YRC Public Data Repository - Protein Structure Prediction

Protein:	ISPE_PSEAE
Organism:	Pseudomonas aeruginosa PAO1
Length:	282 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ISPE_PSEAE.

Description	E-value	Query Range	Subject Range
ISPE_PSEA8 - 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase OS=Pseudomonas aeruginosa (strain LESB58) GN=ispE ... gi\|126197817, gi... - gi\|84323295\|ref\|ZP_00971368.1\| COG1947: 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate syntha...	3.0E-73	[1..282]	[1..282]
ISPE_PSEAB - 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase OS=Pseudomonas aeruginosa (strain UCBPP-PA14) GN=i...	5.0E-73	[1..282]	[1..282]
gi\|84317262, gi\|... - gi\|84317262\|ref\|ZP_00965713.1\| COG1947: 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate syntha...	1.0E-72	[1..282]	[1..282]
gi\|107099664 - gi\|107099664\|ref\|ZP_01363582.1\| hypothetical protein PaerPA_01000682 [Pseudomonas aeruginosa PACS2]	2.0E-72	[1..282]	[1..282]
ISPE_PSEA7 - 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase OS=Pseudomonas aeruginosa (strain PA7) GN=ispE PE=...	2.0E-72	[1..282]	[1..282]
gi\|49083369 - gi\|49083369\|gb\|AAT51014.1\| PA4669 [synthetic construct]	3.0E-72	[1..282]	[1..282]
ISPE_PSEF5 - 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase OS=Pseudomonas fluorescens (strain Pf-5 / ATCC BAA...	2.0E-69	[1..282]	[1..283]
ISPE_MANSM - 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase OS=Mannheimia succiniciproducens (strain MBEL55E) ...	9.0E-69	[7..281]	[22..296]
ISPE_PSEU2 - 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase OS=Pseudomonas syringae pv. syringae (strain B728a...	8.0E-68	[5..281]	[6..282]
ISPE_PSEPF - 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase OS=Pseudomonas fluorescens (strain Pf0-1) GN=ispE ...	8.0E-68	[4..282]	[5..283]

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Predicted Domain #1

Region A:
Residues: [1-282]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVRLSLPAP AKLNLFLHIL GRRDDGYHEL QTLFQFLDHG DELHFEARQD GQVRLHTEIA  60
   61 GVPHDSNLIV RAARGLQEAS GSPQGVDIWL DKRLPMGGGI GGGSSDAATT LLALNHLWQL 120
  121 GWDEDRIAAL GLRLGADVPV FTRGRAAFAE GVGEKLTPVD IPEPWYLVVV PQVLVSTAEI 180
  181 FSDPLLTRDS PAIKVRTVLE GDSRNDCQPV VERRYPEVRN ALILLNKFVS ARLTGTGGCV 240
  241 FGSFPNKAEA DKVSALLPDH LQRFVAKGSN ISMLHRKLET LV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	67.39794
Match:	1oj4A
Description:	Ternary complex of 4-diphosphocytidyl-2C-methyl-D-erythritol kinase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity	1.9881460462076	bayes_pls_golite062009
catalytic activity	1.20658247466773	bayes_pls_golite062009
diphosphomevalonate decarboxylase activity	1.0502744466494	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: