia eutropha H16], gi\|113527018\|emb\|CA...	0.0	[1..434]	[1..436]
tr\|Q886U6\|Q886U6... - Homoserine dehydrogenase OS=Pseudomonas syringae pv. tomato (strain DC3000) GN=hom PE=3 SV=1 gi\|28868687, gi\|... - gi\|28868687\|ref\|NP_791306.1\| homoserine dehydrogenase [Pseudomonas syringae pv. tomato str. DC3000],... gi\|213926060, gi... - gi\|213969062\|ref\|ZP_03397201.1\| homoserine dehydrogenase [Pseudomonas syringae pv. tomato T1], gi\|21...	0.0	[1..434]	[1..434]
gi\|46121076, gi\|... - gi\|91775401\|ref\|YP_545157.1\| homoserine dehydrogenase [Methylobacillus flagellatus KT], gi\|91775257\|...	0.0	[1..434]	[1..436]
gi\|66044538, gi\|... - gi\|66044538\|ref\|YP_234379.1\| homoserine dehydrogenase [Pseudomonas syringae pv. syringae B728a], gi\|...	0.0	[2..434]	[31..463]
gi\|71735728, gi\|... - gi\|71735728\|ref\|YP_273618.1\| homoserine dehydrogenase [Pseudomonas syringae pv. phaseolicola 1448A],...	0.0	[1..434]	[1..434]
gi\|94310904, gi\|... - gi\|94310904\|ref\|YP_584114.1\| homoserine dehydrogenase [Ralstonia metallidurans CH34], gi\|93354756\|gb...	0.0	[1..434]	[1..436]
gi\|53761449, gi\|... - gi\|73541681\|ref\|YP_296201.1\| homoserine dehydrogenase [Ralstonia eutropha JMP134], gi\|72119094\|gb\|AA...	0.0	[1..434]	[1..436]
gi\|24982941, gi\|... - gi\|26988203\|ref\|NP_743628.1\| homoserine dehydrogenase [Pseudomonas putida KT2440], gi\|24982941\|gb\|AA... gi\|82714907, gi\|... - gi\|82738016\|ref\|ZP_00900857.1\| homoserine dehydrogenase [Pseudomonas putida F1], gi\|82714907\|gb\|EAP4... tr\|E4RGM0\|E4RGM0... - Homoserine dehydrogenase OS=Pseudomonas putida (strain BIRD-1) GN=hom PE=3 SV=1 tr\|I7BWZ3\|I7BWZ3... - Homoserine dehydrogenase OS=Pseudomonas putida (strain DOT-T1E) GN=hom PE=3 SV=1	0.0	[1..434]	[1..434]

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Predicted Domain #1

Region A:
Residues: [1-325]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKPVKVGICG LGTVGGGTFN VLERNAEEIA RRAGRGIEVA QIAARRPNPK CDTGATPITA  60
   61 DIFDVACNPE IDVVVELIGG YTLAHELVLK AIENGKHVVT ANKALIAVHG NEIFAKAREK 120
  121 GVIVAFEAAV AGGIPVIKAI REGLSANRIN WLAGIINGTG NFILSEMREK GRTFPDVLAE 180
  181 AQALGYAEAD PTFDVEGIDA AHKLTILASI AFGIPLQFDK AYTEGISKLT SADVNYADAL 240
  241 GYRIKHLGVA RRTESGFELR VHPTLIPSDR LIANVNGVMN AVMVNGDAVG STLYYGAGAG 300
  301 MEPTASSVVA DLVDVVRAMT SDPEN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	30.045757
Match:	1q7gA
Description:	Homoserine Dehydrogenase in complex with suicide inhibitor complex NAD-5-hydroxy-4-Oxonorvaline
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
aspartate-semialdehyde dehydrogenase activity	3.92511214237139	bayes_pls_golite062009
catalytic activity	2.91887313269429	bayes_pls_golite062009
oxidoreductase activity	2.86254373278283	bayes_pls_golite062009
dihydrodipicolinate reductase activity	1.71989205356835	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	1.19591951564949	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	1.07932840802619	bayes_pls_golite062009
ketol-acid reductoisomerase activity	0.57325534211306	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	0.23458869447046	bayes_pls_golite062009
N-acetyl-gamma-glutamyl-phosphate reductase activity	0.22364954992375	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	0.22262673350502	bayes_pls_golite062009
glyceraldehyde-3-phosphate dehydrogenase activity	0.0876163188309598	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [326-434]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RVPHLAFQPD ALSDHPILPI EACESAYYLR IQAKDHPGVL AQVATILSER GINIESIMQK  60
   61 EAEEQDGLVP MILVTHRVIE QRINDAIAAL EALEGVSGPV VRIRVEQLN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	4.045757
Match:	2fgcA
Description:	Crystal structure of Acetolactate synthase- small subunit from Thermotoga maritima
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
acetolactate synthase activity	5.6098771388969	bayes_pls_golite062009
transferase activity, transferring aldehyde or ketonic groups	4.76464602837385	bayes_pls_golite062009
catalytic activity	1.01569611874813	bayes_pls_golite062009
transferase activity	0.07375530569672	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: