YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|7473980
Organism:	Deinococcus radiodurans
Length:	387 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|7473980.

Description	E-value	Query Range	Subject Range
gi\|13096425 - gi\|13096425\|pdb\|1HW4\|A Chain A, Structure Of Thymidylate Synthase Suggests Advantages Of Chemotherap...	0.0	[80..387]	[9..355]
gi\|11256673 - pir\|\|G81050 thymidylate synthase NMB1709 [imported] - Neisseria meningitidis (strain MC58 serogroup ... TYSY_NEIMB - Thymidylate synthase OS=Neisseria meningitidis serogroup B (strain MC58) GN=thyA PE=3 SV=1 TYSY_NEIMB - Thymidylate synthase OS=Neisseria meningitidis serogroup B GN=thyA PE=3 SV=1	0.0	[124..387]	[1..264]
gi\|240017051 - gi\|240017051\|ref\|ZP_04723591.1\| thymidylate synthase [Neisseria gonorrhoeae FA6140] gi\|240014606 - gi\|240014606\|ref\|ZP_04721519.1\| thymidylate synthase [Neisseria gonorrhoeae DGI18] gi\|239999430 - gi\|239999430\|ref\|ZP_04719354.1\| thymidylate synthase [Neisseria gonorrhoeae 35/02] gi\|240118411 - gi\|240118411\|ref\|ZP_04732473.1\| thymidylate synthase [Neisseria gonorrhoeae PID1] gi\|240116127 - gi\|240116127\|ref\|ZP_04730189.1\| thymidylate synthase [Neisseria gonorrhoeae PID18] gi\|240113520 - gi\|240113520\|ref\|ZP_04728010.1\| thymidylate synthase [Neisseria gonorrhoeae MS11] gi\|240081310 - gi\|240081310\|ref\|ZP_04725853.1\| thymidylate synthase [Neisseria gonorrhoeae FA19] TYSY_NEIG1 - Thymidylate synthase OS=Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090) GN=thyA PE=3 SV=1 gi\|240128633 - gi\|240128633\|ref\|ZP_04741294.1\| thymidylate synthase [Neisseria gonorrhoeae SK-93-1035] gi\|240126156 - gi\|240126156\|ref\|ZP_04739042.1\| thymidylate synthase [Neisseria gonorrhoeae SK-92-679] gi\|240123956 - gi\|240123956\|ref\|ZP_04736912.1\| thymidylate synthase [Neisseria gonorrhoeae PID332] gi\|240121128 - gi\|240121128\|ref\|ZP_04734090.1\| thymidylate synthase [Neisseria gonorrhoeae PID24-1] gi\|226513187, gi... - gi\|254494147\|ref\|ZP_05107318.1\| thymidylate synthase [Neisseria gonorrhoeae 1291], gi\|226513187\|gb\|E...	0.0	[124..387]	[1..264]
gi\|11256672 - pir\|\|A81825 thymidylate synthase (EC 2.1.1.45) NMA1963 [imported] - Neisseria meningitidis (strain Z... TYSY_NEIMA - Thymidylate synthase OS=Neisseria meningitidis serogroup A GN=thyA PE=3 SV=1 TYSY_NEIMA - Thymidylate synthase OS=Neisseria meningitidis serogroup A / serotype 4A (strain Z2491) GN=thyA PE=3...	0.0	[124..387]	[1..264]
TYSY_METFK - Thymidylate synthase OS=Methylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875) GN=thyA1 PE=...	0.0	[124..387]	[1..264]
TYSY_CYTH3 - Thymidylate synthase OS=Cytophaga hutchinsonii (strain ATCC 33406 / NCIMB 9469) GN=thyA PE=3 SV=1 gi\|48855118 - gi\|48855118\|ref\|ZP_00309278.1\| COG0207: Thymidylate synthase [Cytophaga hutchinsonii]	0.0	[124..387]	[1..264]
gi\|253323363, gi... - gi\|254289514\|ref\|YP_003055262.1\| thymidylate synthase [Escherichia coli BL21(DE3)], gi\|253978821\|gb\|... gi\|242378375, gi... - gi\|251786102\|ref\|YP_003000406.1\| hypothetical protein B21_02636 [Escherichia coli BL21], gi\|24237837... gi\|253974656, gi... - gi\|254162755\|ref\|YP_003045863.1\| thymidylate synthase [Escherichia coli B str. REL606], gi\|253974656... gi\|83584784, gi\|... - gi\|83584784\|ref\|ZP_00923446.1\| COG0207: Thymidylate synthase [Escherichia coli 101-1], gi\|194439864\|...	0.0	[124..387]	[1..264]
TYSY_BACHD - Thymidylate synthase OS=Bacillus halodurans GN=thyA PE=3 SV=1 TYSY_BACHD - Thymidylate synthase OS=Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 ...	0.0	[124..387]	[1..264]
gi\|170125070, gi... - gi\|170765924\|ref\|ZP_02900735.1\| thymidylate synthase [Escherichia albertii TW07627], gi\|170125070\|gb... gi\|195936429 - gi\|195936429\|ref\|ZP_03081811.1\| thymidylate synthase [Escherichia coli O157:H7 str. EC4024] gi\|208726311, gi... - gi\|208806510\|ref\|ZP_03248847.1\| thymidylate synthase [Escherichia coli O157:H7 str. EC4206], gi\|2087... gi\|208735423, gi... - gi\|208814146\|ref\|ZP_03255475.1\| thymidylate synthase [Escherichia coli O157:H7 str. EC4045], gi\|2087... gi\|208818648, gi... - gi\|208818648\|ref\|ZP_03258968.1\| thymidylate synthase [Escherichia coli O157:H7 str. EC4042], gi\|2087... gi\|209400848, gi... - gi\|209400848\|ref\|YP_002272290.1\| thymidylate synthase [Escherichia coli O157:H7 str. EC4115], gi\|209... gi\|209920275, gi... - gi\|209920275\|ref\|YP_002294359.1\| thymidylate synthase [Escherichia coli SE11], gi\|209913534\|dbj\|BAG7... TYSY_ECO27 - Thymidylate synthase OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=thyA PE=3 SV=1 gi\|168764657, gi... - gi\|189365398\|gb\|EDU83814.1\| thymidylate synthase [Escherichia coli O157:H7 str. EC4501], gi\|16876465... gi\|168766799, gi... - gi\|189363818\|gb\|EDU82237.1\| thymidylate synthase [Escherichia coli O157:H7 str. EC4486], gi\|16876679... gi\|187767149, gi... - gi\|187767149\|gb\|EDU30993.1\| thymidylate synthase [Escherichia coli O157:H7 str. EC4196], gi\|16877765... gi\|189003343, gi... - gi\|189003343\|gb\|EDU72329.1\| thymidylate synthase [Escherichia coli O157:H7 str. EC4076], gi\|16877882... gi\|168788090, gi... - gi\|189372183\|gb\|EDU90599.1\| thymidylate synthase [Escherichia coli O157:H7 str. EC869], gi\|168788090... gi\|168801690, gi... - gi\|189376199\|gb\|EDU94615.1\| thymidylate synthase [Escherichia coli O157:H7 str. EC508], gi\|168801690... gi\|169890230, gi... - gi\|170082395\|ref\|YP_001731715.1\| thymidylate synthetase [Escherichia coli str. K-12 substr. DH10B], ... gi\|170521980, gi... - gi\|170684262\|ref\|YP_001744995.1\| thymidylate synthase [Escherichia coli SMS-3-5], gi\|170521980\|gb\|AC... gi\|217327216, gi... - gi\|217327216\|ref\|ZP_03443299.1\| thymidylate synthase [Escherichia coli O157:H7 str. TW14588], gi\|217... TYSY_ECOLI - Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) - Escherichia coli TYSY_ECO8A - Thymidylate synthase OS=Escherichia coli O8 (strain IAI1) GN=thyA PE=3 SV=1 TYSY_ECO45 - Thymidylate synthase OS=Escherichia coli O45:K1 (strain S88 / ExPEC) GN=thyA PE=3 SV=1 TYSY_ECO81 - Thymidylate synthase OS=Escherichia coli O81 (strain ED1a) GN=thyA PE=3 SV=1 TYSY_ECO55 - Thymidylate synthase OS=Escherichia coli (strain 55989 / EAEC) GN=thyA PE=3 SV=1 TYSY_ECO7I - Thymidylate synthase OS=Escherichia coli O7:K1 (strain IAI39 / ExPEC) GN=thyA PE=3 SV=1 TYSY_ECOLU - Thymidylate synthase OS=Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC) GN=thyA PE=3 SV=1 TYSY_ECOUT - Thymidylate synthase OS=Escherichia coli (strain UTI89 / UPEC) GN=thyA PE=3 SV=1 gi\|13363156, gi\|... - gi\|15832938\|ref\|NP_311711.1\| thymidylate synthase [Escherichia coli O157:H7 str. Sakai], gi\|13363156... gi\|85675643, gi\|... - gi\|89109610\|ref\|AP_003390.1\| thymidylate synthetase [Escherichia coli str. K-12 substr. W3110], gi\|8... gi\|188490192, gi... - gi\|75511967\|ref\|ZP_00734570.1\| COG0207: Thymidylate synthase [Escherichia coli 53638], gi\|188494993\|... TYSY_SHISS - Thymidylate synthase OS=Shigella sonnei (strain Ss046) GN=thyA PE=3 SV=1 sp\|B7UHP4\|TYSY_ECO27 - Thymidylate synthase OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=thyA PE=3 SV=1 TYSY_ECOL5 - Thymidylate synthase OS=Escherichia coli O6:K15:H31 (strain 536 / UPEC) GN=thyA PE=3 SV=1 gi\|188014880, gi... - gi\|188014880\|gb\|EDU53002.1\| thymidylate synthase [Escherichia coli O157:H7 str. EC4113], gi\|16875104... gi\|189354949, gi... - gi\|189354949\|gb\|EDU73368.1\| thymidylate synthase [Escherichia coli O157:H7 str. EC4401], gi\|16875821... TYSY_ECO24 - Thymidylate synthase OS=Escherichia coli O139:H28 (strain E24377A / ETEC) GN=thyA PE=3 SV=1 gi\|194415713, gi... - gi\|75212540\|ref\|ZP_00712564.1\| COG0207: Thymidylate synthase [Escherichia coli B171], gi\|194426405\|r... gi\|194417391, gi... - gi\|83569179\|ref\|ZP_00920637.1\| COG0207: Thymidylate synthase [Shigella dysenteriae 1012], gi\|1944343... gi\|191171260, gi... - gi\|75241764\|ref\|ZP_00725583.1\| COG0207: Thymidylate synthase [Escherichia coli F11], gi\|191171260\|re... TYSY_ECOK1 - Thymidylate synthase OS=Escherichia coli O1:K1 / APEC GN=thyA PE=3 SV=1 gi\|75256821, gi\|... - gi\|75256821\|ref\|ZP_00728415.1\| COG0207: Thymidylate synthase [Escherichia coli E22], gi\|193065099\|re... gi\|193071410, gi... - gi\|75215031\|ref\|ZP_00713491.1\| COG0207: Thymidylate synthase [Escherichia coli E110019], gi\|19307141... gi\|191168602, gi... - gi\|75228183\|ref\|ZP_00714845.1\| COG0207: Thymidylate synthase [Escherichia coli B7A], gi\|191168602\|re... gi\|15803346, gi\|... - gi\|15803346\|ref\|NP_289379.1\| thymidylate synthase [Escherichia coli O157:H7 EDL933], gi\|12517312\|gb\|... EG11002 - thymidylate synthetase / Thymidylate synthase; aminopterin, trimethoprim resistance; homodimer TYSY_ECOL6 - Thymidylate synthase OS=Escherichia coli O6 GN=thyA PE=3 SV=1 gi\|227888391, gi... - gi\|227888391\|ref\|ZP_04006196.1\| thymidylate synthase [Escherichia coli 83972], gi\|227834660\|gb\|EEJ45... gi\|237706513, gi... - gi\|237706513\|ref\|ZP_04536994.1\| thymidylate synthetase [Escherichia sp. 3_2_53FAA], gi\|226899553\|gb\|... TYSY_ECOBW - Thymidylate synthase OS=Escherichia coli (strain K12 / MC4100 / BW2952) GN=thyA PE=3 SV=1 gi\|254037878, gi... - gi\|254037878\|ref\|ZP_04871936.1\| thymidylate synthetase [Escherichia sp. 1_1_43], gi\|226839502\|gb\|EEH... gi\|254594165, gi... - gi\|254794765\|ref\|YP_003079602.1\| thymidylate synthetase [Escherichia coli O157:H7 str. TW14359], gi\|... TYSY_ECOL6 - Thymidylate synthase OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) GN=thyA PE=3 SV=... TYSY_ECO57 - Thymidylate synthase OS=Escherichia coli O157:H7 GN=thyA PE=1 SV=1 EG11002 - thymidylate synthetase / Thymidylate synthase; aminopterin, trimethoprim resistance; homodimer	0.0	[124..387]	[1..264]
gi\|157830328, gi... - gi\|3891614\|pdb\|1AXW\|B Chain B, E. Coli Thymidylate Synthase In Complex With Methotrexate (Mtx) And 2...	0.0	[124..387]	[2..265]

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Predicted Domain #1

Region A:
Residues: [1-120]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRYFTPPPGA VYCPHEPRTL PAGFARAPAP LPVPLRHGRA DRAARRPADG RPRRARHPTA  60
   61 QRLCTRHVCR HRGHQHAGGA LSRPERQNLR AGARCYRHVV CRKFCAAART GLRRLGRHAG 120
  121

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [121-387]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AQAVKQYLDF LRHIRDHGTD KMDRTGTGTR SVFGYQMRFD LSEGFPLVTT KRVHLKSIIY  60
   61 ELLWFLRGDS NVRWLQEHGV TIWDEWAREG GELGPVYGVQ WRSWPDYGGG QIDQISQVIE 120
  121 QIKTNPDSRR LIVSAWNVAQ IDEMALPPCH LLFQFYVADG KLSCQLYQRS ADSFLGVPFN 180
  181 IASYALLTMM VAQVCGLEPG EFIWTGGDCH IYSNHMEQVE RQLKREPRPL PKMRLNPAVK 240
  241 DMFAFQYEDF TLEGYDPHPG IKAEVAV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	130.0
Match:	1f4bA
Description:	Thymidylate synthase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
thymidylate synthase activity	6.6988475347328	bayes_pls_golite062009
5,10-methylenetetrahydrofolate-dependent methyltransferase activity	6.29181090719132	bayes_pls_golite062009
binding	1.89072001556053	bayes_pls_golite062009
catalytic activity	1.73427871128495	bayes_pls_golite062009
transferase activity	1.72626940963556	bayes_pls_golite062009
methyltransferase activity	0.927096828883487	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	0.91282507161672	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: